Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

scientific article

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.07836
P932PMC publication ID4541496
P698PubMed publication ID26196144

P50authorMichael J SteinbaughQ57338703
P2093author name stringJonathan M Dreyfuss
Prashant Raghavan
John M Hourihan
Lorenza E Moronetti Mazzeo
T Keith Blackwell
Sri Devi Narasimhan
Reza Esmaillie
Stacey Robida-Stubbs
Theresa N Operaña
P2860cites workTissue-specific activities of C. elegans DAF-16 in the regulation of lifespanQ46366442
RPN-6 determines C. elegans longevity under proteotoxic stress conditionsQ46942610
skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryoQ47068766
Reporter transgenes for study of oxidant stress in Caenorhabditis elegansQ74340127
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substratesQ81453964
Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat dietQ84966488
Cell biology. Lysosomal lipid lengthens life spanQ86443165
The lifespan of Korean eunuchsQ87388020
The impact of bone marrow adipocytes on osteoblast and osteoclast differentiationQ87461688
Bioconductor: open software development for computational biology and bioinformaticsQ21194861
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of constructionQ24292709
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasisQ24294691
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alphaQ24319974
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologuesQ24532085
The genetics of Caenorhabditis elegansQ24533408
TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotesQ24538709
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans agingQ24643933
MATCH: A tool for searching transcription factor binding sites in DNA sequencesQ24677633
Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegansQ24791911
Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegansQ27311639
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegansQ27322410
The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegansQ27324113
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activityQ27339698
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegansQ27349187
DAVID: Database for Annotation, Visualization, and Integrated DiscoveryQ27499374
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegansQ27860971
Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasiaQ28237402
Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97Q28243388
Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymesQ28245245
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxOQ28266047
Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cellsQ28279454
A steroid receptor-microRNA switch regulates life span in response to signals from the gonadQ28281375
Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in miceQ28291312
Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loopQ28295179
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibitionQ28306282
Stress-activated cap'n'collar transcription factors in aging and human diseaseQ28384783
A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methodsQ28475523
The genetics of ageingQ29547430
Count-based differential expression analysis of RNA sequencing data using R and BioconductorQ29577114
JASPAR: an open-access database for eukaryotic transcription factor binding profilesQ29614419
STAR: ultrafast universal RNA-seq alignerQ29615052
Two neurons mediate diet-restriction-induced longevity in C. elegansQ29617239
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegansQ29618073
Protein degradation and protection against misfolded or damaged proteinsQ29618400
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegansQ29619580
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signalingQ29619762
Signals from the reproductive system regulate the lifespan of C. elegansQ29620314
Obesity-driven disruption of haematopoiesis and the bone marrow niche.Q30367783
Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevityQ30625412
Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegansQ30840424
BioMart and Bioconductor: a powerful link between biological databases and microarray data analysisQ30998448
Lifespan regulation by evolutionarily conserved genes essential for viabilityQ33281293
Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegansQ33471424
ChIPpeakAnno: a Bioconductor package to annotate ChIP-seq and ChIP-chip dataQ33575507
The Caenorhabditis elegans germ line regulates distinct signaling pathways to control lifespan and innate immunityQ33581925
Nrf2 signaling, a mechanism for cellular stress resistance in long-lived miceQ33614059
voom: Precision weights unlock linear model analysis tools for RNA-seq read countsQ33741687
C. elegans major fats are stored in vesicles distinct from lysosome-related organellesQ34066502
Fatty acid composition of human adipose tissue from two anatomical sites in a biracial communityQ34224652
Basic Caenorhabditis elegans methods: synchronization and observationQ34308202
The Subread aligner: fast, accurate and scalable read mapping by seed-and-voteQ34337291
featureCounts: an efficient general purpose program for assigning sequence reads to genomic featuresQ34384848
Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegansQ34456343
Diverse transcription factor binding features revealed by genome-wide ChIP-seq in C. elegansQ34625961
No place like home: anatomy and function of the stem cell nicheQ34655535
Software for computing and annotating genomic rangesQ34945230
OrthoList: a compendium of C. elegans genes with human orthologsQ35007364
20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegansQ35039312
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signalsQ35125807
Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRtQ35174434
mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevityQ35209468
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegansQ35316092
Human fatty liver disease: old questions and new insightsQ35588477
Sex and death: what is the connection?Q36056296
Proteomic study and marker protein identification of Caenorhabditis elegans lipid dropletsQ36144142
Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespanQ36175894
Reproduction, fat metabolism, and life span: what is the connection?Q36596610
Techniques for analysis, sorting, and dispensing of C. elegans on the COPAS flow-sorting systemQ36599667
Drosophila germ-line modulation of insulin signaling and lifespanQ36609160
Fat chance for longevityQ36660183
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagyQ36660198
Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complexQ36666210
Regulation of longevity by the reproductive systemQ36673555
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signalQ36835127
Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte.Q36956321
Mitochondrial hormesis links low-dose arsenite exposure to lifespan extensionQ37005002
Synaptic functionQ37020445
Germline proliferation and its controlQ37020487
Sarcomere assembly in C. elegans muscleQ37020737
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availabilityQ37045468
Mitochondrial SKN-1/Nrf mediates a conserved starvation responseQ37174370
The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegansQ37192059
METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegansQ37351802
Fat metabolism links germline stem cells and longevity in C. elegansQ37383382
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1.Q37387918
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.Q37419745
The mystery of C. elegans aging: an emerging role for fat. Distant parallels between C. elegans aging and metabolic syndrome?Q37988793
The Nrf2 regulatory network provides an interface between redox and intermediary metabolismQ38197467
Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegansQ39001279
Synchronous Growth and Aging of Caenorhabditis elegans in the Presence of FluorodeoxyuridineQ39872065
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress responseQ39896060
Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.Q41823360
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress responseQ41916654
SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivationQ42069628
Regulation of life-span by germ-line stem cells in Caenorhabditis elegansQ45270751
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.Q46035393
P4510describes a project that useslimmaQ112236343
P407language of work or nameEnglishQ1860
P577publication date2015-07-21
P1433published ineLifeQ2000008
P1476titleLipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
P478volume4

Reverse relations

cites work (P2860)
Q52688918A Damage Sensor Associated with the Cuticle Coordinates Three Core Environmental Stress Responses in Caenorhabditis elegans.
Q46379821A Genetic Analysis of the Caenorhabditis elegans Detoxification Response
Q28817531A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans
Q39449072Age-associated vulval integrity is an important marker of nematode healthspan
Q38725828An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
Q48190542BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1.
Q94524550Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies
Q41549003Cell cycle controls stress response and longevity in C. elegans
Q27309247DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans
Q64261547Dietary restriction and gonadal signaling differentially regulate post-development quality control functions in Caenorhabditis elegans
Q41352574Dietary-Induced Signals That Activate the Gonadal Longevity Pathway during Development Regulate a Proteostasis Switch in Caenorhabditis elegans Adulthood
Q36203731Ectopic fat deposition contributes to age-associated pathology in Caenorhabditis elegans
Q90658172Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans
Q64101007Epigenetic regulator G9a provides glucose as a sweet key to stress resistance
Q41663189Fat-containing cells are eliminated during Dictyostelium development
Q51803542Good Ol' Fat: Links between Lipid Signaling and Longevity.
Q90038501Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria
Q36279961Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7.
Q38862292Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans
Q36648689Isolation of a Hypomorphic skn-1 Allele That Does Not Require a Balancer for Maintenance
Q37234257Linking Gene Expression in the Intestine to Production of Gametes Through the Phosphate Transporter PITR-1 in Caenorhabditis elegans
Q57479283Linking Lipid Metabolism to Chromatin Regulation in Aging
Q47696246Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
Q92593044MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis
Q47953887MGL-1 on AIY neurons translates starvation to reproductive plasticity via neuropeptide signaling in Caenorhabditis elegans
Q31160447Metabolomic signature associated with reproduction-regulated aging in Caenorhabditis elegans
Q64261524Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans
Q50420708NHR-49/HNF4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting.
Q36722812Nuclear hormone receptors as mediators of metabolic adaptability following reproductive perturbations
Q36394383Omega-3 and -6 fatty acids allocate somatic and germline lipids to ensure fitness during nutrient and oxidative stress in Caenorhabditis elegans
Q49994822Oxidative Stress Assays (arsenite and tBHP) in Caenorhabditis elegans.
Q38745971PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
Q58601608PRY-1/Axin signaling regulates lipid metabolism in Caenorhabditis elegans
Q41740375Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
Q39517795Protein Kinase A Subunit Balance Regulates Lipid Metabolism in Caenorhabditis elegans and Mammalian Adipocytes
Q90015434Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
Q64058173RNA interference may result in unexpected phenotypes in Caenorhabditis elegans
Q90701950Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection
Q26751266Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
Q36931039Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans
Q90243928SKN-1 Is a Negative Regulator of DAF-16 and Somatic Stress Resistance in Caenorhabditis elegans
Q39988144SKN-1-independent transcriptional activation of glutathione S-transferase 4 (GST-4) by EGF signaling
Q36733239SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans
Q39235911Shaping proteostasis at the cellular, tissue, and organismal level
Q104286529Stressful development: Integrating endoderm development, stress, and longevity
Q42626854Stressing about misplaced fat is a key to longevity
Q90597750TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging
Q36875656TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans
Q64886413The Effects of Age and Reproduction on the Lipidome of Caenorhabditis elegans.
Q47099823The MXL-3/SBP-1 Axis Is Responsible for Glucose-Dependent Fat Accumulation in C. elegans.
Q36173010The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK
Q59925072The multifaceted role of Nrf2 in mitochondrial function
Q33804604The protein kinase MBK-1 contributes to lifespan extension in daf-2 mutant and germline-deficient Caenorhabditis elegans
Q41628826The ω-3 fatty acid α-linolenic acid extends Caenorhabditis elegans lifespan via NHR-49/PPARα and oxidation to oxylipins
Q30491525Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
Q33615396Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases
Q26768611Using Caenorhabditis elegans to Uncover Conserved Functions of Omega-3 and Omega-6 Fatty Acids
Q90264252Vitellogenins - Yolk Gene Function and Regulation in Caenorhabditis elegans

Search more.