Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies

scientific article published on 13 February 2018

Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.TIM.2018.01.008
P932PMC publication ID6054543
P698PubMed publication ID29452952

P50authorAimee TanQ56441634
Lauren O BakaletzQ78772868
Kate L SeibQ42328606
P2093author name stringMichael P Jennings
John M Atack
P2860cites workEpigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signalsQ22122053
The methylomes of six bacteriaQ24598577
Entering the era of bacterial epigenomics with single molecule real time DNA sequencingQ24629701
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islandsQ24631957
Epigenetic gene regulation in the bacterial worldQ24669987
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genesQ24684053
The other face of restriction: modification-dependent enzymesQ26851498
The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine DevelopmentQ28074750
The Epigenomic Landscape of ProkaryotesQ28550136
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cellsQ29618090
Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycleQ30437973
Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencingQ30470204
The complex methylome of the human gastric pathogen Helicobacter pyloriQ30572851
A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzaeQ30659946
Phasevarions mediate random switching of gene expression in pathogenic NeisseriaQ33434451
Complete Genome Sequence of Moraxella catarrhalis Strain CCRI-195ME, Isolated from the Middle Ear.Q33815343
Type II restriction endonucleases--a historical perspective and moreQ33843093
Direct detection of DNA methylation during single-molecule, real-time sequencingQ33888756
Regulation of pap pilin phase variation by a mechanism involving differential dam methylation statesQ33923349
The phasevarion: a genetic system controlling coordinated, random switching of expression of multiple genesQ33936713
Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptoglobin binding protein genes of Haemophilus influenzaeQ33993033
The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genesQ34097495
Phasevarion mediated epigenetic gene regulation in Helicobacter pyloriQ34097569
DNA methylome analysis using short bisulfite sequencing dataQ34145204
Complex restriction enzymes: NTP-driven molecular motorsQ34178514
Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzaeQ34211653
A random six-phase switch regulates pneumococcal virulence via global epigenetic changesQ34310334
Type III restriction-modification enzymes: a historical perspectiveQ34358103
ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media.Q34436584
Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis.Q34470436
Discrimination of N6-methyl adenine in a specific DNA sequence.Q43066997
REBASE--a database for DNA restriction and modification: enzymes, genes and genomesQ43214917
Characterization of the NgoAXP: phase-variable type III restriction-modification system in Neisseria gonorrhoeae.Q43275825
A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44.Q44462970
Phase variable restriction-modification systems in Moraxella catarrhalisQ45183866
Mapping DNA methylation with high-throughput nanopore sequencingQ46338910
Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pyloriQ47132342
Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingaeQ47744169
The role of Dam methylation in phase variation of Haemophilus influenzae genes involved in defence against phage infectionQ81317030
Real-time DNA sequencing from single polymerase moleculesQ84483467
Comparative genomics of the restriction-modification systems in Helicobacter pyloriQ34489772
Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168Q34509855
Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.Q34513606
ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis MediaQ34530528
The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human NeutrophilsQ34557738
Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression.Q34659322
Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients.Q35109107
Deletion of one nucleotide within the homonucleotide tract present in the hsdS gene alters the DNA sequence specificity of type I restriction-modification system NgoAVQ35598777
Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomesQ35813616
Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzaeQ35965177
Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae.Q36079875
Detecting DNA cytosine methylation using nanopore sequencing.Q36285424
Functional analysis of the M.HpyAIV DNA methyltransferase of Helicobacter pyloriQ36314651
Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone.Q36318953
Type III Methyltransferase M.NgoAX from Neisseria gonorrhoeae FA1090 Regulates Biofilm Formation and Interactions with Human CellsQ36387438
Bacterial contingency loci: the role of simple sequence DNA repeats in bacterial adaptationQ36649037
The restriction-modification system of Pasteurella haemolytica is a member of a new family of type I enzymesQ36832889
An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suisQ37067613
Analysis of nontypeable haemophilus influenzae phase-variable genes during experimental human nasopharyngeal colonizationQ37070358
Epigenetics: definition, mechanisms and clinical perspective.Q37469995
ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12Q37589808
Restriction-modification systems may be associated with Helicobacter pylori virulence.Q37768496
Mechanistic insights into type III restriction enzymesQ37971558
Diverse functions of restriction-modification systems in addition to cellular defenseQ38087543
Programmed heterogeneity: epigenetic mechanisms in bacteriaQ38099632
Type I restriction enzymes and their relatives.Q38143721
The modA10 phasevarion of nontypeable Haemophilus influenzae R2866 regulates multiple virulence-associated traits.Q38663969
Distribution of Type I Restriction-Modification Systems in Streptococcus suis: An OutlookQ38792757
DNA methyltransferases and epigenetic regulation in bacteriaQ38913885
Phase-variable restriction/modification systems are required for Helicobacter pylori colonizationQ39107218
HmbR, a hemoglobin-binding outer membrane protein of Neisseria meningitidis, undergoes phase variationQ39494891
Phase-variable methylation and epigenetic regulation by type I restriction-modification systemsQ40075220
P433issue8
P304page(s)715-726
P577publication date2018-02-13
P1433published inTrends in MicrobiologyQ15265732
P1476titlePhasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies
P478volume26

Reverse relations

cites work (P2860)
Q61293489Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease
Q58085053Comparative genomic and methylome analysis of non-virulent D74 and virulent Nagasaki Haemophilus parasuis isolates
Q57026874DNA phosphorothioate modification - a new multi-functional epigenetic system in bacteria
Q90463939Deciphering bacterial epigenomes using modern sequencing technologies
Q58697525Formation of phenotypic lineages in Salmonella enterica by a pleiotropic fimbrial switch
Q60912656High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae
Q58596564Moraxella catarrhalis Restriction-Modification Systems are Associated with Phylogenetic Lineage and Disease
Q91106221Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions
Q57285690Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution
Q98158317Systematic Analysis of REBASE Identifies Numerous Type I Restriction-Modification Systems with Duplicated, Distinct hsdS Specificity Genes That Can Switch System Specificity by Recombination
Q59651655The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans
Q91819134The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media
Q91287194The bacterial epigenome
Q92000659Transcriptome Sequencing Data Sets for Determining Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae Strains Isolated from Patients with Chronic Obstructive Pulmonary Disease
Q92358717Transcriptome analyses of cells carrying the Type II Csp231I restriction-modification system reveal cross-talk between two unrelated transcription factors: C protein and the Rac prophage repressor
Q92550311Understanding the emergence of bacterial pathogens in novel hosts

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