Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens

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Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1009764769
P356DOI10.1038/NCB2072
P932PMC publication ID3428211
P698PubMed publication ID20543839
P5875ResearchGate publication ID44669127

P50authorNicholas HamiltonQ54900925
Michael SmutnyQ59702553
Robert G. PartonQ30347571
Alpha YapQ37377160
Robert S. AdelsteinQ49165615
P2093author name stringCharles Ferguson
Mary Anne Conti
Eva M Kovacs
Hayley L Cox
Joanne M Leerberg
P2860cites workDisease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-CQ24300550
Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic functionQ24306891
Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contactsQ24319256
Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epitheliumQ78319031
The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctionsQ81538029
The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctnQ24683225
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
Nonmuscle myosin II moves in new directionsQ28261837
Non-muscle myosin II takes centre stage in cell adhesion and migrationQ28262326
Mechanism of blebbistatin inhibition of myosin IIQ28267628
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathwaysQ28511099
Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in miceQ28511656
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interferenceQ29615920
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent mannerQ29616027
Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epitheliaQ30437856
Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganizationQ30443460
Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contactsQ30476214
Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contactsQ30476860
Enhanced EGFP-chromophore-assisted laser inactivation using deficient cells rescued with functional EGFP-fusion proteinsQ30479466
Relating biochemistry and function in the myosin superfamilyQ35705378
Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated miceQ35810540
E-cadherin adhesion activates c-Src signaling at cell-cell contactsQ35942332
Rap1 controls cell adhesion and cell motility through the regulation of myosin II.Q36118074
Myosin VI and vinculin cooperate during the morphogenesis of cadherin cell cell contacts in mammalian epithelial cellsQ36119767
Regulation of myosin II during cytokinesis in higher eukaryotesQ36151437
The Rap GTPase activator Drosophila PDZ-GEF regulates cell shape in epithelial migration and morphogenesisQ36315901
Cell-to-cell adherens junction formation and actin filament organization: similarities and differences between non-polarized fibroblasts and polarized epithelial cellsQ36702584
The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.Q37267715
Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin functionQ38346505
Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.Q39745580
Basal-to-apical cadherin flow at cell junctionsQ40198145
Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cellsQ41468891
Calcium-dependent cell-cell adhesion molecules (cadherins): subclass specificities and possible involvement of actin bundlesQ41530185
E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contactsQ43823908
Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contactsQ47438183
Cytoplasmic dynamics of myosin IIA and IIB: spatial 'sorting' of isoforms in locomoting cells.Q47847401
Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase: direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formationQ47996855
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)696-702
P577publication date2010-06-13
P1433published inNature Cell BiologyQ1574111
P1476titleMyosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens
P478volume12

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cites work (P2860)
Q35507882A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis
Q36433801A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.
Q53148839A bigger picture: classical cadherins and the dynamic actin cytoskeleton.
Q37901782A hitchhiker's guide to mechanobiology
Q37159012A mechanobiological perspective on cadherins and the actin-myosin cytoskeleton
Q36066631A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation
Q28293897Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis
Q39416065Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells
Q28117474Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions
Q35158071Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer
Q34194590Adducins Regulate Remodeling of Apical Junctions in Human Epithelial Cells
Q90750913Afadin regulates actomyosin organization through αE-catenin at adherens junctions
Q35670746Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.
Q43149268Alpha Yap: Cadherins hold it all together. Interview with Caitlin Sedwick
Q27677385An Autoinhibited Structure of  -Catenin and Its Implications for Vinculin Recruitment to Adherens Junctions
Q30586673An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions
Q35679237An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions
Q35642916An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization
Q40251223Anillin regulates cell-cell junction integrity by organizing junctional accumulation of Rho-GTP and actomyosin
Q35642922Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin
Q52314672Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier.
Q41892456Balancing spatially regulated β-actin translation and dynamin-mediated endocytosis is required to assemble functional epithelial monolayers
Q36300610Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions
Q52366658Branched actin networks push against each other at adherens junctions to maintain cell-cell adhesion.
Q37721656C9ORF135 encodes a membrane protein whose expression is related to pluripotency in human embryonic stem cells
Q36033411CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling
Q38096911Cadherin mechanotransduction in tissue remodeling.
Q38637064Cadherin-mediated cell-cell interactions in normal and cancer cells
Q58807744Cadherins in tissue architecture and disease
Q34918192Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling
Q35203646Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption
Q37611553Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens
Q92408517Common and Specific Functions of Nonmuscle Myosin II Paralogs in Cells
Q30834256Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates
Q30547509Contact inhibition of locomotion probabilities drive solitary versus collective cell migration
Q37377437Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis.
Q41712584Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II
Q37635832Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens
Q51124393Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia.
Q35763866Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics
Q91317407Differential contributions of nonmuscle myosin IIA and IIB to cytokinesis in human immortalized fibroblasts
Q33563341Differential role of nonmuscle myosin II isoforms during blebbing of MCF-7 cells
Q37155533Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity
Q38211486Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling.
Q37855367Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling
Q28115399E-cadherin interactome complexity and robustness resolved by quantitative proteomics
Q38449977E-cadherin junctions as active mechanical integrators in tissue dynamics
Q30009261Epithelial junctions and Rho family GTPases: the zonular signalosome
Q37379014FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions
Q55043002Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Q27310108Force dependent biotinylation of myosin IIA by α-catenin tagged with a promiscuous biotin ligase
Q38206254Force measurement tools to explore cadherin mechanotransduction
Q42766562Hold on tightly, let go lightly: myosin functions at adherens junctions
Q52763280In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis.
Q26825810In vivo studies on nonmuscle myosin II expression and function in heart development
Q55307144Increased α-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer.
Q30432512Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions
Q36682973Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle
Q50436523Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.
Q24293613Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF
Q52650595Mammalian nonmuscle myosin II comes in three flavors.
Q38564163Mechanical Forces and Growth in Animal Tissues
Q33834454Mechanics of tissue compaction
Q52760035Mechanosensing and Mechanotransduction at Cell-Cell Junctions.
Q38256361Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping.
Q86899397Mechanotransduction
Q41719907Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: implications for cell migration
Q28297863MicroRNA-23b regulates cellular architecture and impairs motogenic and invasive phenotypes during cancer progression
Q36222257Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis
Q36340660Modelling apical columnar epithelium mechanics from circumferential contractile fibres.
Q50891515Modelling wound closure in an epithelial cell sheet using the cellular Potts model.
Q38618037Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation.
Q27330739Multicomponent analysis of junctional movements regulated by myosin II isoforms at the epithelial zonula adherens
Q38166604Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung
Q27309011Muscular anatomy of the Podocoryna carnea hydrorhiza
Q61446445Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway
Q83229072Myosin II isoforms play distinct roles in junction biogenesis
Q39834470Myosin IIA deficient cells migrate efficiently despite reduced traction forces at cell periphery.
Q91747623Myosin IIA drives membrane bleb retraction
Q91985690Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting
Q30416190Myosin-1c regulates the dynamic stability of E-cadherin-based cell-cell contacts in polarized Madin-Darby canine kidney cells.
Q30513859Myosin-X functions in polarized epithelial cells
Q27309021Myosin-dependent remodeling of adherens junctions protects junctions from Snail-dependent disassembly
Q27004163Myosins in cell junctions
Q36147000Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.
Q53230630N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway.
Q30418563N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.
Q38187495N-cadherin, a vascular smooth muscle cell-cell adhesion molecule: function and signaling for vasomotor control.
Q42444859Na(+) /H(+) exchanger 1 (NHE1) function is necessary for maintaining mammary tissue architecture
Q37768293Neighborly relations: cadherins and mechanotransduction.
Q27322921Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension.
Q42509412Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia
Q26778962Non-muscle myosin II in disease: mechanisms and therapeutic opportunities
Q41665997Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
Q35550592Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons
Q52321911Nonmuscle myosin IIA is involved in recruitment of apical junction components through activation of α-catenin.
Q48158793Nonmuscle myosin IIB regulates epicardial integrity and epicardium-derived mesenchymal cell maturation.
Q36234461Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions
Q30418906PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium
Q30405795PTK7-Src signaling at epithelial cell contacts mediates spatial organization of actomyosin and planar cell polarity
Q42260007Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration.
Q47898096Patched1 is required in neural crest cells for the prevention of orofacial clefts
Q35119240Phosphoinositides in cell architecture.
Q39580376Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes
Q51542619Polycystins and intercellular mechanotransduction: A precise dosage of polycystin 2 is necessary for alpha-actinin reinforcement of junctions upon mechanical stimulation.
Q39647796Protein tyrosine phosphatase activity is necessary for E-cadherin-activated Src signaling
Q24293478Proteomic analysis of the enterocyte brush border
Q30498046Punctuated actin contractions during convergent extension and their permissive regulation by the non-canonical Wnt-signaling pathway.
Q27334451Quantifying cadherin mechanotransduction machinery assembly/disassembly dynamics using fluorescence covariance analysis
Q50611773Quantitative proteomic analysis reveals heat stress-induced injury in rat small intestine via activation of the MAPK and NF-κB signaling pathways.
Q54520178ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.
Q30834307ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens
Q39384298RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization
Q27313724Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages
Q39126432Rap1 in endothelial biology
Q37180598Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization
Q48150967Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier.
Q37010549Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.
Q37334741Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling
Q36650530Regional cell shape changes control form and function of Kupffer's vesicle in the zebrafish embryo.
Q35082642Regional-specific alterations in cell-cell junctions, cytoskeletal networks and myosin-mediated mechanical cues coordinate collectivity of movement of epithelial cells in response to injury.
Q47379112Regulated recruitment of SRGAP1 modulates RhoA signaling for contractility during epithelial junction maturation.
Q40455945Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling
Q36056399Rho GTP exchange factor ARHGEF11 regulates the integrity of epithelial junctions by connecting ZO-1 and RhoA-myosin II signaling
Q39212077Rho GTPases and actomyosin: Partners in regulating epithelial cell-cell junction structure and function
Q30498241Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells
Q64926631Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II.
Q35534690Spectrin-adducin membrane skeleton: A missing link between epithelial junctions and the actin cytoskeletion?
Q64994132Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.
Q30360087Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection
Q42038269Supracellular actomyosin assemblies during development
Q27310572Synaptopodin couples epithelial contractility to α-actinin-4-dependent junction maturation
Q34025612Temporal control over the initiation of cell motility by a regulator of G-protein signaling
Q37406209Tension-sensitive actin assembly supports contractility at the epithelial zonula adherens
Q24304376The Rho Target PRK2 Regulates Apical Junction Formation in Human Bronchial Epithelial Cells
Q38703949The bicellular tensile force sorts the localization of LSRs in bicellular and tricellular junctions
Q41948066The circumferential actomyosin belt in epithelial cells is regulated by the Lulu2-p114RhoGEF system
Q36685225The effect of including the C2 insert of nonmuscle myosin II-C on neuritogenesis
Q30009264The interdependence of the Rho GTPases and apicobasal cell polarity
Q89763104The multifarious regulation of the apical junctional complex
Q37909722The role of adhesion energy in controlling cell-cell contacts.
Q34362453The role of vertebrate nonmuscle Myosin II in development and human disease
Q38124067Three functions of cadherins in cell adhesion
Q36567245Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation
Q35534085Tuba and N-WASP function cooperatively to position the central lumen during epithelial cyst morphogenesis
Q42098072Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.
Q36500563Vertical uniformity of cells and nuclei in epithelial monolayers
Q38070294Vinculin, cadherin mechanotransduction and homeostasis of cell-cell junctions
Q35756679Zonula occludens-1 and -2 regulate apical cell structure and the zonula adherens cytoskeleton in polarized epithelia
Q36518604p120-catenin controls contractility along the vertical axis of epithelial lateral membranes
Q59791911p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton
Q92355126p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration
Q52375225α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart.

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