Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells

scientific article published on 01 June 1994

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/01.RES.74.6.1141
P698PubMed publication ID8187280

P50authorKathy K. GriendlingQ52725890
P2093author name stringR W Alexander
C A Minieri
J D Ollerenshaw
P433issue6
P304page(s)1141-1148
P577publication date1994-06-01
P1433published inCirculation ResearchQ2599020
P1476titleAngiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
P478volume74

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Q39767111Homocysteine-induced oxidative stress upregulates chymase in mouse mastocytoma cells
Q77725793Hydralazine prevents endothelial dysfunction, but not the increase in superoxide production in nitric oxide-deficient hypertension
Q37359995Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug
Q36314716Hyperoxaluria-induced oxidative stress and antioxidants for renal protection
Q35210556Hypertension and other morbidities with Cushing's syndrome associated with corticosteroids: a review
Q37827620Hypertension in diabetic nephropathy: epidemiology, mechanisms, and management
Q34028155Hypertensive vascular disease and inflammation: mechanical and humoral mechanisms
Q36326008Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion
Q35021833Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms
Q44960480Identification of a biologically active component in minimally oxidized low density lipoprotein (MM-LDL) responsible for aortic smooth muscle cell proliferation
Q43263111Iloprost inhibits superoxide formation and gp91phox expression induced by the thromboxane A2 analogue U46619, 8-isoprostane F2alpha, prostaglandin F2alpha, cytokines and endotoxin in the pig pulmonary artery
Q42873285Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm
Q35364697Impaired glutathione redox system paradoxically suppresses angiotensin II-induced vascular remodeling
Q34426146Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene
Q36421164Important aspects of urine sampling for angiotensinogen measurement: time and preservation conditions in healthy individuals
Q73288879Improved endothelial function with angiotensin-converting enzyme inhibitors
Q64069141Improvement in Diabetic Retinopathy through Protection against Retinal Apoptosis in Spontaneously Diabetic Torii Rats Mediated by Ethanol Extract of C.K. Schneid
Q92823526In Vitro and In Vivo Antioxidant Properties of Taraxacum officinale in Nω-Nitro-l-Arginine Methyl Ester (L-NAME)-Induced Hypertensive Rats
Q73515085In human hypercholesterolemia increased reactivity of vascular smooth muscle cells is due to altered subcellular Ca(2+) distribution
Q44589042Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment
Q33527029Increased expression of endothelin ET(B) and angiotensin AT(1) receptors in peripheral resistance arteries of patients with suspected acute coronary syndrome
Q80001226Increased superoxide anion production is associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit model
Q34489884Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose
Q36956379Inflammation and endothelial dysfunction during aging: role of NF-kappaB
Q35613484Influence of obesity and metabolic dysfunction on the endothelial control in the coronary circulation
Q36949963Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury
Q28569170Inhibition of NADPH-cytochrome P450 reductase and glyceryl trinitrate biotransformation by diphenyleneiodonium sulfate
Q35013600Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney
Q37422104Inhibition of biliverdin reductase increases ANG II-dependent superoxide levels in cultured renal tubular epithelial cells
Q37406883Inhibition of the renin-angiotensin system and target organ protection
Q35416745Insulin reverses D-glucose-increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells
Q57787242Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation
Q34724693Intestinal NADPH oxidase 2 activity increases in a neonatal rat model of necrotizing enterocolitis.
Q41491665Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries
Q42120155Involvement of H2O2 in superoxide-dismutase-induced enhancement of endothelium-dependent relaxation in rabbit mesenteric resistance artery
Q41962924Involvement of an NAD(P)H oxidase-like enzyme in superoxide anion and hydrogen peroxide generation by rat type II cells
Q36091351Involvement of the intrarenal renin-angiotensin system in experimental models of glomerulonephritis
Q35056901Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases
Q35047383Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1.
Q32054951Irbesartan, an angiotensin type 1 receptor inhibitor, regulates markers of inflammation in patients with premature atherosclerosis
Q43796478Irbesartan, an angiotensin type 1 receptor inhibitor, regulates the vascular oxidative state in patients with coronary artery disease
Q41603069Is there a rationale for combining angiotensin-converting enzyme inhibitors and calcium antagonists in cardiovascular disease?
Q37344438Kallikrein-modified mesenchymal stem cell implantation provides enhanced protection against acute ischemic kidney injury by inhibiting apoptosis and inflammation
Q34357797Kallistatin attenuates endothelial apoptosis through inhibition of oxidative stress and activation of Akt-eNOS signaling
Q36029511Kallistatin inhibits TGF-β-induced endothelial-mesenchymal transition by differential regulation of microRNA-21 and eNOS expression
Q36023483Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice.
Q44472433Lessons learned from experimental myocarditis
Q35101890Lipid raft redox signaling: molecular mechanisms in health and disease
Q35126614Lipopolysaccharide (LPS)-mediated angiopoietin-2-dependent autocrine angiogenesis is regulated by NADPH oxidase 2 (Nox2) in human pulmonary microvascular endothelial cells
Q95380074Lisinopril inhibits endothelin-1 in the early period of hepatic reperfusion injury in a partial hepatectomy model
Q37828412Local bone marrow Renin-Angiotensin system and atherosclerosis
Q42670850Localization of NADPH oxidase in sympathetic and sensory ganglion neurons and perivascular nerve fibers
Q36821496Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: enhancement by angiotensin II
Q36909397Long-term trandolapril treatment is associated with reduced aortic stiffness: the prevention of events with angiotensin-converting enzyme inhibition hemodynamic substudy
Q84963903Losartan abolishes oxidative stress induced by intermittent hypoxia in humans
Q43166520Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats
Q37250956Losartan improves impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type 1 diabetic rats
Q42509129Loss of Smooth Muscle α-Actin Leads to NF-κB-Dependent Increased Sensitivity to Angiotensin II in Smooth Muscle Cells and Aortic Enlargement.
Q35177092Loss of angiotensin II receptor expression in dopamine neurons in Parkinson's disease correlates with pathological progression and is accompanied by increases in Nox4- and 8-OH guanosine-related nucleic acid oxidation and caspase-3 activation
Q34473866Low mercury concentration produces vasoconstriction, decreases nitric oxide bioavailability and increases oxidative stress in rat conductance artery.
Q36968881Low-dose angiotensin II infusion restores vascular function in cerebral arteries of high salt-fed rats by increasing copper/zinc superoxide dimutase expression
Q41922173Lung injury and oxidoreductases
Q36162737Luteolin Ameliorates Hypertensive Vascular Remodeling through Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells
Q32062986Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells
Q40347239Lysophosphatidylcholine-induced elevation of asymmetric dimethylarginine level by the NADPH oxidase pathway in endothelial cells.
Q46423522Macrophages come to mind as keys to cognitive decline
Q38965333Macrophages in neuroinflammation: role of the renin-angiotensin-system.
Q37730653Management of cardiorenal metabolic syndrome in diabetes mellitus: a phytotherapeutic perspective
Q91801597Maternal high-sodium intake affects the offspring' vascular renin-angiotensin system promoting endothelial dysfunction in rats
Q34764783Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stress
Q44037751Measuring reactive oxygen species inhibition of endothelin-converting enzyme
Q74595353Mechanism by which quinapril improves vascular function in coronary artery disease
Q40269875Mechanisms of potentiation of Angiotensin II-induced contractile response of isolated rat aorta by hydrogen peroxide and tert-butyryl hydroperoxide
Q37062099Mechanisms of radiation-induced brain toxicity and implications for future clinical trials
Q33934937Mediation of tubuloglomerular feedback by adenosine: evidence from mice lacking adenosine 1 receptors
Q37118254Membrane raft redox signalosomes in endothelial cells
Q35031623Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.
Q36093354Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms
Q34442434Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose
Q36938178Microarray gene expression profiling reveals antioxidant-like effects of angiotensin II inhibition in atherosclerosis
Q39169210Microvascular NADPH oxidase in health and disease.
Q34600173Mitochondria as signaling organelles in the vascular endothelium
Q38268844Mitochondria: a pathogenic paradigm in hypertensive renal disease
Q43116432Mitochondrial dysfunction and mitochondrial-produced reactive oxygen species: new targets for neurogenic hypertension?
Q38266758Mitochondrial injury and dysfunction in hypertension-induced cardiac damage
Q46432453Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium.
Q44022921Mitochondrial superoxide production during oxalate-mediated oxidative stress in renal epithelial cells
Q35178446Modulating atherosclerosis through inhibition or blockade of angiotensin
Q34541203Modulation of redox signaling promotes apoptosis in epithelial ovarian cancer cells
Q40895409Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice
Q28070313Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models
Q33807091Molecular Signals Elicited by GPCR Agonists in Hypertension, Cardiovascular Remodeling: Are MMPs and ADAMs Elusive Therapeutic Targets?
Q44574646Multiple actions of angiotensin II in hypertension: benefits of AT1 receptor blockade
Q74106093Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells
Q28300003Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix
Q44417520NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells
Q33593365NAD(P)H oxidases in coronary artery disease.
Q63365800NADH/NADPH Oxidase and Vascular Function
Q35115451NADPH Oxidase in Endothelial Cells: Impact on Atherosclerosis
Q42588680NADPH oxidase 4 mediates TGF-β-induced smooth muscle α-actin via p38MAPK and serum response factor
Q73303463NADPH oxidase activity is required for endothelial cell proliferation and migration
Q44939750NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius.
Q37138926NADPH oxidase contributes to coronary endothelial dysfunction in the failing heart
Q28571522NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells
Q34766266NADPH oxidase(s): new source(s) of reactive oxygen species in the vascular system?
Q36001842NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells
Q34054215NADPH oxidase: a universal oxygen sensor?
Q37342232NADPH oxidases and angiotensin II receptor signaling
Q90576094NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Q27001094NADPH oxidases in heart failure: poachers or gamekeepers?
Q33632089NADPH oxidases in vascular pathology
Q36302873NADPH oxidases: an overview from structure to innate immunity-associated pathologies
Q39988593NADPH oxidases: molecular understanding finally reaching the clinical level?
Q31148000NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide.
Q28295706NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection
Q42701348NOX and inflammation in the vascular adventitia
Q40133141NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation.
Q50126148Natriuretic peptide receptor-C activation attenuates angiotensin II-induced enhanced oxidative stress and hyperproliferation of aortic vascular smooth muscle cells.
Q30940745Negative feedback regulation of reactive oxygen species on AT1 receptor gene expression
Q37965160Neural degeneration in the retina of the streptozotocin-induced type 1 diabetes model
Q35116071Neuronal and non-neuronal modulation of sympathetic neurovascular transmission
Q37718340New antiarrhythmic drugs for treatment of atrial fibrillation.
Q40991742New insights into mechanisms underlying nitrate tolerance
Q90989969Newly manufactured Marukome MK-34-1 miso with angiotensin-converting enzyme inhibitory activity and its antihypertensive effects in genetic hypertensive rat models
Q60077919News and Views
Q39024659Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma
Q35583191Nitrate tolerance and the links with endothelial dysfunction and oxidative stress
Q38605600Nitric oxide and cardiovascular risk factors.
Q37034771Nitric oxide generation by the organic nitrate NDBP attenuates oxidative stress and angiotensin II-mediated hypertension
Q73807241Nitric oxide in heart failure
Q30486865Nitric oxide synthase-dependent responses of the basilar artery during acute infusion of nicotine
Q44612476Nitrosonifedipine ameliorates angiotensin II-induced vascular remodeling via antioxidative effects
Q35551180Noncholesterol-Lowering Effects of Statins
Q35004286Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance.
Q37346056Norepinephrine increases NADPH oxidase-derived superoxide in human peripheral blood mononuclear cells via α-adrenergic receptors
Q90744103Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity and Cardiovascular Diseases
Q34069745Novel homologs of gp91phox.
Q28483560Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy
Q36168729Novel sandwich ELISA for human angiotensinogen
Q37392163Nox proteins in signal transduction
Q37139048Nox4 NADPH oxidase mediates oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cells
Q35896207Nox4 oxidase overexpression specifically decreases endogenous Nox4 mRNA and inhibits angiotensin II-induced adventitial myofibroblast migration
Q36411174O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase
Q46738694Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury.
Q37679126Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells
Q37430733Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells
Q33743649Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load
Q34107235Oxidant stress in the vasculature
Q41260199Oxidants as stimulators of signal transduction
Q28393242Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling
Q30080036Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Q42776854Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II.
Q35760065Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: implications for angiotensin II-induced vascular dysfunction
Q37867946Oxidative stress and endothelial dysfunction in hypertension
Q82623891Oxidative stress and enhanced sympathetic vasoconstriction in contracting muscles of nitrate-tolerant rats and humans
Q34038044Oxidative stress and metabolic pathologies: from an adipocentric point of view.
Q38228080Oxidative stress and organ damages
Q36015440Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases
Q37738027Oxidative stress and vascular function: implications for pharmacologic treatments
Q33818137Oxidative stress and vascular smooth muscle cell growth: a mechanistic linkage by cyclophilin A
Q46464910Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia
Q46842368Oxidative stress contributes to renovascular hypertension.
Q92184944Oxidative stress contributes to vascular calcification in patients with chronic kidney disease
Q42589408Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK.
Q35087692Oxidative stress in diabetic nephropathy: basic and clinical information
Q37820092Oxidative stress in early diabetic nephropathy: fueling the fire
Q37900100Oxidative stress in heart failure: what are we missing?
Q48415409Oxidative stress in the brain and arterial hypertension.
Q46116463Oxidative stress in the sympathetic premotor neurons contributes to sympathetic activation in renovascular hypertension.
Q34456692Oxidative stress markers in Korean subjects with insulin resistance syndrome
Q44258753Oxidative stress, NO* and smooth muscle cell extracellular superoxide dismutase expression
Q43086910Oxidative stress, the capo of endothelial dysfunction in chronic renovascular hypertension.
Q38213038Oxidative stress: A cause and therapeutic target of diabetic complications
Q43081749Oxidative stress: Predictive marker for coronary artery disease
Q41750986Oxygen radicals and signaling
Q37016695Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells
Q35403487PPARγ ligands regulate NADPH oxidase, eNOS, and barrier function in the lung following chronic alcohol ingestion
Q35639923PPARδ coordinates angiotensin II-induced senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation
Q38165049Pathogenesis of chronic cardiorenal syndrome: is there a role for oxidative stress?
Q57296797Pathophysiological Alterations of Redox Signaling and Endocannabinoid System in Granulocytes and Plasma of Psoriatic Patients
Q41870373Perindopril may improve the hippocampal reduced glutathione content in rats
Q34229717Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor, omapatrilat in healthy subjects
Q54110304Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction.
Q33902193Pharmacological management of atrial fibrillation: one, none, one hundred thousand.
Q37978478Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury
Q23910430Phosphatidylinositol 3-kinase/Akt positively regulates fas (CD95)-mediated apoptosis in epidermal Cl41 cells
Q46150245Pigment epithelium-derived factor (PEDF) prevents platelet activation and aggregation in diabetic rats by blocking deleterious effects of advanced glycation end products (AGEs).
Q47839310Plasma detection of NO by a catheter
Q43919813Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure
Q44574645Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients
Q55114983Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice.
Q77709146Potential mechanisms for the effect of angiotensin-converting enzyme inhibitors on endothelial dysfunction: the role of nitric oxide
Q35118290Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia
Q39660661Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats
Q41949181Prednisolone augments superoxide formation in porcine pulmonary artery endothelial cells through differential effects on the expression of nitric oxide synthase and NADPH oxidase
Q34048574President's address. Common mechanisms of multiple diseases: why vegetables and exercise are good for you.
Q37002708Prevention of TGFβ induction attenuates angII-stimulated vascular biglycan and atherosclerosis in Ldlr-/- mice
Q36893345Prevention of aortic fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in angiotensin II-induced hypertension
Q82381723Preventive effects of syngeneic bone marrow transplantation on diabetic nephropathy in mice
Q33942155Prolonged fasting does not increase oxidative damage or inflammation in postweaned northern elephant seal pups
Q37169153Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis.
Q37381258Protection from reoxygenation injury by inhibition of rac1.
Q33729668Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene
Q94560950Protective Effects of Short-Chain Fatty Acids on Endothelial Dysfunction Induced by Angiotensin II
Q43182745Protective effect of sitagliptin and rosuvastatin combination on vascular endothelial dysfunction in type-2 diabetes.
Q42241241Protective effects of aspirin from cardiac hypertrophy and oxidative stress in cardiomyopathic hamsters
Q42526837Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes
Q35710671PsANT, the adenine nucleotide translocase of Puccinia striiformis, promotes cell death and fungal growth
Q33769358Pulmonary endothelial cell NOX
Q24298708Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions
Q38522640Quercetin glucuronide prevents VSMC hypertrophy by angiotensin II via the inhibition of JNK and AP-1 signaling pathway
Q43891469Quinacrine increases endothelial nitric oxide release: role of superoxide anion
Q34511006Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders
Q28396460ROS, Notch, and Wnt signaling pathways: crosstalk between three major regulators of cardiovascular biology
Q39396774ROS-modulated therapeutic approaches in cancer treatment.
Q36955833Radical-free biology of oxidative stress
Q28580234Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus
Q90734035Rapamycin Treatment Attenuates Angiotensin II -induced Abdominal Aortic Aneurysm Formation via VSMC Phenotypic Modulation and Down-regulation of ERK1/2 Activity
Q30491698Rationale for nebivolol/valsartan combination for hypertension: review of preclinical and clinical data
Q37376997Reactive oxygen and nitrogen species in pulmonary hypertension
Q50863678Reactive oxygen species and antioxidant defense in human gastrointestinal diseases.
Q36449410Reactive oxygen species and p47phox activation are essential for the Mycobacterium tuberculosis-induced pro-inflammatory response in murine microglia
Q34028162Reactive oxygen species and the control of vasomotor tone
Q33927958Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors
Q34019811Reactive oxygen species as mediators of angiotensin II signaling
Q37828680Reactive oxygen species as mediators of signal transduction in cardiovascular disease
Q46522556Reactive oxygen species derived from NADPH oxidase 1 and mitochondria mediate angiotensin II-induced smooth muscle cell senescence
Q35963391Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation.
Q43935541Reactive oxygen species differentially affect T cell receptor-signaling pathways.
Q37431048Reactive oxygen species in cancer
Q36674343Reactive oxygen species in the neuropathogenesis of hypertension
Q35874976Reactive oxygen species in vascular biology: implications in hypertension
Q37713975Reactive oxygen species mediate angiotensin II-induced transcytosis of low-density lipoprotein across endothelial cells.
Q33601934Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells
Q37361893Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability
Q36450264Reactive oxygen species signaling in vascular smooth muscle cells
Q36392238Reactive oxygen species: toxic molecules or spark of life?
Q36842628Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes
Q57117618Redox Balance, Antioxidant Defense, and Oxidative Damage in the Hypothalamus and Cerebral Cortex of Rats with High Fat Diet-Induced Insulin Resistance
Q46256827Redox Control of Vascular Function
Q38130100Redox balance in the aged endothelium.
Q37510851Redox control of the cell cycle in health and disease
Q33690103Redox control of vascular smooth muscle migration
Q63365790Redox control of vascular smooth muscle proliferation
Q35748228Redox regulation of angiotensin II signaling in the heart.
Q36476273Redox regulation of epidermal growth factor receptor signaling through cysteine oxidation
Q35296178Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transduction
Q37446110Redox signaling in cardiovascular health and disease.
Q46249417Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration.
Q44413513Redox-dependent MAP kinase signaling by Ang II in vascular smooth muscle cells: role of receptor tyrosine kinase transactivation
Q33957112Redox-dependent signal transduction
Q41880895Reduced angiotensin II levels cause generalized vascular dysfunction via oxidant stress in hamster cheek pouch arterioles.
Q84672976Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy
Q28361065Reduction of oxidative stress and AT1 receptor expression by the selective oestrogen receptor modulator idoxifene
Q35925959Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
Q37100479Regulation of T-cell function by endogenously produced angiotensin II.
Q30406156Regulation of cellular communication by signaling microdomains in the blood vessel wall
Q37430939Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure
Q35153563Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells
Q43577316Regulation of prostacyclin synthesis by angiotensin II and TNF-alpha in vascular smooth muscle
Q42809514Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
Q37058920Regulation of the renin-angiotensin system in coronary atherosclerosis: a review of the literature
Q37632261Reinventing the ACE inhibitors: some old and new implications of ACE inhibition
Q43648736Relationship between tumor necrosis factor-alpha production and oxidative stress in the failing hearts of patients with dilated cardiomyopathy
Q78107902Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function
Q28298575Relationship of the p22phox (CYBA) gene polymorphism C242T with risk of coronary artery disease: a meta-analysis
Q28082365Renal autoregulation in health and disease
Q34501842Renal denervation modulates angiotensin receptor expression in the renal cortex of rabbits with chronic heart failure.
Q37900203Renal dysfunction in acute heart failure: epidemiology, mechanisms and assessment
Q35203828Renin angiotensin system and gender differences in dopaminergic degeneration.
Q36458652Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
Q42098043Renin-Angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction
Q36784673Renin-angiotensin system and cardiovascular risk
Q39404819Renin-angiotensin system gene expression and neurodegenerative diseases
Q44260226Resistance to hyperoxia with heme oxygenase-1 disruption: role of iron
Q26821967Review article: pancreatic renin-angiotensin systems in health and disease
Q39700439Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors
Q35176118Rho-kinase/nuclear factor-κβ/angiotensinogen axis in angiotensin II-induced renal injury
Q48542818Robert Wayne Alexander, M.D., PH.D.
Q33965815Role for mitochondrial oxidants as regulators of cellular metabolism
Q28196501Role of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors, angiotensin-converting enzyme inhibitors, cyclooxygenase-2 inhibitors, and aspirin in anti-inflammatory and immunomodulatory treatment of cardiovascular diseases
Q38626384Role of Matrix Metalloproteinases in the Pathogenesis of Traumatic Brain Injury
Q36495144Role of NADPH oxidase and iNOS in vasoconstrictor responses of vessels from hypertensive and normotensive rats.
Q43263113Role of PKC in the attenuation of the cGMP-mediated relaxation of skinned resistance artery smooth muscle seen in glyceryl-trinitrate-tolerant rabbit
Q39238324Role of Tissue Renin-angiotensin System and the Chymase/angiotensin-(1-12) axis in the Pathogenesis of Diabetic Retinopathy
Q37808491Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes
Q77102720Role of angiotensin-converting enzyme inhibition in reversal of endothelial dysfunction in coronary artery disease
Q35172806Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model
Q39675810Role of mitochondrial-derived oxidants in renal tubular cell cold-storage injury
Q50497066Role of nitric oxide on the vasorelaxant effect of atrial natriuretic peptide on rabbit aorta basal tone.
Q37045445Role of oxidative stress and nitric oxide in atherothrombosis
Q42265679Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats
Q40378762Role of oxidative stress in angiotensin-II mediated contraction of human conduit arteries in patients with cardiovascular disease.
Q35581462Role of oxidative stress in disease progression in Stage B, a pre-cursor of heart failure
Q36525653Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II.
Q36229028Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction
Q30424339Role of the immune system in hypertension: modulation by dietary antioxidants
Q34306932Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of vein graft failure?
Q36890881Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid
Q37167578Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress
Q34046462Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension
Q28594591Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
Q37688383Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow
Q36929431Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1.
Q41994308Rutin as a Mediator of Lipid Metabolism and Cellular Signaling Pathways Interactions in Fibroblasts Altered by UVA and UVB Radiation.
Q35582293SOXF: redox mediators of vascular smooth muscle cell growth
Q38693277Salt, Angiotensin II, Superoxide, and Endothelial Function
Q37778985Salt, aldosterone, and insulin resistance: impact on the cardiovascular system
Q49921149Sex Differences in Abdominal Aortic Aneurysms.
Q90492111Sildenafil Protects Endothelial Cells From Radiation-Induced Oxidative Stress
Q42324363Simvastatin and losartan differentially and synergistically inhibit atherosclerosis in apolipoprotein e(-/-) mice
Q54917997Skeletal muscle bioenergetics in aging and heart failure.
Q35939806Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells
Q38072702Smoking in diabetic nephropathy: sparks in the fuel tank?
Q34280178Smooth muscle cell apoptosis in arteriosclerosis
Q48919718Sodium and Potassium Relating to Parkinson's Disease and Traumatic Brain Injury.
Q31149563Sodium ferulate inhibits neointimal hyperplasia in rat balloon injury model
Q92022823Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction
Q58075704Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Q35936804Statin therapy for cardiac hypertrophy and heart failure
Q35828423Statins and myocardial hypertrophy
Q36110624Statins and the myocardium
Q41972833Stimulation of arterial smooth muscle L-type calcium channels by hydrogen peroxide requires protein kinase C.
Q35178628Stressing the system.
Q30519970Sub-Nanomolar Sensitivity of Nitric Oxide Mediated Regulation of cGMP and Vasomotor Reactivity in Vascular Smooth Muscle
Q58125911Superoxide Dismutase Activity in Small Mesenteric Arteries Is Downregulated by Angiotensin II but Not by Hypertension
Q35045534Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice
Q34455923Superoxide generation of phagocytes and nonphagocytic cells
Q53647150Superoxide production and oxygen consumption in endothelium-intact and -denuded artery stimulated by angiotensin II.
Q77379588Superoxide scavenging effect of Ginkgo biloba extract on serotonin-induced mitogenesis
Q46322063Suppression of atrial natriuretic peptide/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts
Q53592062Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice.
Q41573480Sympathetic Overactivity in Chronic Kidney Disease: Consequences and Mechanisms
Q36193746Sympathetic regulation of vascular function in health and disease.
Q37352389Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension
Q36702981Tanshinone IIA and Cryptotanshinone Prevent Mitochondrial Dysfunction in Hypoxia-Induced H9c2 Cells: Association to Mitochondrial ROS, Intracellular Nitric Oxide, and Calcium Levels
Q26863500Targeting NADPH oxidases in vascular pharmacology
Q37376499Targeting cardiac sympatho-vagal imbalance using gene transfer of nitric oxide synthase
Q38009736Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors
Q51034962Telmisartan ameliorates neurotrophic support and oxidative stress in the retina of streptozotocin-induced diabetic rats.
Q35036184Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol-induced atherosclerosis
Q46907016Temporal effects of low-dose ACE inhibition on endothelial function in Type 1 diabetic patients
Q43264469Tetrahydrobiopterin impairs the action of endothelial nitric oxide via superoxide derived from platelets
Q58696656The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension
Q89719234The Effect of N-Acetylcysteine on Respiratory Enzymes, ADP/ATP Ratio, Glutathione Metabolism, and Nitrosative Stress in the Salivary Gland Mitochondria of Insulin Resistant Rats
Q58710605The Effect of Sea Buckthorn ( L.) Seed Oil on UV-Induced Changes in Lipid Metabolism of Human Skin Cells
Q92241256The Impact of High-Fat Diet on Mitochondrial Function, Free Radical Production, and Nitrosative Stress in the Salivary Glands of Wistar Rats
Q42945503The Jeremiah Metzger Lecture. Pathogenesis of atherosclerosis: redox as a unifying mechanism.
Q39123362The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction
Q38241109The acute cardiorenal syndrome: burden and mechanisms of disease
Q37309054The antihypertensive effect of arginine
Q37291570The antihypertensive effect of cysteine
Q34340391The cardiorenal syndrome: making the connection
Q35548796The clinical implications of endothelial dysfunction
Q90299244The contribution of chymase-dependent formation of ANG II to cardiac dysfunction in metabolic syndrome of young rats: roles of fructose and EETs
Q46435677The effects of the overexpression of recombinant uncoupling protein 2 on proliferation, migration and plasminogen activator inhibitor 1 expression in human vascular smooth muscle cells
Q73357066The influence of endogenously generated reactive oxygen species on the inotropic and chronotropic effects of adrenoceptor and ET-receptor stimulation
Q73193166The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity
Q28578712The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells
Q36102167The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration
Q38074245The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension
Q34060768The multiple actions of angiotensin II in atherosclerosis
Q28144464The p22 phox A640G gene polymorphism but not the C242T gene variation is associated with coronary heart disease in younger individuals
Q64990581The pathophysiological basis of vascular disease.
Q41540463The physiology and pathophysiology of the nitric oxide/superoxide system
Q37361567The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure
Q33632757The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls
Q28609860The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study
Q42451386The receptors and role of angiotensin II in knee joint blood flow regulation and role of nitric oxide in modulation of their function
Q37475546The renin angiotensin aldosterone system in hypertension: roles of insulin resistance and oxidative stress
Q36442587The renin-angiotensin system and atherosclerosis
Q36424627The role of Nox-mediated oxidation in the regulation of cytoskeletal dynamics
Q42043961The role of adrenomedullin in the renal NADPH oxidase and (pro)renin in diabetic mice
Q38253635The role of local renin-angiotensin system in arterial chemoreceptors in sleep-breathing disorders
Q61843052The role of nitric oxide in the regulation of myocardial relaxation and diastolic function
Q62647447The role of oxidant stress in angiotensin II-mediated contraction of human resistance arteries in the state of health and the presence of cardiovascular disease
Q39936328The role of urate and xanthine oxidase in vascular oxidative stress: future directions
Q46391414The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease.
Q37178255The sweeter side of ACE2: physiological evidence for a role in diabetes
Q35090364The therapeutic effect of natriuretic peptides in heart failure; differential regulation of endothelial and inducible nitric oxide synthases
Q30824712The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
Q42521764The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.
Q35026157Therapeutic inhibition of tumour necrosis factor alpha in patients with heart failure: cooling an inflamed heart.
Q46224925Thiol antioxidants regulate angiotensin II AT1 and arginine vasopressin V1 receptor functions differently in vascular smooth muscle cells
Q40529148Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide.
Q39711485Thyroid hormone induces artery smooth muscle cell proliferation: discovery of a new TRalpha1-Nox1 pathway
Q35809634Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction
Q35740783Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3beta activation
Q42519570Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state
Q37709969Total flavonoids from Plumula Nelumbinis suppress angiotensin II-induced fractalkine production by inhibiting the ROS/NF-κB pathway in human umbilical vein endothelial cells
Q46428405Trace analysis of oxidized, nitrated, and chlorinated aromatic amino acids by capillary electrophoresis with electroosmotic flow modification allowing large-volume sample stacking
Q37615958Translating the oxidative stress hypothesis into the clinic: NOX versus NOS.
Q44599816Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy
Q35083719Transplasma membrane electron transport: enzymes involved and biological function.
Q28583958Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle
Q73222605Tyrosine and calcium/calmodulin kinases are common signaling components in the generation of reactive oxygen species in human lymphocytes
Q24291589Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox
Q34022338Tyrosine nitration of PA700 activates the 26S proteasome to induce endothelial dysfunction in mice with angiotensin II-induced hypertension
Q24650649Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction
Q88181434Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology
Q28576215Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy
Q40765724Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo
Q42804909Uric acid induces oxidative stress via an activation of the renin-angiotensin system in 3T3-L1 adipocytes
Q35245800Urinary Angiotensinogen as a Novel Biomarker of Intrarenal Renin-Angiotensin System in Chronic Kidney Disease
Q42861889Urinary angiotensinogen as a biomarker of nephropathy in childhood
Q37135790Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients
Q36951760Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases
Q33940516Urinary angiotensinogen is correlated with blood pressure in men (Bogalusa Heart Study).
Q34167806Valsartan improves endothelial dysfunction in hypertension: a randomized, double-blind study.
Q50211596Vascular Smooth Muscle Contraction in Hypertension.
Q26774561Vascular endothelial dysfunction and pharmacological treatment
Q49671689Vascular endothelium dysfunction: a conservative target in metabolic disorders.
Q35689010Vascular injury in systemic sclerosis: angiotensin-converting enzyme insertion/deletion polymorphism
Q73978566Vascular oxidant stress early after balloon injury: evidence for increased NAD(P)H oxidoreductase activity
Q33957964Vascular oxidant stress: molecular mechanisms and pathophysiological implications
Q35037357Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species
Q35027751Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis
Q33701956Vasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat.
Q37102203Water-Soluble Components of Sesame Oil Reduce Inflammation and Atherosclerosis
Q44940405Xanthine oxidase inhibition by 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), an antagonist of adenosine receptors.
Q36116868Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases
Q74043506[Current topics in vascular biology: an update for the 21st century]
Q35696706p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice
Q28364478p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice
Q36564448rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation
Q47120802Δ9-Tetrahydrocannabinol Prevents Cardiovascular Dysfunction in STZ-Diabetic Wistar-Kyoto Rats.
Q46628069α-lipoic acid reduces hypertension and increases baroreflex sensitivity in renovascular hypertensive rats
Q42482105α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation

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