CUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis

scientific article published on 02 May 2016

CUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.9127
P8608Fatcat IDrelease_74y5nvfr5za7lpbfsmbthz7jzu
P932PMC publication ID5058775
P698PubMed publication ID27153550

P2093author name stringXiaodong Cheng
Ying Li
Fenfen Wang
Weiguo Lu
Xing Xie
Xinyu Wang
Junfen Xu
Qifang Tian
Yifeng Fang
P2860cites workCullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsQ22010574
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesQ24322407
American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancerQ24607403
Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin EQ58236966
HPV: The global burdenQ59062791
Human papillomavirusQ59098228
The presence of persistent high-risk HPV genotypes in dysplastic cervical lesions is associated with progressive disease: natural history up to 36 monthsQ72190175
Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemiaQ24633341
Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesisQ24680360
American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer.Q26828840
Cancer statistics, 2015Q27860576
E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancerQ28271985
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin EQ28504517
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesisQ28508809
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathwayQ28587965
miRNA-mRNA correlation-network modules in human prostate cancer and the differences between primary and metastatic tumor subtypesQ28727757
A review of human carcinogens--Part B: biological agentsQ29615608
Epidemiologic classification of human papillomavirus types associated with cervical cancerQ29616213
Human papillomavirus is a necessary cause of invasive cervical cancer worldwideQ29617514
Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent mannerQ33292435
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complexQ33489621
Systematic identification of interactions between host cell proteins and E7 oncoproteins from diverse human papillomaviruses.Q34122679
The genetics of the E2F family of transcription factors: shared functions and unique rolesQ34646667
E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosisQ35015916
Oncogenic aberrations of cullin-dependent ubiquitin ligasesQ35691547
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressorQ36098917
Conserved region 3 of human papillomavirus 16 E7 contributes to deregulation of the retinoblastoma tumor suppressorQ36414554
The invisible enemy - how human papillomaviruses avoid recognition and clearance by the host immune systemQ36541450
A systematic evaluation of miRNA:mRNA interactions involved in the migration and invasion of breast cancer cellsQ36690663
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemiaQ36948708
Updating the natural history of human papillomavirus and anogenital cancersQ36979148
Human papillomavirus oncoproteins: pathways to transformationQ37769103
The cullin protein familyQ37873586
Screening for possible miRNA-mRNA associations in a colon cancer cell lineQ39111162
Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancerQ39370408
Serotype-specific inactivation of the cellular DNA damage response during adenovirus infectionQ39619768
Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update.Q40227526
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradationQ42745906
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity.Q42751771
E2F1 is crucial for E2F-dependent apoptosisQ43167748
CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegansQ47068715
Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegansQ47069321
CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegansQ47069420
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectcarcinogenesisQ1637543
overexpressionQ61643320
P304page(s)31520-31533
P577publication date2016-05-02
P1433published inOncotargetQ1573155
P1476titleCUL2 overexpression driven by CUL2/E2F1/miR-424 regulatory loop promotes HPV16 E7 induced cervical carcinogenesis
P478volume7

Reverse relations

cites work (P2860)
Q92367695Association of mRNA expression levels of Cullin family members with prognosis in breast cancer: An online database analysis
Q54942210Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy.
Q89834860HPV Oncoproteins and the Ubiquitin Proteasome System: A Signature of Malignancy?
Q58693977Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS
Q58798155The lysine acetyltransferase GCN5 contributes to human papillomavirus oncoprotein E7-induced cell proliferation via up-regulating E2F1
Q47801891Whole-exome analysis of a Li-Fraumeni family trio with a novel TP53 PRD mutation and anticipation profile.
Q59800180miR-424 targets AKT3 and PSAT1 and has a tumor-suppressive role in human colorectal cancer

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