Sweet-taste-suppressing compounds: current knowledge and perspectives of application

scientific article published on 18 September 2012

Sweet-taste-suppressing compounds: current knowledge and perspectives of application is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011681334
P356DOI10.1007/S00253-012-4387-3
P698PubMed publication ID22983596
P5875ResearchGate publication ID230864205

P50authorWolfgang MeyerhofQ88318579
P2093author name stringLoïc Briand
Anne Brockhoff
Maud Sigoillot
P2860cites workHuman receptors for sweet and umami tasteQ22337199
An amino-acid taste receptorQ22337237
The receptors and cells for mammalian tasteQ22337248
The cysteine-rich region of T1R3 determines responses to intensely sweet proteinsQ24300689
Different functional roles of T1R subunits in the heteromeric taste receptorsQ24564155
T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1Q24682744
Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptorQ24791516
High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptideQ27619654
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptorQ27627995
Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptideQ27730279
The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channelQ27748197
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Characteristics of antisweet substances, sweet proteins, and sweetness-inducing proteinsQ28156690
Sweet taste receptor gene variation and aspartame taste in primates and other speciesQ28388576
Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compoundsQ28482473
Mammalian sweet taste receptorsQ29614809
Isolation and structure elucidation of gymnemic acids, antisweet principles of Gymnema sylvestre.Q30832219
The cystine knot motif in toxins and implications for drug design.Q31425913
Genetically-increased taste cell population with G(alpha)-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in miceQ33520351
Positive allosteric modulators of the human sweet taste receptor enhance sweet tasteQ33532996
Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivityQ33705535
Molecular mechanism of the sweet taste enhancersQ33740765
Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptorQ33888964
Recombinant protein expression in Pichia pastorisQ33926665
Identification of a novel member of the T1R family of putative taste receptorsQ33944978
Sweeteners: state of knowledge reviewQ34061100
Sweet and umami taste: natural products, their chemosensory targets, and beyondQ34165889
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Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.Q34387670
A TAS1R receptor-based explanation of sweet 'water-taste'.Q34516801
Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colonQ34531002
Differential gurmarin suppression of sweet taste responses in rat solitary nucleus neurons.Q34532992
Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domainQ34627992
The G-protein coupling properties of the human sweet and amino acid taste receptorsQ34628829
Taste in chimpanzees. III: Labeled-line coding in sweet tasteQ34755893
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptorsQ35143358
Molecular mechanism of species-dependent sweet taste toward artificial sweetenersQ35146513
Ligand-selective receptor conformations revisited: the promise and the problemQ35181787
Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning.Q36642706
The heterodimeric sweet taste receptor has multiple potential ligand binding sites.Q36683638
Gymnema sylvestre for diabetes mellitus: a systematic reviewQ37019099
Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3Q37440602
Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus.Q37790584
Dimers and beyond: The functional puzzles of class C GPCRs.Q37831552
Gustatory and extragustatory functions of mammalian taste receptorsQ37842841
Dissecting protein-protein interactions using directed evolution.Q37844524
Non-caloric sweeteners, sweetness modulators, and sweetener enhancersQ37973754
Electrophysiological characterization of the inhibitory effect of a novel peptide gurmarin on the sweet taste response in ratsQ38296861
Recombinant expression, in vitro refolding, and biophysical characterization of the N-terminal domain of T1R3 taste receptorQ38326655
Reduction of the suppressive effects of gurmarin on sweet taste responses by addition of beta-cyclodextrinQ38335438
Induction of salivary gurmarin-binding proteins in rats fed gymnema-containing dietsQ39123745
Variation in gymnemic acid content and non-destructive harvesting of Gymnema sylvestre (Gudmar).Q39335836
Amiloride reduces the sweet taste intensity by inhibiting the human sweet taste receptor.Q39701358
Interactions of the sweet-tasting proteins thaumatin and lysozyme with the human sweet-taste receptor.Q39843954
Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells.Q40466661
Diversity and selectivity of receptor-G protein interactionQ41048215
The liaison of sweet and savoryQ42676895
Extracellular production of riboflavin-binding protein, a potential bitter inhibitor, by Brevibacillus choshinensisQ43203220
Structural analysis of free and enzyme-bound amaranth alpha-amylase inhibitor: classification within the knottin fold superfamily and analysis of its functional flexibilityQ43798675
Reduction of sweetness judgements by extracts from the leaves of Ziziphus jujubaQ44259792
Gurmarin Suppression of Licking Responses to Sweetener-Quinine Mixtures in C57BL MiceQ44417133
Synergistic Responses of the Chorda Tympani to Mixtures of Umami and Sweet Substances in RatsQ44417137
An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestineQ44722423
Oral zinc sulfate solutions inhibit sweet taste perceptionQ44989572
Mouse strain differences in Gurmarin-sensitivity of sweet taste responses are not associated with polymorphisms of the sweet receptor gene, Tas1r3.Q46525237
Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3.Q46632164
Antagonism of the gerbil's sweetener and Polycose gustatory responses by copper chlorideQ48934391
Taste in chimpanzee: I. The summated response to sweeteners and the effect of gymnemic acid.Q52845696
Induction of salivary kallikreins by the diet containing a sweet-suppressive peptide, gurmarin, in the rat.Q53618644
Depression of gustatory sweet response by alloxan.Q54321759
Effects of gymnemic acid on the chorda tympani proper nerve responses to sweet, sour, salty and bitter taste stimuli in the chimpanzee.Q54688098
Selective Inhibition of Sweetness by the Sodium Salt of +/-2-(4-Methoxyphenoxy)propanoic AcidQ57075009
Carboxylic acid replacement structure-activity relationships in suosan type sweeteners. A sweet taste antagonist. 1Q57483193
Genomic, genetic and functional dissection of bitter taste responses to artificial sweetenersQ57822922
Optimization of the production of gurmarin, a sweet-taste-suppressing protein, secreted by the methylotrophic yeast Pichia pastorisQ57980418
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)619-630
P577publication date2012-09-18
P1433published inApplied Microbiology and BiotechnologyQ13553694
P1476titleSweet-taste-suppressing compounds: current knowledge and perspectives of application
P478volume96

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cites work (P2860)
Q38824166Chemosensory signalling pathways involved in sensing of amino acids by the ghrelin cell
Q26824794Functional roles of the sweet taste receptor in oral and extraoral tissues
Q26864827Minireview: Nutrient sensing by G protein-coupled receptors
Q92720672Secretion of Gut Hormones and Expression of Sweet Taste Receptors and Glucose Transporters in a Rat Model of Obesity
Q55457762Sweet taste receptor inhibitors: Potential treatment for equine insulin dysregulation.
Q38810068What Does Diabetes "Taste" Like?

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