Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia

scientific article published on 11 April 2011

Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1004026
P932PMC publication ID3269191
P698PubMed publication ID21482739
P5875ResearchGate publication ID51041534

P50authorSusan M. RaminQ110252023
P2093author name stringYang Xia
M John Hicks
Rodney E Kellems
Yingbo Dai
Roxanna A Irani
Sean C Blackwell
Cissy Chenyi Zhou
P2860cites workEndothelin 1 and angiotensin II in preeeclampsiaQ28306251
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Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptorQ33848380
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Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signalingQ36050771
Role of the renin-angiotensin system in the pathogenesis of preeclampsiaQ36064478
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Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restrictionQ36228832
The renin-angiotensin-aldosterone system in preeclampsia. A reviewQ36453940
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Inflammation and pre-eclampsiaQ36530771
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The endothelin-converting enzyme-1/endothelin-1 pathway plays a critical role in inflammation-associated premature delivery in a mouse modelQ36891528
Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunctionQ37022723
Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritisQ37169356
Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.Q37365303
Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1.Q37447371
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Etiology and pathogenesis of preeclampsia: current conceptsQ40835002
Elevated IL-6 in midtrimester amniotic fluid is involved with the onset of preeclampsiaQ40857999
Evaluation of nonspecific immunity and plasma levels of interferon-gamma, interleukin-6 and tumor necrosis factor-alpha in preeclampsiaQ44141134
Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulationQ44302005
AT1 receptor agonistic antibodies from preeclamptic patients stimulate NADPH oxidaseQ44385661
Plasma malondialdehyde, superoxide dismutase, sE-selectin, fibronectin, endothelin-1 and nitric oxide levels in women with preeclampsiaQ44809422
Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant ratsQ44895722
Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammationQ45020438
Potential role of endothelin-1 in normal and hypertensive pregnanciesQ46165905
Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretionQ46344658
Lowering of blood pressure leads to decreased circulating interleukin-6 in hypertensive subjectsQ46368521
Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: evidence for endothelin release by pancreatic islet beta-cellsQ46594619
Effects of angiotensin II receptor blockade with valsartan on pro-inflammatory cytokines in patients with essential hypertensionQ46819084
Enhanced endothelin synthesis by endothelial cells exposed to sera from pregnant rats with decreased uterine perfusionQ46877931
Women with preeclampsia have higher plasma endothelin levels than women with normal pregnanciesQ46878600
Circulating angiogenic factors and the risk of preeclampsiaQ47217679
State-of-the-Art lecture. Role of endothelin-1 in hypertensionQ48581888
Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of interleukin 6.Q51139503
Plasma nitric oxide, endothelin-1, arginase and superoxide dismutase in pre-eclamptic women.Q51436935
Increased expression of interleukin 6 in term compared to the first trimester human placental villi.Q52167315
Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsiaQ52995596
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia.Q53600812
Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats.Q54661322
IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2Q60539322
Agonist-like activity of antibodies to angiotensin II receptor subtype 1 (AT1) from rats immunized with AT1 receptor peptideQ60585302
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectpre-eclampsiaQ61335
autoantibodyQ785022
P304page(s)6024-6034
P577publication date2011-04-11
P1433published inJournal of ImmunologyQ3521441
P1476titleAutoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia
P478volume186

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cites work (P2860)
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