Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis

scientific article

Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-09-2684
P932PMC publication ID2881466
P698PubMed publication ID20179210

P50authorWilliam BamletQ48925451
Thomas C. SmyrkQ64371564
P2093author name stringAlan P Fields
Nicole R Murray
Michele L Scotti
P2860cites workProtein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cellsQ24310371
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colonQ34749595
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iotaQ34828123
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude miceQ35575178
Molecular-targeted agents in pancreatic cancerQ35641998
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivoQ36322263
Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesisQ36325748
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cellsQ37143104
Protein kinase Cbeta is an effective target for chemoprevention of colon cancerQ37349308
Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancerQ37361313
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesisQ37373237
Long-term survival and prognostic indicators in small (Q37464630
Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasisQ38337872
Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosisQ38340918
Atypical protein kinases Clambda and -zeta associate with the GTP-binding protein Cdc42 and mediate stress fiber lossQ39452193
Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cellsQ39879775
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.Q40144497
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.Q40285051
Molecular target-based therapy of pancreatic cancerQ40314224
A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cellsQ40321941
p8 is a new target of gemcitabine in pancreatic cancer cellsQ40333276
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancerQ40365768
Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicityQ40402576
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activityQ40515725
Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell linesQ40552196
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathwayQ40575136
Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1Q40647436
Telomerase activity of cultured human pancreatic carcinoma cell lines correlates with their potential for migration and invasionQ40828591
Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.Q42056986
Epithelial-mesenchymal transition (EMT) and activated extracellular signal-regulated kinase (p-Erk) in surgically resected pancreatic cancerQ42631961
K-ras mutations in pancreatic ductal proliferative lesionsQ42753837
Reversion of Ras- and phosphatidylcholine-hydrolyzing phospholipase C-mediated transformation of NIH 3T3 cells by a dominant interfering mutant of protein kinase C lambda is accompanied by the loss of constitutive nuclear mitogen-activated protein kQ42801458
The use of a tropism-modified measles virus in folate receptor-targeted virotherapy of ovarian cancerQ45410754
Characterization of the CXCR4 signaling in pancreatic cancer cellsQ46823256
Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma.Q53594703
Aurothiomalate Inhibits Transformed Growth by Targeting the PB1 Domain of Protein Kinase CιQ57271956
Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic cancer cell lines with Ki-ras mutation but not those without Ki-ras mutationQ73864505
Protein kinase C isoforms involved in the transcriptional activation of cyclin D1 by transforming Ha-RasQ74499731
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)2064-2074
P577publication date2010-02-23
P1433published inCancer ResearchQ326097
P1476titleProtein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis
P478volume70

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cites work (P2860)
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Q58697716PKCι and YAP1 are crucial in promoting pancreatic tumorigenesis
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Q47805359miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells

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