Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans

scientific article

Inhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/ACEL.12390
P932PMC publication ID4693473
P698PubMed publication ID26361075

P50authorSeung-Jae LeeQ56997555
Murat ArtanQ57045540
P2093author name stringHong Gil Nam
Dongyeop Lee
Wooseon Hwang
Mihwa Seo
P2860cites workThe RNA polymerase II elongation complexQ34188475
Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegansQ34408851
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activityQ34683601
Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connectionQ34966704
The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancerQ35062446
Mitochondria and organismal longevity.Q36310532
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulatorsQ37671736
HIF-1 modulates longevity and healthspan in a temperature-dependent mannerQ37693738
Hypoxia signaling and resistance in C. elegansQ37718363
Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?Q37766872
Hypoxia disrupts proteostasis in Caenorhabditis elegansQ41686894
The von Hippel Lindau tumor suppressor limits longevityQ42460741
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradationQ42745906
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegansQ43959284
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.Q47069395
Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegansQ49141401
RNA polymerase II transcription factor SIII. II. Functional properties and role in RNA chain elongationQ71599526
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor functionQ22009393
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis toolsQ24248165
OASIS: online application for the survival analysis of lifespan assays performed in aging researchQ24288717
Inhibition of Transcription Elongation by the VHL Tumor Suppressor ProteinQ24336629
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screenQ24811634
Hypoxia-inducible factors in physiology and medicineQ27013770
CEP-1, the Caenorhabditis elegans p53 homolog, mediates opposing longevity outcomes in mitochondrial electron transport chain mutantsQ27317294
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegansQ27329083
Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegansQ27334849
The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin LigaseQ27651007
Clustal W and Clustal X version 2.0Q27860517
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
RNA polymerase II transcription factor SIII. I. Identification, purification, and propertiesQ28564363
Cytoscape 2.8: new features for data integration and network visualizationQ29547471
STRING v9.1: protein-protein interaction networks, with increased coverage and integrationQ29614691
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary informationQ29615720
The cell-non-autonomous nature of electron transport chain-mediated longevityQ29617238
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegansQ29618535
Proteasomal regulation of the hypoxic response modulates aging in C. elegansQ30489976
Integrative analysis of C. elegans modENCODE ChIP-seq data sets to infer gene regulatory interactions.Q30607520
PhyloWidget: web-based visualizations for the tree of lifeQ33335626
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAiQ33429561
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegansQ33487151
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegansQ33518501
The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegansQ33945482
HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storageQ34109802
P4510describes a project that usesCytoscapeQ3699942
ImageJQ1659584
P433issue6
P921main subjectCaenorhabditis elegansQ91703
P304page(s)995-1002
P577publication date2015-09-11
P1433published inAging CellQ2221073
P1476titleInhibition of elongin C promotes longevity and protein homeostasis via HIF-1 in C. elegans
P478volume14

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cites work (P2860)
Q26750863Atlas on substrate recognition subunits of CRL2 E3 ligases
Q57032017Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans
Q37062496Inverse correlation between longevity and developmental rate among wild C. elegans strains.
Q91659128KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain
Q37636598OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research
Q93381178Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans
Q37143073RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.
Q37695384RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
Q47094006RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan

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