Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2

scientific article published on 01 March 2000

Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.275.12.8991
P698PubMed publication ID10722748

P2093author name stringS Lee
I Groulx
M E Bonicalzi
P2860cites workStructure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor functionQ22009393
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisQ22009936
A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathwayQ24309825
The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasmQ24315066
Inhibition of Transcription Elongation by the VHL Tumor Suppressor ProteinQ24336629
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and CQ24336712
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2Q24523680
Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor proteinQ24530637
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteinsQ24564802
A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasmQ24609182
RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153Q24644181
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
A protein that shuttles between the nucleus and the cytoplasm is an important mediator of RNA exportQ27931607
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1Q28139243
Cancer-susceptibility genes. Gatekeepers and caretakersQ28236512
Regulation of CFTR chloride channels by syntaxin and Munc18 isoformsQ28255553
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligaseQ28506124
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasmQ28646841
Identification of a signal for rapid export of proteins from the nucleusQ29547742
A short amino acid sequence able to specify nuclear locationQ29547781
Nucleocytoplasmic transport: signals, mechanisms and regulationQ29547904
Identification of the von Hippel-Lindau disease tumor suppressor geneQ29618644
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasmQ29618907
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
The GTP-binding protein Ran/TC4 is required for protein import into the nucleusQ29620192
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factorQ29620193
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factorsQ29620194
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.Q30454343
Protective function of von Hippel-Lindau protein against impaired protein processing in renal carcinoma cellsQ33868951
The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K proteinQ33886877
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.Q33888123
Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinomaQ34320299
The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawalQ34744818
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrixQ34748818
pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiationQ34753344
ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motifQ35194372
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activityQ35201819
A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor.Q36222472
Subnuclear trafficking of glucocorticoid receptors in vitro: chromatin recycling and nuclear exportQ36274092
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor geneQ37285776
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau proteinQ37286026
Reconstitution of HIV-1 rev nuclear export: independent requirements for nuclear import and exportQ37477637
Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell densityQ37701211
Analysis of Ran/TC4 function in nuclear protein importQ38300230
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6Q39576878
Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancerQ40580380
Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependentQ41011329
Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasmQ41271927
Tumour suppression by the human von Hippel-Lindau gene productQ41320477
Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitroQ41961089
Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activityQ42469993
MPF localization is controlled by nuclear exportQ42649263
Mutations of the VHL tumour suppressor gene in renal carcinomaQ42806703
Two-way trafficking with Ran.Q47721385
Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysisQ57378150
Transcription-Dependent and Transcription-Independent Nuclear Transport of hnRNP ProteinsQ67923124
Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissuesQ73227598
RNA movement between the nucleus and the cytoplasmQ73258077
Import and export of the nuclear protein import receptor transportin by a mechanism independent of GTP hydrolysisQ74033395
The VHL tumour-suppressor gene paradigmQ77572384
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)8991-9000
P577publication date2000-03-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleRan-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2
P478volume275

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cites work (P2860)
Q42201994Antitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor
Q36421050Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.
Q28576044Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death
Q43761437Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation.
Q40015100Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.
Q28220414Molecular basis of the VHL hereditary cancer syndrome
Q52551376Nuclear export of the glucocorticoid receptor is accelerated by cell fusion-dependent release of calreticulin.
Q28647626Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
Q34530199Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.
Q35047240Regulation of tumor suppressors by nuclear-cytoplasmic shuttling
Q28586399Regulation of ubiquitin ligase dynamics by the nucleolus
Q35564185The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing
Q41612038The von Hippel-Lindau Tumor Suppressor Protein Is Destabilized by Src: Implications for Tumor Angiogenesis and Progression
Q28203455The von Hippel-Lindau tumor suppressor gene
Q34132816The von Hippel-Lindau tumor suppressor protein
Q24676092Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import
Q51971299Von Hippel-Lindau disease.
Q24651660eEF1A is a novel component of the mammalian nuclear protein export machinery

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