Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro

scientific article published on May 1998

Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.141.4.863
P932PMC publication ID2132762
P698PubMed publication ID9585406
P5875ResearchGate publication ID277480324

P2093author name stringGerace L
Dickmanns A
Kehlenbach RH
P2860cites workNuclear export of NF-ATc enhanced by glycogen synthase kinase-3Q24309262
A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathwayQ24309825
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factorQ24316152
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62Q24317417
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2Q24317523
Sequence and characterization of cytoplasmic nuclear protein import factor p97Q24318868
Karyopherin beta2 mediates nuclear import of a mRNA binding proteinQ24319692
Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5AQ24321701
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88Q24322912
Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complexQ41075696
Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein exportQ41104206
Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4.Q41183095
The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N.Q41194076
Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibodyQ41666777
Stimulation of tissue-type plasminogen activator gene expression by sodium butyrate and trichostatin A in human endothelial cells involves histone acetylationQ41808615
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleusQ42772140
Rapid targeting of nuclear proteins to the cytoplasmQ46400037
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin AQ46979889
Energy- and temperature-dependent in vitro export of RNA from synthetic nucleiQ48955413
Reversible inhibition of protein import into the nucleus by wheat germ agglutinin injected into cultured cellsQ69012640
O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteinsQ70345116
Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1Q72403668
Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysisQ74033395
A novel receptor-mediated nuclear protein import pathwayQ24324050
A molecular mechanism for the effect of lithium on developmentQ24629067
Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activationQ24657633
Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteinsQ24671748
A nuclear localization domain in the hnRNP A1 proteinQ24672627
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
Nuclear targeting sequences--a consensus?Q27860997
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
NF-AT components define a family of transcription factors targeted in T-cell activationQ28114991
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
From nucleoporins to nuclear pore complexesQ28238651
The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear exportQ28254641
Nucleocytoplasmic transportQ28275907
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexesQ28277749
Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T CellsQ28615718
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interactionQ28616185
Identification of a signal for rapid export of proteins from the nucleusQ29547742
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
Nucleocytoplasmic transport: signals, mechanisms and regulationQ29547904
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleusQ29616325
The GTP-binding protein Ran/TC4 is required for protein import into the nucleusQ29620192
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factorQ29620193
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factorsQ29620194
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
Purification of a Ran-interacting protein that is required for protein import into the nucleusQ29620570
The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K proteinQ33886877
Protein export from the nucleus requires the GTPase Ran and GTP hydrolysisQ34321978
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasmQ34838735
Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrateQ35691655
A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.Q36237387
Nucleocytoplasmic recycling of the nuclear localization signal receptor alpha subunit in vivo is dependent on a nuclear export signal, energy, and RCC1Q36273838
Subnuclear trafficking of glucocorticoid receptors in vitro: chromatin recycling and nuclear exportQ36274092
Export of mRNA from microinjected nuclei of Xenopus laevis oocytesQ36531559
Analysis of Ran/TC4 function in nuclear protein importQ38300230
RNA exportQ40400161
Nuclear export signals and the fast track to the cytoplasmQ40459787
Mechanisms of nuclear protein import.Q40475438
Signal transmission between the plasma membrane and nucleus of T lymphocytesQ40642986
P433issue4
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)863-874
P577publication date1998-05-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleNucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro
P478volume141

Reverse relations

cites work (P2860)
Q40815624A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
Q30454343A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.
Q40906046A leptomycin B-sensitive homologue of human CRM1 promotes nuclear export of nuclear export sequence-containing proteins in Drosophila cells
Q22009935A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1
Q24682010A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export
Q28613530A second calcineurin binding site on the NFAT regulatory domain
Q34357759Activation of NFATc1 is directly mediated by IP3 in adult cardiac myocytes
Q30445593Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro
Q38760582Adenovirus core protein pVII is translocated into the nucleus by multiple import receptor pathways
Q38211443Allosteric control of the exportin CRM1 unraveled by crystal structure analysis
Q24682405CRM1-mediated recycling of snurportin 1 to the cytoplasm
Q24540387CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis
Q35586564Ca2+/calcineurin signalling in cells of the immune system
Q61995636Calcineurin: From structure to function
Q36288304Calreticulin is essential for cardiac development
Q28140993Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
Q44572801Constitutively elevated nuclear export activity opposes Ca2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1.
Q38730315Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals
Q38302290Control of nuclear export of hnRNP A1.
Q41586026Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCδ.
Q35241590Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors
Q30308287DNA binding domains in diverse nuclear receptors function as nuclear export signals.
Q51997983Dosage-dependent transcriptional regulation by the calcineurin/NFAT signaling in developing myocardium transition.
Q27860926Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Q44948716Efficient NES-dependent protein nuclear export requires ongoing synthesis and export of mRNAs.
Q24554230Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1
Q36003768Genetic screening for regulators of Prz1, a transcriptional factor acting downstream of calcineurin in fission yeast
Q24554331HuR regulates p21 mRNA stabilization by UV light
Q24538841ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathway
Q39189621IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells
Q33647302Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.
Q24290171IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2
Q27710450Impact of the crystallization condition on importin-β conformation
Q40854575Impaired NFAT regulation and its role in a severe combined immunodeficiency
Q35109174Importazole, a small molecule inhibitor of the transport receptor importin-β
Q37661564Importins and exportins regulating allergic immune responses
Q39758813In vitro analysis of nuclear mRNA export using molecular beacons for target detection.
Q28215961In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap
Q37399416Increases in Retrograde Injury Signaling Complex-Related Transcripts in Central Axons following Injury
Q33855277Inhibition of CRM1-mediated nuclear export of transcription factors by leukemogenic NUP98 fusion proteins
Q44917430Inhibition of Orai1-mediated Ca(2+) entry is a key mechanism of the antiproliferative action of sirolimus in human arterial smooth muscle.
Q24554335Integration of calcium and cyclic AMP signaling pathways by 14-3-3
Q36315268Involvement of nuclear import and export factors in U8 box C/D snoRNP biogenesis
Q33917101Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure
Q33695055Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo
Q33906170Manipulating immune responses with immunosuppressive agents that target NFAT.
Q27023012Multifaceted roles of STIM proteins
Q34527028Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.
Q24674855NXT1 is necessary for the terminal step of Crm1-mediated nuclear export
Q28344408Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3
Q28505632Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice
Q43428742Nuclear export in plants. Use of geminivirus movement proteins for a cell-based export assay
Q55077285Nuclear factor of activated T cells and early growth response-1 cooperate to mediate tissue factor gene induction by vascular endothelial growth factor in endothelial cells.
Q39451343Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway
Q38939102Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214.
Q24299213Nuclear targeting of transforming growth factor-beta-activated Smad complexes
Q39604496Nuclear translocation and activation of the transcription factor NFAT is blocked by herpes simplex virus infection
Q35029558Nuclear transport kinetics in microarrays of nuclear envelope patches
Q38411212Nup214 is required for CRM1-dependent nuclear protein export in vivo
Q38363950Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle
Q36426572Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells.
Q37823682Phosphorylation meets nuclear import: a review
Q28140841Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro
Q40701095Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
Q26822052Ran-dependent nuclear export mediators: a structural perspective
Q73561184Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2
Q57378150Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis
Q33771763Regulated nuclear localization of stress-responsive factors: how the nuclear trafficking of protein kinases and transcription factors contributes to cell survival
Q27937992Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1.
Q37426782Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells.
Q31864530Regulation of nuclear import by light-induced activation of caged nuclear localization signal in living cells
Q36287472Regulation of phospholipase C-gamma2 networks in B lymphocytes
Q50703706Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres.
Q35182984Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes
Q24799019Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling
Q42129111Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1.
Q40931334Shuttling of CTP:Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(0) --> G(1) transition
Q34170925Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development.
Q24305124Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus
Q27931940Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p.
Q43559962Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.
Q26781513Structural Basis of Targeting the Exportin CRM1 in Cancer
Q27675679Structural basis for cooperativity of CRM1 export complex formation
Q36631203The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Q42057495The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export
Q44015757The immunosuppressor st1959, a 3,5-diaryl-s-triazole derivative, inhibits T cell activation by reducing NFAT nuclear residency
Q34986205The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p).
Q50734500The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy.
Q35025290Vitamin D receptor and retinoid X receptor interactions in motion
Q39454383c-Jun NH(2)-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1.

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