Structure of protein interaction networks and their implications on drug design

scientific article

Structure of protein interaction networks and their implications on drug design is …
instance of (P31):
scholarly articleQ13442814

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P8978DBLP publication IDjournals/ploscb/HaseTSNK09
P356DOI10.1371/JOURNAL.PCBI.1000550
P932PMC publication ID2760708
P698PubMed publication ID19876376
P5875ResearchGate publication ID38054824

P50authorSo NakagawaQ39068698
P2093author name stringHiroshi Tanaka
Takeshi Hase
Yasuhiro Suzuki
Hiroaki Kitano
P2860cites workTowards a proteome-scale map of the human protein–protein interaction networkQ21735930
Scale-free networks in cell biologyQ22306161
A robustness-based approach to systems-oriented drug designQ51062307
A network solutionQ53527430
Growing network with local rules: preferential attachment, clustering hierarchy, and degree correlationsQ73478873
Scale-rich metabolic networksQ81764933
Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networksQ82855583
DrugBank: a comprehensive resource for in silico drug discovery and explorationQ24188653
MPact: the MIPS protein interaction resource on yeastQ24538008
The human disease networkQ24678240
Protein complexes and functional modules in molecular networksQ24683305
Network biology: understanding the cell's functional organizationQ27861027
Collective dynamics of 'small-world' networksQ27861064
Global mapping of the yeast genetic interaction networkQ27934987
Specificity and stability in topology of protein networksQ28216450
Drug-target networkQ29614447
Evidence for dynamically organized modularity in the yeast protein-protein interaction networkQ29614449
Stratus not altocumulus: a new view of the yeast protein interaction networkQ33258019
The "robust yet fragile" nature of the InternetQ34056048
Quantitative systems-level determinants of human genes targeted by successful drugs.Q36388813
Network properties of genes harboring inherited disease mutationsQ36670355
Towards a theory of biological robustnessQ42560167
Birth of scale-free molecular networks and the number of distinct DNA and protein domains per genome.Q48337100
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectprotein designQ410814
protein structureQ735188
P304page(s)e1000550
P577publication date2009-10-01
P1433published inPLOS Computational BiologyQ2635829
P1476titleStructure of protein interaction networks and their implications on drug design
P478volume5

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cites work (P2860)
Q34168896A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways
Q38193097A conceptual review on systems biology in health and diseases: from biological networks to modern therapeutics
Q92496939A dual controllability analysis of influenza virus-host protein-protein interaction networks for antiviral drug target discovery
Q83307544A novel paradigm for potential drug-targets discovery: quantifying relationships of enzymes and cascade interactions of neighboring biological processes to identify drug-targets
Q38046230Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).
Q53175427Assessing Relative Bioactivity of Chemical Substances Using Quantitative Molecular Network Topology Analysis
Q38243624Biological networks and drug discovery--where do we stand?
Q50420648Building protein-protein interaction networks for Leishmania species through protein structural information.
Q36477635Cardioprotective Effects of Qishenyiqi Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin-Converting Enzyme 2
Q37784556Cause-effect relationships in medicine: a protein network perspective
Q51530606Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry?
Q39768567Cross-Disciplinary Network Comparison: Matchmaking Between Hairballs
Q34552423Dissecting the human protein-protein interaction network via phylogenetic decomposition
Q28551715Distinctive Behaviors of Druggable Proteins in Cellular Networks
Q50934746Disturbed protein-protein interaction networks in metastatic melanoma are associated with worse prognosis and increased functional mutation burden
Q36123974Diverse array-designed modes of combination therapies in Fangjiomics
Q35846066Drug Target Prediction Based on the Herbs Components: The Study on the Multitargets Pharmacological Mechanism of Qishenkeli Acting on the Coronary Heart Disease
Q30577213Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction.
Q36480634Evolutionary Model Selection and Parameter Estimation for Protein-Protein Interaction Network Based on Differential Evolution Algorithm
Q41495324Evolutionary analysis and interaction prediction for protein-protein interaction network in geometric space
Q30413339From QSAR models of drugs to complex networks: state-of-art review and introduction of new Markov-spectral moments indices
Q36565116Functional analysis of long intergenic non-coding RNAs in phosphate-starved rice using competing endogenous RNA network
Q40267048Identification of drug-target interaction from interactome network with 'guilt-by-association' principle and topology features
Q49363717Identification of prognostic signature in cancer based on DNA methylation interaction network
Q30000682Inferring gene dependency network specific to phenotypic alteration based on gene expression data and clinical information of breast cancer
Q41863562Inferring multi-target QSAR models with taxonomy-based multi-task learning.
Q45835957Integrated gene co-expression network analysis in the growth phase of Mycobacterium tuberculosis reveals new potential drug targets.
Q50511044Interactions of Hemoglobin in Live Red Blood Cells Measured by the Electrophoresis Release Test
Q50567915Interactions of hemoglobin in live red blood cells measured by the electrophoresis release test
Q35089917Intercellular Interactomics of Human Brain Endothelial Cells and Th17 Lymphocytes: A Novel Strategy for Identifying Therapeutic Targets of CNS Inflammation
Q92962253Measuring rank robustness in scored protein interaction networks
Q36938251Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells
Q27444499Network connectivity during mergers and growth: Optimizing the addition of a module
Q28479003Network neighbors of drug targets contribute to drug side-effect similarity
Q60301188Network-Guided Discovery of Influenza Virus Replication Host Factors
Q27691333Network-based characterization of drug-regulated genes, drug targets, and toxicity
Q38066338On the functional and structural characterization of hubs in protein–protein interaction networks
Q36910814Proteome-wide Prediction of Self-interacting Proteins Based on Multiple Properties
Q43784080Reduction of Complex Signaling Networks to a Representative Kernel
Q28541382Robustness and evolvability of the human signaling network
Q27008867Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
Q30577130SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations
Q28082555Systems Biology for Smart Crops and Agricultural Innovation: Filling the Gaps between Genotype and Phenotype for Complex Traits Linked with Robust Agricultural Productivity and Sustainability
Q34223105Systems analysis of inflammatory bowel disease based on comprehensive gene information.
Q35864807Systems biology of fungal infection.
Q37860613Systems biology of tuberculosis
Q28534621Target Essentiality and Centrality Characterize Drug Side Effects
Q40513256Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations
Q34508185Topology of molecular interaction networks
Q33588662VAN: an R package for identifying biologically perturbed networks via differential variability analysis
Q38011629Visualization of the interactome: what are we looking at?
Q47252941gene2drug: a Computational Tool for Pathway-based Rational Drug Repositioning

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