Chronic diseases, inflammation, and spices: how are they linked?

scientific article published on 25 January 2018

Chronic diseases, inflammation, and spices: how are they linked? is …
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scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1100620968
P356DOI10.1186/S12967-018-1381-2
P932PMC publication ID5785894
P698PubMed publication ID29370858

P2093author name stringAjaikumar B Kunnumakkara
Bharat B Aggarwal
Sahdeo Prasad
Alok Chandra Bharti
Subash Chandra Gupta
Kishore Banik
Bethsebie L Sailo
Choudhary Harsha
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Thymol inhibits LPS-stimulated inflammatory response via down-regulation of NF-κB and MAPK signaling pathways in mouse mammary epithelial cellsQ85968887
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1,8-cineole (eucalyptol) ameliorates cerulein-induced acute pancreatitis via modulation of cytokines, oxidative stress and NF-κB activity in miceQ44557299
1,8-cineole (eucalyptol), a monoterpene oxide attenuates the colonic damage in rats on acute TNBS-colitisQ44798627
Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampusQ44906182
Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production.Q44997366
Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism.Q45181284
Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanismQ45210030
Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic ratsQ45359078
Thymol attenuates allergic airway inflammation in ovalbumin (OVA)-induced mouse asthma.Q45918350
Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma modelQ46119498
Effect of coriander seed (Coriandrum sativum L.) ethanol extract on insulin release from pancreatic beta cells in streptozotocin-induced diabetic ratsQ46251163
The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models.Q46351150
Quercetin attenuates high fructose feeding-induced atherosclerosis by suppressing inflammation and apoptosis via ROS-regulated PI3K/AKT signaling pathwayQ46450154
Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen induced arthritisQ46462283
Coriandrum sativum Suppresses Aβ42-Induced ROS Increases, Glial Cell Proliferation, and ERK ActivationQ46464559
Protective Effects of Diallyl Sulfide on Ovalbumin-Induced Pulmonary Inflammation of Allergic Asthma Mice by MicroRNA-144, -34a, and -34b/c-Modulated Nrf2 ActivationQ46626801
Effects of a herbal gel containing carvacrol and chalcones on alveolar bone resorption in rats on experimental periodontitis.Q46704192
Chemopreventive efficacy of menthol on carcinogen-induced cutaneous carcinoma through inhibition of inflammation and oxidative stress in miceQ46731109
Carvacrol inhibits atherosclerotic neointima formation by downregulating reactive oxygen species production in vascular smooth muscle cellsQ46743311
Antioxidative compounds from the outer scales of onionQ46747045
Anti-asthma potential of crocin and its effect on MAPK signaling pathway in a murine model of allergic airway diseaseQ46794247
Cinnamaldehyde potentially attenuates gestational hyperglycemia in rats through modulation of PPARγ, proinflammatory cytokines and oxidative stress.Q47889121
Curcumin-piperine mixtures in self-microemulsifying drug delivery system for ulcerative colitis therapyQ47932847
Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathwayQ48003227
Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal MacrophagesQ48079297
Antidepressant Effect of Thymoquinone in Animal Models of DepressionQ48216372
Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice.Q48382356
Diosgenin reorganises hyperglycaemia and distorted tissue lipid profile in high-fat diet-streptozotocin-induced diabetic ratsQ48403936
Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model.Q48482708
Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extractQ48520068
Curcumin ameliorates insulin signalling pathway in brain of Alzheimer's disease transgenic miceQ48599563
Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathwaysQ48628620
Antimicrobial and antioxidant properties of rosemary and sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oilsQ50069365
Anti-inflammatory and anti-ulcer activities of carvacrol, a monoterpene present in the essential oil of oregano.Q50505254
Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model.Q50545510
Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis.Q50568762
Analysis of aromatic and terpenic constituents of pepper extracts by capillary electrochromatography.Q50688495
Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma.Q50876282
Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma.Q50886793
Antioxidant and anti-inflammatory effects of quercetin in functional and morphological alterations in streptozotocin-induced diabetic rats.Q50961731
Macelignan attenuated allergic lung inflammation and airway hyper-responsiveness in murine experimental asthma.Q51020163
Capsaicin regulates the NF-κB pathway in salivary gland inflammation.Q51057189
Crocin reduces the inflammation response in rheumatoid arthritis.Q51067371
Curcumin attenuates lupus nephritis upon interaction with regulatory T cells in New Zealand Black/White mice.Q51294019
Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats.Q51321580
Chemical constituents and activities of the essential oil from Myristica fragrans against cigarette beetle Lasioderma serricorne.Q51407909
Rosmarinic acid inhibits inflammation and angiogenesis of hepatocellular carcinoma by suppression of NF-κB signaling in H22 tumor-bearing mice.Q51427073
Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice.Q51515944
Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation.Q51692786
The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice.Q51725084
Anti-Warburg effect of rosmarinic acid via miR-155 in colorectal carcinoma cells.Q51783151
Inhibition of Inflammatory Response by Crocin Attenuates Hemorrhagic Shock-Induced Organ Damages in Rats.Q52097033
Effects of linalool on inflammation, matrix accumulation and podocyte loss in kidney of streptozotocin-induced diabetic rats.Q52746871
An experimental evaluation of the anti-atherogenic potential of the plant, Piper betle, and its active constitutent, eugenol, in rats fed an atherogenic diet.Q53110704
Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation.Q53208095
[Inflammation promotes the development of colitis-associated colorectal cancer].Q53233416
Dietary cardamom inhibits the formation of azoxymethane-induced aberrant crypt foci in mice and reduces COX-2 and iNOS expression in the colon.Q53355347
Multitargeting by turmeric, the golden spice: From kitchen to clinicQ38034177
Multiple biological properties of macelignan and its pharmacological implicationsQ38084170
Spices: the savory and beneficial science of pungencyQ38100671
The Th17 pathway as a therapeutic target in rheumatoid arthritis and other autoimmune and inflammatory disorders.Q38101877
Piper nigrum and piperine: an update.Q38102658
Anti-inflammatory treatments for chronic diseases: a review.Q38123260
Inflammation in the context of oral cancerQ38126182
Antioxidant potential of spices and their active constituents.Q38159761
Inflammation, ageing and chronic diseaseQ38206878
Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseasesQ38211960
"Disease modifying nutricals" for multiple sclerosisQ38272836
Inflammation and cancer: till death tears them apartQ38485607
Tumor-Elicited Inflammation and Colorectal CancerQ38555673
Involvement of inflammation in Alzheimer's disease pathogenesis and therapeutic potential of anti-inflammatory agents.Q38569669
Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far.Q38625534
The Mechanism in Gastric Cancer Chemoprevention by AllicinQ38629806
Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor modelQ38718506
Protective role of sulphoraphane against vascular complications in diabetesQ38721709
Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways.Q38738046
Anti-inflammatory Potential of Quercetin-3-O-β-D-("2"-galloyl)-glucopyranoside and Quercetin Isolated from Diospyros kaki calyx via Suppression of MAP Signaling Molecules in LPS-induced RAW 264.7 Macrophages.Q38744744
Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitisQ38746403
PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microgliaQ38769452
Inflammatory microenvironment and human papillomavirus-induced carcinogenesis.Q38791845
Sesamin attenuates mast cell-mediated allergic responses by suppressing the activation of p38 and nuclear factor-κB.Q38819223
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease.Q38822745
Curcumin retunes cholesterol transport homeostasis and inflammation response in M1 macrophage to prevent atherosclerosisQ38827633
Antitumor Activity of Garcinol in Human Prostate Cancer Cells and Xenograft MiceQ38829911
OGT-mediated O-GlcNAcylation promotes NF-κB activation and inflammation in acute pancreatitisQ38832460
Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivationQ38832801
Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathwayQ38836690
Effect of Sesamin Supplementation on Glycemic Status, Inflammatory Markers, and Adiponectin Levels in Patients with Type 2 Diabetes Mellitus.Q38838499
6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activationQ38844522
Interleukins 1 and 6 as Main Mediators of Inflammation and Cancer.Q38853516
Interleukin-33 promotes inflammatory cytokine production in chronic airway inflammationQ38855027
Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approachQ30234740
Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivoQ30432272
Effects of diallyl disulfide (DADS) on expression of apoptosis associated proteins in androgen independent human prostate cancer cells (PC-3).Q33365062
Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid β(1-42) rat model of Alzheimer's diseaseQ33458938
Anti-inflammatory effect of cinnamaldehyde in Helicobacter pylori induced gastric inflammationQ33464331
Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathwayQ33565340
Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer developmentQ33594937
Cinnamon extract induces tumor cell death through inhibition of NFkappaB and AP1Q33639024
Phytochemicals, Antioxidant and Antiproliferative Properties of Rosmarinus officinalis L on U937 and CaCo-2 CellsQ33652242
Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substancesQ33750391
The Role of Type 2 Inflammation in the Pathogenesis of Asthma ExacerbationsQ33786076
Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease.Q33823673
Coriander alleviates 2,4-dinitrochlorobenzene-induced contact dermatitis-like skin lesions in miceQ34019361
Value addition in sesame: A perspective on bioactive components for enhancing utility and profitabilityQ34024267
Reducing effect of curcumin on expressions of TNF-alpha, IL-6 and IL-8 in rats with chronic nonbacterial prostatitisQ34100342
Inflammation 2010: new adventures of an old flameQ34105595
Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathwayQ34254130
Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherolsQ34308705
Mechanistic links between COPD and lung cancerQ34331434
Comparative analysis of the oil and supercritical CO2 extract of Elettaria cardamomum (L.) Maton.Q34353861
High-dose diosgenin reduces bone loss in ovariectomized rats via attenuation of the RANKL/OPG ratioQ34358535
Epigenetic modulation in the treatment of atherosclerotic diseaseQ34413965
Differentiation therapy: sesamin as an effective agent in targeting cancer stem-like side population cells of human gallbladder carcinomaQ34467897
Culinary herbs and spices: their bioactive properties, the contribution of polyphenols and the challenges in deducing their true health benefitsQ34487053
Gas chromatography/mass spectrometry analysis of Laurus nobilis essential oil composition of northern CyprusQ34586488
Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetesQ34660346
Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cellsQ34670989
D-Limonene: safety and clinical applications.Q34723942
Anti-atherosclerotic and anti-inflammatory actions of sesame oil.Q34802660
Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapyQ34876505
Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulationQ35065451
6-gingerol protects against nutritional steatohepatitis by regulating key genes related to inflammation and lipid metabolismQ35131341
Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancerQ35155622
Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre miceQ35479026
Garcinol inhibits tumour cell proliferation, angiogenesis, cell cycle progression and induces apoptosis via NF-κB inhibition in oral cancer.Q38862175
Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate modelQ38867044
Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cellsQ38890631
Chemical variation among indigenous populations of Foeniculum vulgare var. vulgare in IsraelQ38892572
Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW480 and HT-29 Cells via Downregulating the Mitogen-Activated Protein Kinase Pathways.Q38932478
Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells.Q38936905
The therapeutic efficacy of α-pinene in an experimental mouse model of allergic rhinitisQ38954482
Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathwayQ38954969
Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cellsQ38955329
Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.Q38957154
Phenolic profile, antioxidant capacity and anti-inflammatory activity of Anethum graveolens L. essential oil.Q38963117
Garcinol and Its Role in Chronic DiseasesQ38965241
Garcinol, an acetyltransferase inhibitor, suppresses proliferation of breast cancer cell line MCF-7 promoted by 17β-estradiolQ38977688
Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in miceQ38978368
Capsaicin and Its Role in Chronic Diseases.Q38988562
Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cellsQ39009023
Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease.Q39012955
Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activityQ39013173
Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo.Q39017898
Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancerQ39023287
Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic painQ39066575
A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer's DiseaseQ39093455
Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppressionQ39094006
Susceptibility to chronic inflammation: an updateQ39107170
Screening of flavonoid "quercetin" from the rhizome of Smilax china Linn. for anti-psoriatic activityQ39169013
Anti-cancer effects of Piper nigrum via inducing multiple molecular signaling in vivo and in vitroQ39172973
L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmittersQ39189846
Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells.Q39227845
Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthmaQ39234841
Role of menthol in treatment of candidial napkin dermatitisQ39273622
Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cellsQ39326014
Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-κB, C/EBP and AP-1 signaling pathways in murine macrophagesQ39357191
Anethole suppressed cell survival and induced apoptosis in human breast cancer cells independent of estrogen receptor statusQ39371720
Rosmarinic acid potentiates ATRA-induced macrophage differentiation in acute promyelocytic leukemia NB4 cells.Q35497190
Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cellsQ35653619
Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer's DiseaseQ35671697
Rosmarinic acid and arbutin suppress osteoclast differentiation by inhibiting superoxide and NFATc1 downregulation in RAW 264.7 cellsQ35803432
Quercetin Suppresses Twist to Induce Apoptosis in MCF-7 Breast Cancer CellsQ35817167
Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1Q35822864
The effects of 6-gingerol on proliferation, differentiation, and maturation of osteoblast-like MG-63 cellsQ35881352
Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancerQ35896471
Cancer treatment-related neuropathic pain: proof of concept study with menthol--a TRPM8 agonistQ35901628
Age-associated chronic diseases require age-old medicine: role of chronic inflammationQ35923150
Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cellsQ35954718
Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulationQ35995435
Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitroQ36001464
Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasiaQ36031004
Zingiber officinale attenuates retinal microvascular changes in diabetic rats via anti-inflammatory and antiangiogenic mechanismsQ36049918
Coriandrum sativum L. seed extract mitigates lipotoxicity in RAW 264.7 cells and prevents atherogenic changes in rats.Q36051391
Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD miceQ36117539
Review of Pharmacological Properties and Chemical Constituents of Pimpinella anisumQ36118926
Curcumin ameliorates alveolar epithelial injury in a rat model of chronic obstructive pulmonary diseaseQ36124519
Diosgenin‑induced autophagy and apoptosis in a human prostate cancer cell lineQ36144326
Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation.Q36190775
Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in ratsQ36363633
Rosmarinic Acid Alleviates Neurological Symptoms in the G93A-SOD1 Transgenic Mouse Model of Amyotrophic Lateral SclerosisQ36396423
Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIsQ36403945
Therapeutic roles of curcumin: lessons learned from clinical trialsQ36502400
COPD and squamous cell lung cancer: aberrant inflammation and immunity is the common link.Q36546997
Inflammation and cancer: how hot is the link?Q36556766
Anti-oncogenic perspectives of spices/herbs: A comprehensive reviewQ36785236
Cancer cell signaling pathways targeted by spice-derived nutraceuticalsQ36819371
Synergistic interaction of benign prostatic hyperplasia and prostatitis on prostate cancer riskQ36857502
Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitusQ36914125
Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in MiceQ36936731
Effect of carvacrol on various cytokines genes expression in splenocytes of asthmatic miceQ36953178
Menthol inhibits the proliferation and motility of prostate cancer DU145 cellsQ39375869
Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cellsQ39469882
Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophagesQ39527801
The Roman and Islamic spice trade: New archaeological evidenceQ39549470
[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense systemQ39577488
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCα/ERK1/2-dependent matrix metalloproteinase-9 expression.Q39585514
Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivoQ39630830
Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cellsQ39682412
Ameliorative effect of thymoquinone on ovalbumin-induced allergic conjunctivitis in Balb/c miceQ39747429
HAT inhibitor, garcinol, exacerbates lipopolysaccharide‑induced inflammation in vitro and in vivoQ39815745
Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1betaQ39969055
Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis.Q39970049
In vitro and in vivo anthelmintic activity of seed extract of Coriandrum sativum compared to Niclosamid against Hymenolepis nana infection.Q40439599
Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infectionQ40495389
Rosmarinic acid inhibits poly(I:C)-induced inflammatory reaction of epidermal keratinocytesQ40742312
Allicin Alleviates Dextran Sodium Sulfate- (DSS-) Induced Ulcerative Colitis in BALB/c Mice.Q40813046
Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling.Q40891623
Anti-Inflammatory Effects of Capsaicin and Piperine on Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils.Q41125099
Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancerQ41195198
Diosgenin inhibits IL-1β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes.Q41643403
Allicin attenuates inflammation and suppresses HLA-B27 protein expression in ankylosing spondylitis miceQ42041341
An overview on saffron, phytochemicals, and medicinal propertiesQ42134060
Effect of Coriandrum sativum hydroalcoholic extract and its essential oil on acetic acid- induced acute colitis in ratsQ42151304
The effect of carvacrol on systemic inflammation in guinea pigs model of COPD induced by cigarette smoke exposureQ42181199
Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR MiceQ42277214
The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant responseQ42405785
Modifying effect of diallyl sulfide on colon carcinogenesis in C57BL/6J-ApcMin/⁺ miceQ42509643
Gastroprotective effects of thymol on acute and chronic ulcers in rats: The role of prostaglandins, ATP-sensitive K(+) channels, and gastric mucus secretion.Q42699900
Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virusQ42746520
Eugenol restricts DMBA croton oil induced skin carcinogenesis in mice: downregulation of c-Myc and H-ras, and activation of p53 dependent apoptotic pathwayQ43033402
Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alphaQ43077705
Eugenol precludes cutaneous chemical carcinogenesis in mouse by preventing oxidative stress and inflammation and by inducing apoptosisQ43204344
Eugenol inhibits cell proliferation via NF-κB suppression in a rat model of gastric carcinogenesis induced by MNNG.Q43256204
Chemical composition, antimicrobial property and microencapsulation of Mustard (Sinapis alba) seed essential oil by complex coacervation.Q53498109
Carvacrol exhibits anti-oxidant and anti-inflammatory effects against 1, 2-dimethyl hydrazine plus dextran sodium sulfate induced inflammation associated carcinogenicity in the colon of Fischer 344 rats.Q53542098
Curcumin ameliorates asthmatic airway inflammation by activating nuclear factor-E2-related factor 2/haem oxygenase (HO)-1 signalling pathway.Q53589405
Rosmarinic Acid Attenuates Sodium Taurocholate-Induced Acute Pancreatitis in Rats by Inhibiting Nuclear Factor-κB Activation.Q53671825
Effects of crocin on experimental obesity and type-2 diabetes.Q53757753
Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats.Q53837221
Thymoquinone Inhibits IL-1β-Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF-κB and MAPKs Signaling Pathway.Q54260446
Protective effects of alpha-pinene in mice with cerulein-induced acute pancreatitis.Q54291992
Garcinol suppresses inflammation-associated colon carcinogenesis in mice.Q54341114
Anti-inflammatory and chondroprotective activity of (+)-α-pinene: structural and enantiomeric selectivity.Q54382605
Eugenol ameliorates hepatic steatosis and fibrosis by down-regulating SREBP1 gene expression via AMPK-mTOR-p70S6K signaling pathway.Q55072299
Oral administration of d-Limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humansQ57417851
Quercetin Inhibits Inflammatory Bone Resorption in a Mouse Periodontitis ModelQ60348183
Compartive study of volatile components and fatty acids of plants and in vitro cultures of parsley (Petroselinum crispum (Mill) nym ex hill)Q73159416
Risk factors for metformin-associated lactic acidosisQ73166964
Changes in phytochemical and antioxidant activity of selected pepper cultivars (Capsicum species) as influenced by maturityQ73811820
Antiinflammatory effects of euclyptol (1.8-cineole) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes ex vivoQ77299831
Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifoliaQ79805324
Chemical composition and antioxidant properties of clove leaf essential oilQ80117413
Composition of the essential oil of Salvia officinalis L. from various European countriesQ80287695
Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat modelsQ80464749
Comparison of distillation and ultrasound-assisted extraction methods for the isolation of sensitive aroma compounds from garlic (Allium sativum)Q81348974
A new therapeutic candidate for oral aphthous ulcer: AllicinQ81930918
The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in ratsQ83075280
D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesisQ83408816
Clove and eugenol in noncytotoxic concentrations exert immunomodulatory/anti-inflammatory action on cytokine production by murine macrophagesQ83659511
[Role of NF-κB in the anti-tumor effect of thymoquinone on bladder cancer]Q83851236
Limonene inhalation reduces allergic airway inflammation in Dermatophagoides farinae-treated miceQ84077095
Inflammation, a silent killer in cancer is not so silent!Q84387243
Effects of diallyl sulphide in chondrocyte and cartilage in experimental osteoarthritis in rabbitQ84655717
IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritisQ84972123
Astragalin Attenuates Allergic Inflammation in a Murine Asthma ModelQ85344668
Chemopreventive Effect of Cardamom (Elettaria cardamomum L.) Against Benzo(α)Pyrene-Induced Forestomach Papillomagenesis in Swiss Albino MiceQ85390290
Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXRαQ85412274
Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis.Q36978209
Potential of spice-derived phytochemicals for cancer prevention.Q37211052
Effect of Laurus nobilis L. Essential Oil and its Main Components on α-glucosidase and Reactive Oxygen Species Scavenging ActivityQ37268476
Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cellsQ37330990
Gamma-tocopherol attenuates moderate but not severe colitis and suppresses moderate colitis-promoted colon tumorigenesis in miceQ37384881
Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancerQ37444253
In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell linesQ37668468
Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathwayQ37696365
Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse modelQ37718435
Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation.Q37739694
Thymol mitigates lipopolysaccharide-induced endometritis by regulating the TLR4- and ROS-mediated NF-κB signaling pathwaysQ37746228
Cinnamon and healthQ37798207
Inflammation in COPD: pathogenesis, local and systemic effectsQ37855590
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectchronic conditionQ383126
P304page(s)14
P577publication date2018-01-25
P1433published inJournal of Translational MedicineQ15716664
P1476titleChronic diseases, inflammation, and spices: how are they linked?
P478volume16