Chimeric forms of furin and TGN38 are transported with the plasma membrane in the trans-Golgi network via distinct endosomal pathways

scientific article

Chimeric forms of furin and TGN38 are transported with the plasma membrane in the trans-Golgi network via distinct endosomal pathways is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.146.2.345
P932PMC publication ID2156176
P698PubMed publication ID10465644
P5875ResearchGate publication ID12833659

P2093author name stringF R Maxfield
W G Mallet
P2860cites workCytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathwayQ24542345
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furinQ24568252
Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surfaceQ24597118
Intracellular movement of two mannose 6-phosphate receptors: return to the Golgi apparatusQ24679792
Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cellsQ24681319
Rab11 regulates recycling through the pericentriolar recycling endosomeQ24681897
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localizationQ28278951
Membrane transport in the endocytic pathwayQ29616400
Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.Q33826723
Identification, sequencing and expression of an integral membrane protein of the trans-Golgi network (TGN38)Q34063697
Intracellular trafficking of metallocarboxypeptidase D in AtT-20 cells: localization to the trans-Golgi network and recycling from the cell surface.Q34459118
Regulation of endosome sorting by a specific PP2A isoformQ34504961
Associations of elements of the Golgi apparatus with microtubulesQ36211367
Intracellular movement of cell surface receptors after endocytosis: resialylation of asialo-transferrin receptor in human erythroleukemia cellsQ36211900
Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: receptor pathwayQ36214232
Functional expression of the human transferrin receptor cDNA in Chinese hamster ovary cells deficient in endogenous transferrin receptorQ36217992
Intracellular fusion of sequentially formed endocytic compartmentsQ36218414
Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitroQ36220495
Fusion accessibility of endocytic compartments along the recycling and lysosomal endocytic pathways in intact cellsQ36221883
Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosomeQ36222118
Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalizationQ36222540
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow processQ36232964
Localization of TGN38 to the trans-Golgi network: involvement of a cytoplasmic tyrosine-containing sequenceQ36233082
COOH-terminal signals mediate the trafficking of a peptide processing enzyme in endocrine cellsQ36233213
The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.Q36234611
Aggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targetingQ36255053
An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells.Q36255652
Direct pathway from early/recycling endosomes to the Golgi apparatus revealed through the study of shiga toxin B-fragment transportQ36255884
Transferrin receptor containing the SDYQRL motif of TGN38 causes a reorganization of the recycling compartment but is not targeted to the TGNQ36257746
Golgi structure in three dimensions: functional insights from the normal rat kidney cellQ36293363
Potential sites of PI-3 kinase function in the endocytic pathway revealed by the PI-3 kinase inhibitor, wortmanninQ36382347
Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cellsQ36382633
Low density lipoprotein receptor and cation-independent mannose 6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal rates in PC12 cellsQ36531164
Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomesQ36531233
Cytoplasmic dynein-dependent vesicular transport from early to late endosomesQ36534832
Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy.Q36729142
Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitroQ37379940
Phosphatidylinositol 3-kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi networkQ37385483
An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surfaceQ37623766
Mannose 6-phosphate receptors and lysosomal enzyme targetingQ38279855
Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathwayQ39341143
Receptor-mediated endocytosis: concepts emerging from the LDL receptor systemQ39461911
TGN38/41 recycles between the cell surface and the TGN: brefeldin A affects its rate of return to the TGN.Q40365311
Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tailQ40790070
Verotoxins and their glycolipid receptors.Q40844228
TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domainQ40872991
Wortmannin retards the movement of the mannose 6-phosphate/insulin-like growth factor II receptor and its ligand out of endosomesQ41056363
Major histocompatibility complex class II compartments in human and mouse B lymphoblasts represent conventional endocytic compartmentsQ41082969
Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain.Q41269334
Phosphatidylinositol 3-kinase activity is required for early endosome fusion.Q41290141
A determinant in the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor prevents trafficking to lysosomesQ41305610
Comparative localization of mannose-6-phosphate receptor with 2,6sialyltransferase in HepG2 cells: an analysis by confocal double immunofluorescence microscopyQ41339931
Ultrastructural localization of the mannose 6-phosphate receptor in rat liverQ41450423
Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cellsQ41497903
Rab11, a small GTPase associated with both constitutive and regulated secretory pathways in PC12 cellsQ41514268
Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymQ41519880
Common signals control low density lipoprotein receptor sorting in endosomes and the Golgi complex of MDCK cellsQ41526657
Isolation of a temperature-sensitive variant Chinese hamster ovary cell line with a morphologically altered endocytic recycling compartmentQ41549199
Molecular trapping of a fluorescent ceramide analogue at the Golgi apparatus of fixed cells: interaction with endogenous lipids provides a trans-Golgi marker for both light and electron microscopyQ41589928
The trans-Golgi network can be dissected structurally and functionally from the cisternae of the Golgi complex by brefeldin AQ41599650
Recycling of transferrin receptors and heparan sulfate proteoglycans in a rat parathyroid cell line.Q41613115
Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane trafficQ41659144
Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.Q41665669
Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomesQ41680092
Microtubule-disrupting drugs blocked delivery of endocytosed transferrin to the cytocenter, but did not affect return of transferrin to plasma membraneQ41689353
Microtubule- and motor-dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cellsQ41724586
The TGN38 glycoprotein contains two non-overlapping signals that mediate localization to the trans-Golgi networkQ41907333
Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractionsQ44084029
Regulation of protein traffic in polarized epithelial cellsQ57350756
EndocytosisQ57374715
The mannose 6-phosphate receptor and the biogenesis of lysosomesQ57960197
Wortmannin-sensitive Trafficking Pathways in Chinese Hamster Ovary CellsQ63567787
Ultrastructural immunocytochemical localization of the phosphomannosyl receptor in Chinese hamster ovary (CHO) cellsQ67277894
Epitope mapping of two isoforms of a trans Golgi network specific integral membrane protein TGN38/41Q67464549
Transport of surface mannose 6-phosphate receptor to the Golgi complex in cultured human cellsQ69341005
Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopyQ71856673
Control of p62 binding to TGN38/41 by phosphorylationQ71889877
Role of clathrin-coated vesicles in glycoprotein transport from the cell surface to the Golgi complexQ72411085
The SXYQRL sequence in the cytoplasmic domain of TGN38 plays a major role in trans-Golgi network localizationQ72571291
Role of microtubules in transferrin receptor transport from the cell surface to endosomes and the Golgi complexQ72875927
The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosisQ72926635
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)345-359
P577publication date1999-07-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleChimeric forms of furin and TGN38 are transported with the plasma membrane in the trans-Golgi network via distinct endosomal pathways
P478volume146

Reverse relations

cites work (P2860)
Q35229521A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling
Q37594787A cycling cis-Golgi protein mediates endosome-to-Golgi traffic
Q34982485A di-leucine sequence and a cluster of acidic amino acids are required for dynamic retention in the endosomal recycling compartment of fibroblasts
Q40811578A dileucine motif targets E-cadherin to the basolateral cell surface in Madin-Darby canine kidney and LLC-PK1 epithelial cells.
Q44834860A dileucine motif targets the sulfate anion transporter sat-1 to the basolateral membrane in renal cell lines
Q36156809A specific role of AGS3 in the surface expression of plasma membrane proteins
Q58323010AP-1 and AP-3 Mediate Sorting of Melanosomal and Lysosomal Membrane Proteins into Distinct Post-Golgi Trafficking Pathways
Q30542954ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus
Q43721267Access of a membrane protein to secretory granules is facilitated by phosphorylation
Q36899294Alternate routes for drug delivery to the cell interior: pathways to the Golgi apparatus and endoplasmic reticulum
Q59333366Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5
Q34520112Anterograde axonal transport, transcytosis, and recycling of neurotrophic factors: the concept of trophic currencies in neural networks
Q81235764Apoptosis in tumour cells photosensitized with Rose Bengal acetate is induced by multiple organelle photodamage
Q34999872At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis
Q34729835AtVPS45 complex formation at the trans-Golgi network.
Q24564506Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network
Q24305048BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity
Q35153387Basolateral cycling mediated by a lumenal domain targeting determinant
Q24555038Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates
Q50674894Both post-Golgi and intra-Golgi cycling affect the distribution of the Golgi phosphoprotein GPP130.
Q24336448Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
Q39686069Characterization of E3/49K, a novel, highly glycosylated E3 protein of the epidemic keratoconjunctivitis-causing adenovirus type 19a.
Q42805489Characterization of the insulin-regulated endocytic recycling mechanism in 3T3-L1 adipocytes using a novel reporter molecule
Q43735192Cholesterol depletion by methyl-beta-cyclodextrin blocks cholera toxin transport from endosomes to the Golgi apparatus in hippocampal neurons
Q90197107Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum
Q24320381Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network
Q38291309Contributions of the LG modules and furin processing to laminin-2 functions
Q43003580Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool
Q24652581Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
Q40606710Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells
Q24312046Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes
Q40464576Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway.
Q35623173Dynamics of endosomal sorting
Q40082346Dynamin is functionally coupled to insulin granule exocytosis
Q90859876ER-shaping atlastin proteins act as central hubs to promote flavivirus replication and virion assembly
Q40468692Effects of mutations in the cytoplasmic domain of herpes simplex virus type 1 glycoprotein B on intracellular transport and infectivity
Q34443012Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary
Q34664121Efficient export of the vesicular stomatitis virus G protein from the endoplasmic reticulum requires a signal in the cytoplasmic tail that includes both tyrosine-based and di-acidic motifs
Q38102669Emerging roles of recycling endosomes
Q29547737Endocytic recycling
Q34190679Endocytic traffic in polarized epithelial cells: role of the actin and microtubule cytoskeleton
Q35802669Endocytosed Cation-Independent Mannose 6-Phosphate Receptor Traffics via the Endocytic Recycling Compartment en Route to thetrans-Golgi Network and a Subpopulation of Late Endosomes
Q35032078Endocytosis and sorting of glycosphingolipids in sphingolipid storage disease
Q39748126Endocytosis of adeno-associated virus type 5 leads to accumulation of virus particles in the Golgi compartment
Q30308354Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing
Q34657401Endosomal trafficking and proprotein convertase cleavage of cis Golgi protein GP73 produces marker for hepatocellular carcinoma
Q38299035Endosome to Golgi transport of ricin is independent of clathrin and of the Rab9- and Rab11-GTPases
Q38490873Endosome to Golgi transport of ricin is regulated by cholesterol
Q91650593Endosome-to-TGN Trafficking: Organelle-Vesicle and Organelle-Organelle Interactions
Q28267256Enzyme-assisted photosensitization with rose Bengal acetate induces structural and functional alteration of mitochondria in HeLa cells
Q28586215Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice
Q73517587Expression and properties of ADP-ribosylation factor (ARF6) in endocytic pathways
Q34091256FIP1/RCP binding to Golgin-97 regulates retrograde transport from recycling endosomes to the trans-Golgi network
Q34156569Facing inward from compartment shores: how many pathways were we looking for?
Q41679116Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement
Q24670432Furin at the cutting edge: from protein traffic to embryogenesis and disease
Q38928679Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene
Q35803004GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes
Q33802619Golgi network targeting and plasma membrane internalization signals in vaccinia virus B5R envelope protein
Q36750617Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion.
Q33948521Insulin-regulated release from the endosomal recycling compartment is regulated by budding of specialized vesicles
Q42804382Internalized Pseudomonas exotoxin A can exploit multiple pathways to reach the endoplasmic reticulum
Q57372567Intracellular Localization of Type III-deliveredPseudomonasExoS with Endosome Vesicles
Q35182349Intracellular trafficking of a palmitoylated membrane-associated protein component of enveloped vaccinia virus
Q24321578Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin
Q42808850Late Endosomal Recycling of Open MHC-I Conformers.
Q34368521Late endosomes: sorting and partitioning in multivesicular bodies.
Q24634104Lysosomal hydrolase mannose 6-phosphate uncovering enzyme resides in the trans-Golgi network
Q24521346MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking
Q34486783MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II.
Q37347785Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase
Q28202844Membrane transport: retromer to the rescue
Q44456267Multiple epithelial Na+ channel domains participate in subunit assembly
Q37455399Multiple routes of protein transport from endosomes to the trans Golgi network
Q34103288Multiple signals regulate trafficking of the mannose 6-phosphate-uncovering enzyme
Q36845704New insights into membrane trafficking and protein sorting.
Q42510573Nocodazole inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes via a microtubule-independent mechanism.
Q38796841Nucleic Acid Nanostructures for Chemical and Biological Sensing
Q24678185Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein
Q33934978Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking
Q24297647Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network
Q40171753Pet, a non-AB toxin, is transported and translocated into epithelial cells by a retrograde trafficking pathway.
Q24306398Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network
Q28145311Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking
Q39738033Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells
Q35964494Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC).
Q35071524Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin.
Q30306202Rapid transport of internalized P-selectin to late endosomes and the TGN: roles in regulating cell surface expression and recycling to secretory granules
Q35057749Recombinant antibody mediated delivery of organelle-specific DNA pH sensors along endocytic pathways.
Q33422481Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin
Q37155177Recycling of Raft-associated prohormone sorting receptor carboxypeptidase E requires interaction with ARF6.
Q38630111Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes
Q37083291Retrograde traffic in the biosynthetic-secretory route
Q35189416Retrograde traffic in the biosynthetic-secretory route: pathways and machinery
Q21245139Retrograde transport pathways utilised by viruses and protein toxins
Q39357458Retromer guides STxB and CD8-M6PR from early to recycling endosomes, EHD1 guides STxB from recycling endosome to Golgi
Q28506867Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells
Q51799468Role of an acidic cluster/dileucine motif in cation-independent mannose 6-phosphate receptor traffic.
Q34359883Role of cytoplasmic domain serines in intracellular trafficking of furin
Q24336478Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor
Q24291391SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P
Q38796905Sorting Motifs in the Cytoplasmic Tail of the Immunomodulatory E3/49K Protein of Species D Adenoviruses Modulate Cell Surface Expression and Ectodomain Shedding
Q33954578Sorting in the endosomal system in yeast and animal cells.
Q43792436Sorting of internalized neurotrophins into an endocytic transcytosis pathway via the Golgi system: Ultrastructural analysis in retinal ganglion cells.
Q28216490Sorting out the cellular functions of sorting nexins
Q38482840Sorting to synaptic-like microvesicles from early and late endosomes requires overlapping but not identical targeting signals.
Q24675430Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity
Q38391576The conserved dileucine- and tyrosine-based motifs in MLV and MPMV envelope glycoproteins are both important to regulate a common Env intracellular trafficking
Q28509101The cytoplasmic domain of Vamp4 and Vamp5 is responsible for their correct subcellular targeting: the N-terminal extenSion of VAMP4 contains a dominant autonomous targeting signal for the trans-Golgi network
Q28188568The earliest steps in hepatitis B virus infection
Q36078890The endocytic pathway in microglia during health, aging and Alzheimer's disease
Q33934983The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking
Q36819946The mast cell: where endocytosis and regulated exocytosis meet
Q34359076The palmitoyltransferase of the cation-dependent mannose 6-phosphate receptor cycles between the plasma membrane and endosomes
Q33950638The subapical compartment and its role in intracellular trafficking and cell polarity
Q34350937Trans-Golgi network sorting
Q40018099Transcriptional profiling of gene expression changes in a PACE-transfected CHO DUKX cell line secreting high levels of rhBMP-2.
Q34922115Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin
Q44810253Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell.

Search more.