Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation

scientific article published on 20 January 2012

Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.326850
P932PMC publication ID3318758
P698PubMed publication ID22267732

P2093author name stringReuben P Siraganian
Juan Zhang
Rodrigo Orlandini de Castro
Emilia Alina Barbu
Jacqueline R Groves
P2860cites workNck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytesQ24307359
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell developmentQ24314695
A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in plateletsQ24336773
Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing proteinQ24540267
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)Q24595848
New developments in mast cell biologyQ24634390
The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin networkQ24682994
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70Q27644831
A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR SignalingQ27646954
SH2 domains recognize specific phosphopeptide sequencesQ27860748
The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptorsQ28137592
Mast cell signal transduction from the high-affinity IgE receptorQ28186015
Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-AblQ28235300
SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cellsQ28301306
Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell functionQ28513137
Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyQ28573020
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2Q28587191
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase SykQ28619124
Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinasesQ30157759
The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.Q30159822
Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinasesQ30164059
TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitinQ30164133
The Nck family of adapter proteins: regulators of actin cytoskeletonQ30165392
Decoding protein-protein interactions through combinatorial chemistry: sequence specificity of SHP-1, SHP-2, and SHIP SH2 domainsQ33226743
TOM1L1 is a Lyn substrate involved in FcepsilonRI signaling in mast cellsQ33304751
Small interfering RNA screen for phosphatases involved in IgE-mediated mast cell degranulationQ33581708
Structures of the phosphorylated and VO(3)-bound 2H-phosphatase domain of Sts-2.Q33644549
Determination of the Substrate Specificity of Protein-tyrosine Phosphatase TULA-2 and Identification of Syk as a TULA-2 SubstrateQ33645197
SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cellsQ33853163
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cellsQ33855085
Calcium signaling in immune cells.Q33878792
Tyrosines in the carboxyl terminus regulate Syk kinase activity and functionQ34074500
Competition between solution and cell surface receptors for ligand. Dissociation of hapten bound to surface antibody in the presence of solution antibodyQ34125217
Mast cell signaling: the role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participantsQ34388351
Adapters in the organization of mast cell signalingQ34476441
T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosisQ34665121
TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.Q34713979
Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cellsQ34784234
Protein tyrosine kinase Syk in mast cell signalingQ34825330
Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathwaysQ34963266
Regulation and function of syk tyrosine kinase in mast cell signaling and beyondQ35101718
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulationQ36310121
Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membraneQ36320717
Integrated signalling pathways for mast-cell activationQ36392833
Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptidesQ36557865
Quantitative time-resolved phosphoproteomic analysis of mast cell signalingQ37307359
The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathwaysQ37376318
Cooperation of adapter molecules in proximal signaling cascades during allergic inflammationQ37631696
Autoinhibition and adapter function of Syk.Q37631725
New insights into the structural mechanisms of the COPII coatQ37673324
Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76Q37746483
TULA proteins regulate activity of the protein tyrosine kinase Syk.Q40026226
Mutations in the activation loop tyrosines of protein tyrosine kinase Syk abrogate intracellular signaling but not kinase activityQ41001738
The role of SHIP in mast cell degranulation and IgE-induced mast cell survivalQ43991319
T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.Q47982347
IgE-induced histamine release from rat basophilic leukemia cell lines: isolation of releasing and nonreleasing clonesQ52834043
Selective impairment of Fc RI-mediated allergic reaction in Gads-deficient miceQ57949079
The negative signaling molecule SH2 domain-containing inositol-polyphosphate 5-phosphatase (SHIP) binds to the tyrosine-phosphorylated beta subunit of the high affinity IgE receptorQ73343323
SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa B activityQ77995921
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectmast cellQ191989
phosphorylationQ242736
P1104number of pages11
P304page(s)8194-8204
P577publication date2012-01-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleOnce phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation
P478volume287

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Q28854385TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk
Q28586059TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function
Q38634867The extended human PTPome: a growing tyrosine phosphatase family
Q90623254The lectin ArtinM activates RBL-2H3 mast cells without inducing degranulation
Q48007320Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation

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