Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia

scientific article published on 16 December 2015

Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPREGU.00388.2015
P932PMC publication ID4796742
P698PubMed publication ID26676250

P50authorFlorian HerseQ47804678
Gerd WallukatQ63288594
Ralf DechendQ63812628
P2093author name stringBabbette LaMarca
Denise C Cornelius
Lorena M Amaral
Mark W Cunningham
Ashlyn C Harmon
Jessica L Faulkner
Tarek Ibrahim
Marie M Darby
D'Andrea S Thomas
P2860cites workElucidating immune mechanisms causing hypertension during pregnancyQ26852668
Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysisQ26862535
What we have learned about preeclampsiaQ28196892
Role of endothelin in mediating soluble fms-like tyrosine kinase 1-induced hypertension in pregnant ratsQ28571017
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsiaQ29615916
Nonclassic actions of vitamin DQ33375907
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.Q33606850
Progesterone blunts vascular endothelial cell secretion of endothelin-1 in response to placental ischemiaQ33736407
Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severityQ33748680
Vitamin D supplementation during pregnancy: safety considerations in the design and interpretation of clinical trialsQ33799042
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptorQ33848380
Preeclampsia prevention and managementQ33872560
Vitamin effects on the immune system: vitamins A and D take centre stageQ34005584
A Historical Overview of Preeclampsia‐EclampsiaQ34181886
A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsiaQ34262439
CD4(+) T Cells Play a Critical Role in Mediating Hypertension in Response to Placental IschemiaQ34508485
Vitamin D Supplementation Suppresses Hypoxia-Stimulated Placental Cytokine Secretion, Hypertension and CD4(+) T Cell Stimulation in Response to Placental IschemiaQ34533258
Maternal vitamin D deficiency increases the risk of preeclampsiaQ34579840
Hypertension in response to placental ischemia during pregnancy: role of B lymphocytesQ35029700
CD4+ T-helper cells stimulated in response to placental ischemia mediate hypertension during pregnancyQ35130793
17-hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat modelQ35151065
Angiotensin II type 1 autoantibody induced hypertension during pregnancy is associated with renal endothelial dysfunctionQ35576417
Elimination of vitamin D receptor in vascular endothelial cells alters vascular functionQ35601964
Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signalingQ35681804
Potential roles of angiotensin receptor-activating autoantibody in the pathophysiology of preeclampsiaQ35681821
Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsiaQ35715914
1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence regionQ35981603
Activating autoantibodies to the angiotensin II type I receptor play an important role in mediating hypertension in response to adoptive transfer of CD4+ T lymphocytes from placental ischemic ratsQ35994304
Activating auto-antibodies against the AT1 receptor in preeclampsiaQ36010629
Endothelin: key mediator of hypertension in preeclampsiaQ36073225
Hypertension in response to CD4(+) T cells from reduced uterine perfusion pregnant rats is associated with activation of the endothelin-1 system.Q36115279
A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) modelQ36115311
Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activationQ36244980
Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP ratsQ36339273
An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsiaQ36339336
The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fms-like tyrosine-1 and soluble endoglin production in response to hypertension during pregnancyQ36407259
Free 25(OH)D and Calcium Absorption, PTH, and Markers of Bone TurnoverQ36433561
Mechanisms of disease: Pre-eclampsiaQ36577103
Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant ratsQ36683260
Immunoregulation in normal pregnancy and pre-eclampsia: an overviewQ36684096
Therapeutic effect of vitamin d supplementation in a pilot study of Crohn's patientsQ36795649
IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsiaQ36997267
Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunctionQ37022723
The role of immune activation in contributing to vascular dysfunction and the pathophysiology of hypertension during preeclampsiaQ37088970
The two stage model of preeclampsia: variations on the themeQ37187589
Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancyQ37353537
Autoantibodies to the angiotensin type I receptor in response to placental ischemia and tumor necrosis factor alpha in pregnant ratsQ37436219
Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.Q37447371
Oxidative stress contributes to soluble fms-like tyrosine kinase-1 induced vascular dysfunction in pregnant ratsQ37449693
Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy.Q37844756
Different vitamin D receptor agonists exhibit differential effects on endothelial function and aortic gene expression in 5/6 nephrectomized ratsQ38286913
MicroRNA-mediated mechanism of vitamin D regulation of innate immune responseQ38626414
Longitudinal vitamin D status in pregnancy and the risk of pre-eclampsiaQ40028522
Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functionsQ40545992
Discrimination in the metabolism of orally dosed ergocalciferol and cholecalciferol by the pig, rat and chickQ41824991
Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide.Q43576536
Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsiaQ46332630
Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial.Q47200959
Preeclampsia is associated with lower percentages of regulatory T cells in maternal bloodQ47890265
Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat.Q50514586
Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation.Q51973496
Short- and long-term changes in plasma inflammatory markers associated with preeclampsia.Q52087250
Agonistic autoantibodies to the AT1 receptor in a transgenic rat model of preeclampsia.Q52940276
First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for PreeclampsiaQ56619507
Dysregulation of the Circulating and Tissue-Based Renin-Angiotensin System in PreeclampsiaQ56981959
CD19 + CD5 + Cells as Indicators of PreeclampsiaQ59906564
Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter monthsQ60572282
Vitamin D Supplementation and Reduced Risk of Preeclampsia in Nulliparous WomenQ62565327
Prevention of preeclampsia with calcium supplementation and vitamin D3 in an antenatal protocolQ72509768
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factorQ73815485
Angiotensin II type 1 receptor agonistic antibodies reflect fundamental alterations in the uteroplacental vasculatureQ81423834
Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemiaQ82705098
P433issue4
P921main subjectpre-eclampsiaQ61335
vitamin DQ175621
P304page(s)R346-54
P577publication date2015-12-16
P1433published inAmerican Journal of Physiology - Regulatory, Integrative and Comparative PhysiologyQ2201819
P1476titleVitamin D supplementation improves pathophysiology in a rat model of preeclampsia
P478volume310

Reverse relations

cites work (P2860)
Q91564905Characterisation of the Selective Reduced Uteroplacental Perfusion (sRUPP) Model of Preeclampsia
Q38788258Meta-analysis of the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss
Q41540480New insights into the vitamin D requirements during pregnancy
Q104137018Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction
Q30382673Reduced Uterine Perfusion Pressure (RUPP) Model of Preeclampsia in Mice
Q57166484The Implications of Vitamin D Status During Pregnancy on Mother and her Developing Child
Q38953734Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications.
Q51318293Vitamin D restores angiogenic balance and decreases tumor necrosis factor-α in a rat model of pre-eclampsia.
Q51294484Vitamin D supplementation reduces some AT1-AA-induced downstream targets implicated in preeclampsia including hypertension.

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