Antiviral RNAi: Translating Science Towards Therapeutic Success

scientific article published on 09 August 2011

Antiviral RNAi: Translating Science Towards Therapeutic Success is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11095-011-0549-8
P953full work available at URLhttp://link.springer.com/article/10.1007/s11095-011-0549-8/fulltext.html
http://link.springer.com/content/pdf/10.1007/s11095-011-0549-8
http://link.springer.com/content/pdf/10.1007/s11095-011-0549-8.pdf
https://europepmc.org/articles/PMC5012899
https://europepmc.org/articles/PMC5012899?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012899
P932PMC publication ID5012899
P698PubMed publication ID21826573
P5875ResearchGate publication ID51556946

P50authorDavid SchafferQ59749936
P2093author name stringDavid V. Schaffer
Priya S. Shah
P2860cites workDrug research. Roche exits RNAi field, cuts 4800 jobsQ82616900
Transcriptional and Posttranscriptional Plant Gene Silencing in Response to a PathogenQ95431973
Hairpin RNA-mediated silencing of Plum pox virus P1 and HC-Pro genes for efficient and predictable resistance to the virus.Q45422109
Dual modes of RNA-silencing suppression by Flock House virus protein B2.Q45423252
Silencing of yellow head virus replication in penaeid shrimp cells by dsRNA.Q45439835
Inhibition of the Epstein-Barr virus lytic cycle by Zta-targeted RNA interferenceQ45634908
Inhibition of hepatitis B virus expression and replication by RNA interferenceQ45728501
Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrowQ45887432
Inhibition of drug-resistant HIV-1 by RNA interferenceQ46806254
Inhibition of respiratory viruses by nasally administered siRNA.Q47874231
Silencing of HTLV-1 gag and env genes by small interfering RNAs in HEK 293 cellsQ50527698
Evidence that HIV-1 encodes an siRNA and a suppressor of RNA silencingQ50768291
Inhibition of SARS-associated coronavirus infection and replication by RNA interference.Q51641137
Twenty years of therapy for HIV-1 infectionQ53382316
Stringent testing identifies highly potent and escape-proof anti-HIV short hairpin RNAsQ53399030
Chemical modification of siRNAs to improve serum stability without loss of efficacyQ53600125
HIV Drug ResistanceQ59448085
Viral evolution under the pressure of an adaptive immune system: Optimal mutation rates for viral escapeQ59867771
Development of interfering RNA agents to inhibit SARS-associated coronavirus infection and replicationQ63561195
Genome-scale RNAi screen for host factors required for HIV replicationQ79769455
Recombinant lentivirus-delivered short hairpin RNAs targeted to conserved coxsackievirus sequences protect against viral myocarditis and improve survival rate in an animal modelQ80439723
Inhibition of herpesvirus-6B RNA replication by short interference RNAsQ80832451
Selective silencing of viral gene E6 and E7 expression in HPV-positive human cervical carcinoma cells using small interfering RNAsQ80913745
Inhibition of porcine circovirus type 2 replication in mice by RNA interferenceQ82329354
A similarity between viral defense and gene silencing in plantsQ34793599
Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3.Q34991742
Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian ArgonautesQ35022080
Effective suppression of human immunodeficiency virus type 1 through a combination of short- or long-hairpin RNAs targeting essential sequences for retroviral integrationQ35023698
An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized miceQ35111705
Control of nonsegmented negative-strand RNA virus replication by siRNA.Q35739895
RNA silencing of rotavirus gene expressionQ35739901
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISCQ35990922
Interferon antagonist proteins of influenza and vaccinia viruses are suppressors of RNA silencingQ36018096
Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors--design, biosafety, and production.Q36186475
Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5.Q36457063
Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interferenceQ36483991
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vectorQ36663364
RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapyQ36673668
RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cellsQ36684320
Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plantsQ36708618
Stability and loss of a virus resistance phenotype over time in transgenic mosquitoes harbouring an antiviral effector geneQ36821669
Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1).Q36954414
Impact of target mRNA structure on siRNA silencing efficiency: A large-scale studyQ37135903
The business of RNAi therapeuticsQ37147185
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicityQ37199509
A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAsQ37331638
Rational design leads to more potent RNA interference against hepatitis B virus: factors effecting silencing efficiencyQ37405760
Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment successQ37417692
Inhibition of monkeypox virus replication by RNA interferenceQ37422402
Rapid creation and quantitative monitoring of high coverage shRNA librariesQ37440284
Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesisQ37596477
Inhibiting the Arp2/3 complex limits infection of both intracellular mature vaccinia virus and primate lentivirusesQ37657108
Staying on message: design principles for controlling nonspecific responses to siRNAQ37809577
Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistronQ38621943
Bispecific short hairpin siRNA constructs targeted to CD4, CXCR4, and CCR5 confer HIV-1 resistanceQ38874585
Combinatorial RNAi against HIV-1 using extended short hairpin RNAsQ39502428
Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factorsQ39629447
Anticipating and blocking HIV-1 escape by second generation antiviral shRNAsQ39696110
The nuclear RNase III Drosha initiates microRNA processingQ24295234
Identification of host proteins required for HIV infection through a functional genomic screenQ24306298
Cellular cofactors affecting hepatitis C virus infection and replicationQ24317564
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail functionQ24538996
Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegansQ24542489
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesQ24554481
MicroRNA genes are transcribed by RNA polymerase IIQ24562649
T cell-specific siRNA delivery suppresses HIV-1 infection in humanized miceQ24603574
Directed evolution of adeno-associated virus to an infectious respiratory virusQ24649385
On the origin and functions of RNA-mediated silencing: from protists to manQ24657546
MicroRNAs in plantsQ24674274
Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in transQ24677038
siVirus: web-based antiviral siRNA design software for highly divergent viral sequencesQ24680302
Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral productionQ24682936
Sam68 is absolutely required for Rev function and HIV-1 productionQ24791042
A theoretical approach to predicting the success of genetic manipulation of malaria mosquitoes in malaria controlQ24791629
HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genomeQ24802185
A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sitesQ24804835
A single siRNA suppresses fatal encephalitis induced by two different flavivirusesQ25255046
Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding RegionQ27469608
Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegyptiQ27473167
Interference of hepatitis C virus RNA replication by short interfering RNAsQ27473349
Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoesQ27487509
Optimization of linear double-stranded RNA for the production of multiple siRNAs targeting hepatitis C virusQ27488340
Combined antiviral activity of interferon-α and RNA interference directed against hepatitis C without affecting vector delivery and gene silencingQ27488834
The role of RNAi and microRNAs in animal virus replication and antiviral immunityQ27490179
Targeted Delivery of Small Interfering RNA to Human Dendritic Cells To Suppress Dengue Virus Infection and Associated Proinflammatory Cytokine ProductionQ27490919
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNAQ27860813
Role for a bidentate ribonuclease in the initiation step of RNA interferenceQ27860832
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansQ27860867
A system for stable expression of short interfering RNAs in mammalian cellsQ27860875
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegansQ27860895
Identification of Novel Genes Coding for Small Expressed RNAsQ27860917
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
How cells respond to interferonsQ27861006
Functional siRNAs and miRNAs Exhibit Strand BiasQ27861038
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
Purified Argonaute2 and an siRNA form recombinant human RISCQ28242666
Inhibition of translational initiation by Let-7 MicroRNA in human cellsQ28265842
Second-generation shRNA libraries covering the mouse and human genomesQ28275183
A viral suppressor of gene silencing in plantsQ28286683
Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanismsQ28295748
Development of a low bias method for characterizing viral populations using next generation sequencing technologyQ28748746
Rational siRNA design for RNA interferenceQ29614450
Crystal structure of Argonaute and its implications for RISC slicer activityQ29614980
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantationQ29615068
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infectionQ29615959
Expression profiling reveals off-target gene regulation by RNAiQ29615965
Rates of evolutionary change in viruses: patterns and determinantsQ29616174
RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiaeQ29616263
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replicationQ29616375
RNA interference screen for human genes associated with West Nile virus infectionQ29616376
Induction and suppression of RNA silencing by an animal virusQ29618494
Functional neurogenesis in the adult hippocampusQ29618708
Optimal design and validation of antiviral siRNA for targeting HIV-1.Q30365737
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.Q30384547
Caveolin-1 influences human influenza A virus (H1N1) multiplication in cell cultureQ30389699
Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in DrosophilaQ30556603
Restriction enzyme-generated siRNA (REGS) vectors and librariesQ33196416
Enzymatic production of RNAi libraries from cDNAs.Q33196418
Small interfering RNA production by enzymatic engineering of DNA (SPEED)Q33199649
Designing siRNA that distinguish between genes that differ by a single nucleotideQ33257088
The Ebola virus VP35 protein is a suppressor of RNA silencingQ33288729
Comparison of chicken 7SK and U6 RNA polymerase III promoters for short hairpin RNA expressionQ33306167
Host cell factors in HIV replication: meta-analysis of genome-wide studiesQ33455551
Small interfering RNA targeting m2 gene induces effective and long term inhibition of influenza A virus replication.Q33455759
Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration propertiesQ33628417
Inhibition of SARS-CoV replication by siRNA.Q45206542
The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brainQ45280305
Inhibition of Newcastle disease virus replication by RNA interference targeting the matrix protein gene in chicken embryo fibroblastsQ45378471
Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccineQ45388986
Effective inhibition of infectious bursal disease virus replication in vitro by DNA vector-based RNA interferenceQ45396139
Inhibition of enterovirus 71 in virus-infected mice by RNA interference.Q45401009
Stable inhibition of hepatitis B virus expression and replication in HepG2.2.15 cells by RNA interference based on retrovirus deliveryQ45410987
Development of potential antiviral strategy against coxsackievirus B4.Q39730331
Inhibition of Hepatitis E virus replication using short hairpin RNA (shRNA).Q39747338
Effective siRNAs inhibit the replication of novel influenza A (H1N1) virusQ39754286
RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequencesQ39816401
Inhibition of rabies virus replication by multiple artificial microRNAsQ39818328
Identification of small interfering RNAs which inhibit the replication of several Enterovirus 71 strains in China.Q39843765
Suppression of RNA silencing by Flock house virus B2 protein is mediated through its interaction with the PAZ domain of DicerQ39887463
Evolutionary dynamics of complex networks of HIV drug-resistant strains: the case of San FranciscoQ39909667
RNA interference protects horse cells in vitro from infection with Equine Arteritis VirusQ39917317
HIV evades RNA interference directed at TAR by an indirect compensatory mechanism.Q39919699
Vector design for liver-specific expression of multiple interfering RNAs that target hepatitis B virus transcriptsQ39979308
Development of RNA interference (RNAi) as potential antiviral strategy against enterovirus 70.Q39989780
Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytesQ39992106
Human immunodeficiency virus type 1 escape from RNA interferenceQ40011912
Specific small interfering RNAs-mediated inhibition of replication of porcine encephalomyocarditis virus in BHK-21 cellsQ40017520
HIV-1 resistance to the anti-HIV activity of a shRNA targeting a dual-coding regionQ40037564
Antiviral therapy: inhibition of Hepatitis C Virus expression by RNA interference directed against the NS5B region of the viral genomeQ40085164
Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and miceQ40089500
Inhibition of hepatitis C virus infection in cell culture by small interfering RNAsQ40132466
Inhibition of avian leukosis virus replication by vector-based RNA interferenceQ40134516
Inhibition of porcine circovirus type 1 and type 2 production in PK-15 cells by small interfering RNAs targeting the Rep geneQ40139396
Silencing of HIV-1 with RNA interference: a multiple shRNA approachQ40234514
The virion-associated incoming HIV-1 RNA genome is not targeted by RNA interferenceQ40237024
Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes.Q40250791
Hepatitis B virus is inhibited by RNA interference in cell culture and in miceQ40255282
Interference of porcine reproductive and respiratory syndrome virus replication on MARC-145 cells using DNA-based short interfering RNAs.Q40274880
Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral responseQ40306305
Effective siRNA targeting of the 3' untranslated region of the West Nile virus genomeQ40399935
Impact of gene-modified T cells on HIV infection dynamicsQ40408633
Drosophila U6 promoter-driven short hairpin RNAs effectively induce RNA interference in Schneider 2 cellsQ40424836
Rotavirus gene silencing by small interfering RNAsQ40429464
RNA interference-mediated control of hepatitis B virus and emergence of resistant mutant.Q40447169
Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape.Q40454547
Paradigms for conditional expression of RNA interference molecules for use against viral targets.Q40472917
La Crosse virus nonstructural protein NSs counteracts the effects of short interfering RNA.Q40481133
RNA interference-mediated virus clearance from cells both acutely and chronically infected with the prototypic arenavirus lymphocytic choriomeningitis virusQ40501127
Inhibition of foot-and-mouth disease virus replication by small interfering RNA.Q40504597
Inhibition of Marburg virus protein expression and viral release by RNA interferenceQ40512402
Prophylactic and therapeutic effects of small interfering RNA targeting SARS-coronavirusQ40534160
Down-regulation of viral replication by adenoviral-mediated expression of siRNA against cellular cofactors for hepatitis C virusQ40581785
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibitionQ40589914
Inhibition of human cytomegalovirus replication by small interfering RNAsQ40600110
Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivoQ40606944
Enhanced gene silencing by the application of multiple specific small interfering RNAsQ40628982
Inhibition of hepatitis B virus in mice by RNA interferenceQ40648698
Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interferenceQ40695522
Modulation of HIV-1 replication by RNA interferenceQ40721798
Short interfering RNA confers intracellular antiviral immunity in human cellsQ40721804
Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approachesQ40723068
An endoplasmic reticulum-specific stress-activated caspase (caspase-12) is implicated in the apoptosis of A549 epithelial cells by respiratory syncytial virusQ40834923
Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchipsQ42069867
Emerging Influenza Antiviral Resistance ThreatsQ42725866
Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytesQ42739394
Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C.Q43039541
RNA interference in mammalian cells by chemically-modified RNA.Q44496696
Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activationQ44552994
Small interfering RNA molecules as potential anti-human rhinovirus agents: in vitro potency, specificity, and mechanismQ44572527
Probing the sequence space available for HIV-1 evolutionQ44674520
A novel program to design siRNAs simultaneously effective to highly variable virus genomesQ44990767
Quasispecies theory and the behavior of RNA virusesQ33641547
Computational models of HIV-1 resistance to gene therapy elucidate therapy design principlesQ33658642
Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA libraryQ33719287
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT miceQ33730699
An Evolved Adeno-associated Viral Variant Enhances Gene Delivery and Gene Targeting in Neural Stem CellsQ33790771
The cellular HIV-1 Rev cofactor hRIP is required for viral replication.Q33926825
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virusQ33928650
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cellsQ33938488
Identification and characterization of human cytomegalovirus-encoded microRNAsQ33987509
RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphomaQ34121209
In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapyQ34221633
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cellsQ34227843
An antiviral role for the RNA interference machinery in Caenorhabditis elegansQ34234621
Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursorsQ34246650
Conjugate-based targeting of recombinant adeno-associated virus type 2 vectors by using avidin-linked ligandsQ34354192
Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3.Q34355955
RNA interference targeting VP1 inhibits foot-and-mouth disease virus replication in BHK-21 cells and suckling miceQ34437582
Inhibition of influenza virus production in virus-infected mice by RNA interferenceQ34514513
Protection against lethal influenza virus challenge by RNA interference in vivo.Q34514565
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathwaysQ34530552
Adenovirus-mediated RNA interference against foot-and-mouth disease virus infection both in vitro and in vivoQ34545659
Multiple shRNA combinations for near-complete coverage of all HIV-1 strainsQ34552467
SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cellsQ34558129
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAsQ34593731
Transvascular delivery of small interfering RNA to the central nervous system.Q34638044
Molecular basis for target RNA recognition and cleavage by human RISC.Q34654514
RNAi-based therapeutics-current status, challenges and prospectsQ34659612
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytesQ34695803
Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibitionQ34733983
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectRNA interferenceQ201993
P304page(s)2966-2982
P577publication date2011-08-09
P13046publication type of scholarly workreview articleQ7318358
P1433published inPharmaceutical ResearchQ7180737
P1476titleAntiviral RNAi: translating science towards therapeutic success
Antiviral RNAi: Translating Science Towards Therapeutic Success
P478volume28

Reverse relations

cites work (P2860)
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