The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis

scientific article published on June 1, 2012

The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TIG.2012.04.004
P953full work available online athttps://api.elsevier.com/content/article/PII:S0168952512000686?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0168952512000686?httpAccept=text/xml
P698PubMed publication ID22658804

P2093author name stringYou-Ying Chau
Nicholas D. Hastie
P2860cites workWT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosisQ24292676
Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin geneQ24304157
De novo cardiomyocytes from within the activated adult heart after injuryQ24605971
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
The basics of epithelial-mesenchymal transitionQ24652992
Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transitionQ24685187
Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1Q27335370
The genetics of Wilms' tumor--a case of disrupted developmentQ40614052
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.Q40895648
Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidneyQ41006079
A myocardial lineage derives from Tbx18 epicardial cellsQ41213731
Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2.Q42052856
Coronary arteries form by developmental reprogramming of venous cellsQ42530831
Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.Q42945812
A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repressionQ43221537
Role of the WT1 tumor suppressor in murine hematopoiesisQ44240277
Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytesQ44968839
Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesisQ46889320
The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.Q48369257
The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesisQ50682333
The Wilms' tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarctionQ51715205
Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives.Q51795587
Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiationQ52097211
The Wilms tumor suppressor gene wt1 is required for development of the spleenQ52174780
WT1 mutations in Meacham syndrome suggest a coelomic mesothelial origin of the cardiac and diaphragmatic malformationsQ55671351
Loss of WT1 function leads to ectopic myogenesis in Wilms' tumourQ59662077
The Wilms' tumour suppressor WT1 is involved in endothelial cell proliferation and migration: expression in tumour vessels in vivoQ63487627
Origin of coronary endothelial cells from epicardial mesothelium in avian embryosQ78810466
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4Q28508296
Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formationQ28509874
WT-1 is required for early kidney developmentQ28512266
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney developmentQ28590640
Liver regenerationQ29614743
Osteoblastic cells regulate the haematopoietic stem cell nicheQ29615007
Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liverQ29616840
Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironmentQ29620053
Transient regenerative potential of the neonatal mouse heartQ29620371
Epicardial spindle orientation controls cell entry into the myocardiumQ30495669
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney developmentQ33904019
The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cellsQ34077533
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblastsQ34125363
Circulating levels of IGF-1 directly regulate bone growth and densityQ34149771
Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cellsQ34261674
Hematopoiesis is severely altered in mice with an induced osteoblast deficiencyQ34290169
Life, sex, and WT1 isoforms--three amino acids can make all the differenceQ34348689
Transitions between epithelial and mesenchymal states in development and diseaseQ34761972
Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in Metazoans.Q34969022
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon geneQ35095712
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.Q35779219
New insights into epithelial-mesenchymal transition in kidney fibrosisQ36010095
Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histologyQ36108223
Transcriptional regulation by WT1 in development.Q36229114
Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuriaQ36559707
Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growthQ36807644
The role of the Wilms tumour gene (WT1) in normal and malignant haematopoiesisQ36831216
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.Q36952843
The post-transcriptional roles of WT1, a multifunctional zinc-finger proteinQ36991082
New insights into the function of the Wilms tumor suppressor gene WT1 in podocytesQ37127104
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.Q37504561
WT1 in disease: shifting the epithelial-mesenchymal balance.Q37940867
An isoform of the Wilms' tumor suppressor gene potentiates granulocytic differentiationQ38354567
Wt1 Flip-Flops Chromatin in a CTCF DomainQ38493322
WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.Q39371450
Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1.Q40292711
The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1.Q40484861
P433issue10
P407language of work or nameEnglishQ1860
P921main subjecttissue homeostasisQ14873636
P304page(s)515-524
P577publication date2012-06-01
P1433published inTrends in GeneticsQ2451468
P1476titleThe role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis
P478volume28

Reverse relations

cites work (P2860)
Q27009003A role of WT1 in cell division and genomic stability
Q35666497Association between WT1 polymorphisms and susceptibility to breast cancer: results from a case-control study in a southwestern Chinese population
Q46571589Bone marrow WT1 levels at diagnosis, post-induction and post-intensification in adult de novo AML.
Q47294532DNA and RNA binding by the Wilms' tumour gene 1 (WT1) protein +KTS and -KTS isoforms-From initial observations to recent global genomic analyses
Q34048409Discovery of co-occurring driver pathways in cancer
Q39405563Distinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells
Q90730645Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1
Q92249212Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multi-Tumor Associated Antigen Specific Cytotoxic T Lymphocytes: A Phase I Study
Q35940782Molecular changes in endometriosis-associated ovarian clear cell carcinoma.
Q93368809New therapeutics based on emerging concepts in pulmonary fibrosis
Q41682903SOX2 suppresses the mobility of urothelial carcinoma by promoting the expression of S100A14.
Q38897318The Role of WT1 in Embryonic Development and Normal Organ Homeostasis
Q47388677The transcriptional coregulator NAB2 is a target gene for the Wilms' tumor gene 1 protein (WT1) in leukemic cells
Q38712379Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction
Q50971977Turning back the Wheel: Inducing Mesenchymal to Epithelial Transition via Wilms Tumor 1 Knockdown in Human Mesothelioma Cell Lines to Influence Proliferation, Invasiveness, and Chemotaxis
Q30580914Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source.
Q37721627WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel
Q58093530WT1 expression in vessels varies with histopathological grade in tumour-bearing and control tissue from patients with breast cancer
Q34221445WT1 interacts with MAD2 and regulates mitotic checkpoint function
Q92314698Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish
Q35157134Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.
Q56981752Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease
Q47948619Wilms' tumour 1 (WT1) in development, homeostasis and disease.

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