Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases

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Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases is …
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P356DOI10.1002/1439-7633(20020402)3:4<274::AID-CBIC274>3.0.CO;2-S
P698PubMed publication ID11933228

P50authorAlbert JeltschQ30003285
P2860cites workCircular Permutations in the Molecular Evolution of DNA MethyltransferasesQ21045391
Role of DNA 5-methylcytosine transferase in cell transformation by fosQ22008665
Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 geneQ48371609
The sins of the fathers and mothers: genomic imprinting in mammalian development.Q50532990
A short DNA methyltransferase isoform restores methylation in vivo.Q50741462
Genetics. Do X chromosomes set boundaries?Q52125291
Mouse DNA methyltransferase (MTase) deletion mutants that retain the catalytic domain display neither de novo nor maintenance methylation activity in vivo.Q52194719
DNA hypomethylation can activate Xist expression and silence X-linked genes.Q52200238
Masc2, a gene from Ascobolus encoding a protein with a DNA-methyltransferase activity in vitro, is dispensable for in vivo methylation.Q52533862
Mammalian (cytosine-5) methyltransferases cause genomic DNA methylation and lethality in Drosophila.Q52573989
Genomic imprinting. Silence across the border.Q52579639
DNA methylation in Drosophila melanogaster.Q52584665
Timing and targeting: the biological functions of Dam methylation in E. coli.Q53041382
Amino acid sequence arrangements of DNA-methyltransferasesQ53753431
Activation of a yeast pseudo DNA methyltransferase by deletion of a single amino acid.Q54590338
Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structureQ56256578
BASE FLIPPINGQ56256582
On the Substrate Specificity of DNA MethyltransferasesQ57267693
The amazing demethylaseQ58996826
Growing Y-junction carbon nanotubesQ59048574
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumorsQ22010018
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Translating the Histone CodeQ22065840
Instability and decay of the primary structure of DNAQ22122361
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication fociQ22254582
Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1Q22299424
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2Q22337290
A candidate mammalian DNA methyltransferase related to pmt1p of fission yeastQ24318996
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcriptionQ24534441
2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferasesQ24546328
Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cellsQ24548031
Structure and function of type II restriction endonucleasesQ24555230
Three-dimensional structure of the adenine-specific DNA methyltransferase M.Taq I in complex with the cofactor S-adenosylmethionineQ24562671
The DNA (cytosine-5) methyltransferasesQ24614934
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNAQ24621648
Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissuesQ24655349
Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivationQ24678487
Structure of RsrI methyltransferase, a member of the N6-adenine beta class of DNA methyltransferasesQ27627400
Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analogQ27629529
The crystal structure of Haelll methyltransferase covalently complexed to DNA: An extrahelical cytosine and rearranged base pairingQ27729758
HhaI methyltransferase flips its target base out of the DNA helixQ27731553
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionineQ27731970
Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexesQ27733356
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqIQ27734381
Structure of pvu II DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignmentQ27739964
DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferaseQ27739981
Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target baseQ27765722
Crystal structure of the DpnM DNA adenine methyltransferase from the DpnII restriction system of streptococcus pneumoniae bound to S-adenosylmethionineQ27766381
The genome sequence of Drosophila melanogasterQ27860796
Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityQ28131773
A vicious cycle: RNA silencing and DNA methylation in plantsQ34340509
Recognition and cleavage of DNA by type-II restriction endonucleasesQ34431350
A gene essential for de novo methylation and development in Ascobolus reveals a novel type of eukaryotic DNA methyltransferase structureQ34444089
Cloning and analysis of a novel human putative DNA methyltransferaseQ34469056
The fission yeast gene pmt1+ encodes a DNA methyltransferase homologueQ34734767
HhaI and HpaII DNA methyltransferases bind DNA mismatches, methylate uracil and block DNA repairQ34746885
DNA hypomethylation leads to elevated mutation ratesQ34752442
A microfabricated device for sizing and sorting DNA moleculesQ34786723
Enhancement of cellulose production by expression of sucrose synthase in Acetobacter xylinumQ34787027
The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNAQ34811750
Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coliQ35059178
The essentials of DNA methylationQ35326024
Conserved plant genes with similarity to mammalian de novo DNA methyltransferases.Q35702821
Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasiaQ35860006
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotideQ35960841
A cell cycle-regulated adenine DNA methyltransferase from Caulobacter crescentus processively methylates GANTC sites on hemimethylated DNAQ35974019
Methylation of genomes and genes at the invertebrate-vertebrate boundaryQ36565952
Analysis of CpG suppression in methylated and nonmethylated speciesQ36812188
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.Q36967574
Restriction and modification systemsQ37041891
Developmental abnormalities and epimutations associated with DNA hypomethylation mutationsQ37239186
Sequence-specific recognition of cytosine C5 and adenine N6 DNA methyltransferases requires different deformations of DNA.Q37428515
Allosteric and catalytic binding of S-adenosylmethionine to Escherichia coli DNA adenine methyltransferase monitored by 3H NMRQ37553015
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosineQ37576837
A cell cycle-regulated bacterial DNA methyltransferase is essential for viabilityQ37734558
Role of DNA minor groove interactions in substrate recognition by the M.SinI and M.EcoRII DNA (cytosine-5) methyltransferasesQ38298515
The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferaseQ38302392
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG islandQ38303631
Molecular enzymology of the EcoRV DNA-(Adenine-N (6))-methyltransferase: kinetics of DNA binding and bending, kinetic mechanism and linear diffusion of the enzyme on DNA.Q38307807
DNA bending induced by DNA (cytosine-5) methyltransferasesQ38309734
Binding of EcoP15I DNA methyltransferase to DNA reveals a large structural distortion within the recognition sequenceQ38312746
Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferaseQ38315517
Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna.Q38318722
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promotersQ28140428
Characterization of the human DNA methyltransferase splice variant Dnmt1bQ28141132
DNA methyltransferase Dnmt1 associates with histone deacetylase activityQ28141500
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 geneQ28145754
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locusQ28145756
The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNAQ28201053
CTCF, a candidate trans-acting factor for X-inactivation choiceQ28211023
Epigenetic reprogramming in mammalian developmentQ28212171
Purification of CpG islands using a methylated DNA binding columnQ28243902
Hypermethylated SUPERMAN epigenetic alleles in arabidopsisQ28246520
Functional expression of soluble human interleukin-11 (IL-11) receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130Q28298093
Arabidopsis cmt3 chromomethylase mutations block non-CG methylation and silencing of an endogenous geneQ28344278
dim-2 encodes a DNA methyltransferase responsible for all known cytosine methylation in NeurosporaQ28345107
Maize chromomethylase Zea methyltransferase2 is required for CpNpG methylationQ28345515
Chromosomal DNA demethylation specified by protein bindingQ28360836
Glucocorticoid-induced DNA demethylation and gene memory during developmentQ28362233
Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sitesQ28506872
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferasesQ28507226
Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylationQ28609169
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cellsQ29399636
Interspersed repeats and other mementos of transposable elements in mammalian genomesQ29615764
Genomic imprinting: parental influence on the genomeQ29616227
A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nucleiQ29616800
The DNA methyltransferases of mammalsQ29617317
The role of DNA methylation in mammalian epigeneticsQ29617979
Cytosine methylation and the ecology of intragenomic parasitesQ29618264
Role for DNA methylation in genomic imprintingQ29618669
Transcription of IAP endogenous retroviruses is constrained by cytosine methylationQ29618745
Plant DNA methyltransferases.Q30327264
Molecular evolution of DNA-(cytosine-N4) methyltransferases: evidence for their polyphyletic originQ30583278
DNA methylation in health and diseaseQ30659938
Human DNA repair genesQ31963889
DNA demethylationQ33642025
Epigenetics: regulation through repressionQ33751823
Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylationQ43604842
The cytosine N4-methyltransferase M.PvuII also modifies adenine residuesQ43639216
Mechanism-based inhibition of an essential bacterial adenine DNA methyltransferase: rationally designed antibioticsQ43677158
Gene may promise new route to potent vaccinesQ43683582
How does a DNA interacting enzyme change its specificity during molecular evolution? A site-directed mutagenesis study at the DNA binding site of the DNA-(adenine-N6)-methyltransferase EcoRV.Q43733371
DNA from Aspergillus flavus contains 5-methylcytosineQ43812475
Facilitated diffusion of the EcoRI DNA methyltransferase is described by a novel mechanismQ46157592
Contribution of facilitated diffusion and processive catalysis to enzyme efficiency: implications for the EcoRI restriction-modification systemQ46529890
Targeted base stacking disruption by the EcoRI DNA methyltransferaseQ46567946
Vestiges of a DNA methylation system in Drosophila melanogaster?Q47072085
Functional roles of conserved amino acid residues in DNA methyltransferases investigated by site-directed mutagenesis of the EcoRV adenine-N6-methyltransferaseQ47892200
Hypermutation in pathogenic bacteria: frequent phase variation in meningococci is a phenotypic trait of a specialized mutator biotype.Q47967206
Nonmethylated transposable elements and methylated genes in a chordate genomeQ47987079
Characterisation of independent DNA and multiple Zn-binding domains at the N terminus of human DNA-(cytosine-5) methyltransferase: modulating the property of a DNA-binding domain by contiguous Zn-binding motifsQ48064755
Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymesQ48069333
SeqA: a negative modulator of replication initiation in E. coliQ48082693
Aberrant methylation of donor genome in cloned bovine embryosQ48362498
The establishment and maintenance of DNA methylation patterns in mouse somatic cellsQ33765663
Methylation moves into medicineQ33831348
Cytosine methylation and human cancerQ33845225
DNA hypermethylation in tumorigenesis: epigenetics joins geneticsQ33870798
An epigenetic mutation responsible for natural variation in floral symmetryQ33874385
Diversity of homology-dependent gene silencing strategies in fungiQ33879824
Active demethylation of the paternal genome in the mouse zygoteQ33901068
X-chromosome inactivation: counting, choice and initiationQ33938436
A dual role for substrate S-adenosyl-L-methionine in the methylation reaction with bacteriophage T4 Dam DNA-[N6-adenine]-methyltransferaseQ33938784
Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferasesQ33941798
AdoMet-dependent methylation, DNA methyltransferases and base flippingQ33941847
C(m)C(a/t)GG methylation: a new epigenetic mark in mammalian DNA?Q33942908
Mobilization of transposons by a mutation abolishing full DNA methylation in ArabidopsisQ33946286
In vivo gene expression and the adaptive response: from pathogenesis to vaccines and antimicrobialsQ33955498
RNA interference and small interfering RNAsQ33957221
X inactivation, differentiation, and DNA methylationQ33999850
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.Q34012712
RNA-directed DNA methylation.Q34041209
Transgene silencing by the host genome defense: implications for the evolution of epigenetic control mechanisms in plants and vertebratesQ34041294
A cytosine methyltransferase converts 5-methylcytosine in DNA to thymine.Q34058041
DNA methylation and epigenetic inheritance in plants and filamentous fungiQ34086436
Nuclear cloning and epigenetic reprogramming of the genomeQ34086441
Methyl-CpG-binding proteins. Targeting specific gene repression.Q34106217
Local DNA demethylation in vertebrates: how could it be performed and targeted?Q34224548
Loss of methylation activates Xist in somatic but not in embryonic cellsQ34295214
Emerging connections between DNA methylation and histone acetylation.Q34298959
DNA modification by methyltransferasesQ34312461
DpnA, a methylase for single-strand DNA in the Dpn II restriction system, and its biological functionQ34322511
REBASE--restriction enzymes and methylases.Q34323893
Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene.Q38318863
Mutational analysis of target base flipping by the EcoRV adenine-N6 DNA methyltransferaseQ38329103
Interaction of the type I methyltransferase M.EcoR124I with modified DNA substrates: sequence discrimination and base flippingQ38330725
Kinetic mechanism of the EcoRI DNA methyltransferaseQ38336068
Functional mapping of the EcoRV DNA methyltransferase by random mutagenesis and screening for catalytically inactive mutantsQ38336594
Kinetics of methylation and binding of DNA by the EcoRV adenine-N6 methyltransferaseQ38339339
Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication fociQ38339378
Direct real time observation of base flipping by the EcoRI DNA methyltransferaseQ38340696
Control of methylation spreading in synthetic DNA sequences by the murine DNA methyltransferaseQ38344869
Angle and locus of the bend induced by the msp I DNA methyltransferase in a sequence-specific complex with DNAQ38345982
DNA distortion and base flipping by the EcoRV DNA methyltransferase. A study using interference at dA and T bases and modified deoxynucleosidesQ38349483
Murine DNA cytosine-C5 methyltransferase: pre-steady- and steady-state kinetic analysis with regulatory DNA sequencesQ38356751
Masc2, a C5-DNA-methyltransferase from Ascobolus immersus with similarity to methyltransferases of higher organismsQ38553740
The great GATC: DNA methylation in E. coliQ38670595
Changing the target base specificity of the EcoRV DNA methyltransferase by rational de novo protein-designQ39096547
In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3bQ39449285
Protein binding protects sites on stable episomes and in the chromosome from de novo methylationQ39530432
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferaseQ39584589
Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryosQ39645050
DNA methylation in Escherichia coliQ39696712
Substrate DNA and cofactor regulate the activities of a multi-functional restriction-modification enzyme, BcgI.Q39721172
Chemical display of thymine residues flipped out by DNA methyltransferasesQ39724595
Repression of the mouse M-lysozyme gene involves both hindrance of enhancer factor binding to the methylated enhancer and histone deacetylationQ39725865
DNA of Drosophila melanogaster contains 5-methylcytosineQ40388507
Functional analysis of Gln-237 mutants of HhaI methyltransferaseQ40393086
M.HhaI binds tightly to substrates containing mismatches at the target baseQ40393755
The role of the preserved sequences of Dam methylaseQ40408315
On base flippingQ40442261
Structure and Function of DNA MethyltransferasesQ40475987
Gene number, noise reduction and biological complexityQ40514856
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coliQ40518903
Eukaryotic DNA methyltransferases--structure and functionQ40523967
DNA methyltransferasesQ40626444
An essential role for DNA adenine methylation in bacterial virulenceQ40639021
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulationQ40834659
Inhibition of DNA methyltransferase inhibits DNA replicationQ40874851
Peptide Mapping of the Murine DNA Methyltransferase Reveals a Major Phosphorylation Site and the Start of TranslationQ40886990
Cis-elements required for the demethylation of the mouse M-lysozyme downstream enhancerQ41094257
Finding a basis for flipping bases.Q41111081
The role of DNA methylation in cancer genetic and epigeneticsQ41291310
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesisQ41351086
DNA methylation: a molecular lockQ41441579
Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flippingQ41630752
Measurement of the absolute temporal coupling between DNA binding and base flippingQ41648450
How does DNA methylation repress transcription?Q41653866
High frequency mutagenesis by a DNA methyltransferaseQ41917002
Asymmetry of Dam remethylation on the leading and lagging arms of plasmid replicative intermediatesQ42017660
Sp1 elements protect a CpG island from de novo methylationQ42497349
Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution.Q42636190
A histone H3 methyltransferase controls DNA methylation in Neurospora crassaQ42664087
P433issue4
P921main subjectDNA methylationQ874745
P304page(s)274-293
P577publication date2002-04-01
P1433published inChemBioChemQ634395
P1476titleBeyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases
P478volume3

Reverse relations

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Q34733206Expression profiling and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in sporadic human renal cell carcinoma.
Q33576388Expression, crystallization and preliminary X-ray diffraction analysis of a modification subunit of a putative type I restriction enzyme from Vibrio vulnificus YJ016.
Q37000640Extrahelical damaged base recognition by DNA glycosylase enzymes
Q30440250Flexibility of the linker between the domains of DNA methyltransferase SsoII revealed by small-angle X-ray scattering: implications for transcription regulation in SsoII restriction-modification system.
Q39063397Flow signaling and atherosclerosis
Q28261711Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis
Q33808269Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis
Q58795332Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro
Q36986768Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L.
Q49495147From Bioengineering to CRISPR/Cas9 - A Personal Retrospective of 20 Years of Research in Programmable Genome Targeting
Q52571195Functional analysis of amino acid residues at the dimerisation interface of KpnI DNA methyltransferase.
Q28477117Functional analysis of an acid adaptive DNA adenine methyltransferase from Helicobacter pylori 26695
Q44885640Functional characterization of Escherichia coli DNA adenine methyltransferase, a novel target for antibiotics
Q36725000Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline
Q26741878Genetic and epigenetic mechanisms in the development of arteriovenous malformations in the brain
Q36984689Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models
Q54550758Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells.
Q38172016Genomic imprinting--the struggle of the genders at the molecular level
Q51149871HAMP promoter hypomethylation and increased hepcidin levels as biomarkers for Kawasaki disease.
Q50892860Histone Deacetylase 1 Regulates the Expression of Progesterone Receptor A During Human Parturition by Occupying the Progesterone Receptor A Promoter.
Q43208461Homology modeling and molecular dynamics simulations of HgiDII methyltransferase in complex with DNA and S-adenosyl-methionine: catalytic mechanism and interactions with DNA.
Q45097662Homology modeling of the CG-specific DNA methyltransferase SssI and its complexes with DNA and AdoHcy
Q33936519Homology-dependent methylation in primate repetitive DNA.
Q28115796Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism
Q92928350Hypomethylation of nerve growth factor (NGF) promotes binding of C/EBPα and contributes to inflammatory hyperalgesia in rats
Q30354798Identification of a DNA methyltransferase gene carried on a pathogenicity island-like element (VPAI) in Vibrio parahaemolyticus and its prevalence among clinical and environmental isolates.
Q33996334Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components
Q31133308Implementation and Data Analysis of Tn-seq, Whole-Genome Resequencing, and Single-Molecule Real-Time Sequencing for Bacterial Genetics
Q37067654Importance of methyl donors during reproduction
Q41366977In vivo DNA protection by relaxed-specificity SinI DNA methyltransferase variants
Q64081934Increase expression of CD177 in Kawasaki disease
Q28834498Influence of major-groove chemical modifications of DNA on transcription by bacterial RNA polymerases
Q58576156Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective
Q21144438Kinetic analysis of Yersinia pestis DNA adenine methyltransferase activity using a hemimethylated molecular break light oligonucleotide
Q93380766Kinetic and catalytic properties of M.HpyAXVII, a phase-variable DNA methyltransferase from Helicobacter pylori
Q46624243Label-free colorimetric assay for DNA methylation based on unmodified Au nanorods as a signal sensing probe coupled with enzyme-linkage reactions
Q52596119Large Diversity of Nonstandard Genes and Dynamic Evolution of Chloroplast Genomes in Siphonous Green Algae (Bryopsidales, Chlorophyta).
Q102206482Lnc-MAP3K13-7:1 inhibits ovarian granulosa cell proliferation in polycystic ovary syndrome through DNMT1 down-regulation mediated CDKN1A promoter hypomethylation
Q44625634Maintenance of species identity and controlling speciation of bacteria: a new function for restriction/modification systems?
Q34157833Making memories that last a lifetime: heritable functions of self-renewing memory CD8 T cells
Q36150116Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations
Q57167095Mammalian DNA methyltransferases: new discoveries and open questions
Q38845904Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation.
Q38797211Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges
Q45117060Mechanistic details of the DNA recognition by the Dnmt1 DNA methyltransferase
Q34672769Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism
Q27640940Methyltransferase That Modifies Guanine 966 of the 16 S rRNA: FUNCTIONAL IDENTIFICATION AND TERTIARY STRUCTURE
Q42257937Methyltransferase-directed covalent coupling of fluorophores to DNA.
Q38826180Methyltransferase-like 17 physically and functionally interacts with estrogen receptors
Q21245768MiR-185 targets the DNA methyltransferases 1 and regulates global DNA methylation in human glioma
Q51711929MicroRNA, epigenetic machinery and lung cancer.
Q57493383MicroRNA-129-5p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting DNMT3A
Q24643430MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer
Q24564757MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
Q33814564MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway
Q34974769Microarray evidences the role of pathologic adipose tissue in insulin resistance and their clinical implications
Q34598959MmeI: a minimal Type II restriction-modification system that only modifies one DNA strand for host protection
Q59813592Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes
Q34143019Molecular and Enzymatic Profiles of Mammalian DNA Methyltransferases: Structures and Targets for Drugs
Q38011287Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor
Q28487027Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs
Q36398727Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis
Q44086209Mutations in hpyAVIBM, C⁵ cytosine DNA methyltransferase from Helicobacter pylori result in relaxed specificity
Q39312657Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?
Q34412767Nontypeable Haemophilus influenzae genetic islands associated with chronic pulmonary infection
Q31130904Novel Methyltransferase Recognition Motif Identified in Chania multitudinisentens RB-25(T) gen. nov., sp. nov
Q36726812Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline
Q38876119Omics-based approaches to understand mechanosensitive endothelial biology and atherosclerosis
Q34091253On the evolutionary origin of eukaryotic DNA methyltransferases and Dnmt2.
Q36468143Perinatal choline influences brain structure and function
Q37315686Pharmacodynamic study of disulfiram in men with non-metastatic recurrent prostate cancer
Q46119911Phosphorothioation of oligonucleotides strongly influences the inhibition of bacterial (M.HhaI) and human (Dnmt1) DNA methyltransferases
Q40239920Physcomitrella patens DNA methyltransferase 2 is required for recovery from salt and osmotic stress
Q30985843Prediction of Plant Height in Arabidopsis thaliana Using DNA Methylation Data
Q38322396Probing murine methyltransfease Dnmt3a interactions with benzo[a]pyrene-modified DNA by fluorescence methods
Q42057730Profiling of methyltransferases and other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry (CCMS).
Q48338246Promoted Interaction of C/EBPα with Demethylated Cxcr3 Gene Promoter Contributes to Neuropathic Pain in Mice
Q28829460Prostate cancer epigenetics and its clinical implications
Q38053799Protein and nucleic acid methylating enzymes: mechanisms and regulation
Q51387869Rapid restriction enzyme free detection of DNA methyltransferase activity based on DNA-templated silver nanoclusters.
Q38346032Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking.
Q33599015Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer
Q39101539Reconsolidation and extinction: Using epigenetic signatures to challenge conventional wisdom
Q36428635Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome
Q24536144Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
Q39427597Relationship between aberrant methylation of FAS promoter and biological behavior of bladder urothelial carcinoma
Q36459959Role of DNA methyltransferases in regulation of human ribosomal RNA gene transcription
Q36459023Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression
Q38625953SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases
Q44784397Sequence-specific methyltransferase-induced labeling of DNA (SMILing DNA).
Q46182968Simultaneous DNA binding, bending, and base flipping: evidence for a novel M.EcoRI methyltransferase-DNA complex
Q44359947Specific conjugation of DNA binding proteins to DNA templates through thiol-disulfide exchange
Q44462159Speculations about alternative DNA structures
Q85192990Structural Stability of Tandemly Occurring Noncanonical Basepairs within Double Helical Fragments: Molecular Dynamics Studies of Functional RNA
Q27657231Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2
Q34318368Structure analysis of Entamoeba histolytica DNMT2 (EhMeth).
Q51608273Structure and dynamics of H. pylori 98-10 C5-cytosine specific DNA methyltransferase in complex with S-adenosyl-l-methionine and DNA.
Q27641920Structure and dynamics of hemimethylated GATC sites: implications for DNA-SeqA recognition
Q37829700Structure and function of mammalian DNA methyltransferases.
Q37168010Structure and substrate recognition of the Escherichia coli DNA adenine methyltransferase
Q36598928Structure, function and mechanism of exocyclic DNA methyltransferases
Q27641151Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding
Q33290797Study of bacteriophage T4-encoded Dam DNA (adenine-N6)-methyltransferase binding with substrates by rapid laser UV cross-linking.
Q42813787Studying epigenetic DNA modifications in undergraduate laboratories using complementary bioinformatic and molecular approaches
Q35900625Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates
Q64066991Switching transcription with bacterial RNA polymerase through photocaging, photorelease and phosphorylation reactions in the major groove of DNA
Q37346268Symmetry elements in DNA structure important for recognition/methylation by DNA [amino]-methyltransferases
Q39023383Targeted mutagenesis results in an activation of DNA methyltransferase 1 and confirms an autoinhibitory role of its RFTS domain
Q90429907Targeting DNA Hypomethylation in Malignancy by Epigenetic Therapies
Q59329522Targets and genomic constraints of ectopic Dnmt3b expression
Q39818109The C-terminal domain of the Arabidopsis AtMBD7 protein confers strong chromatin binding activity
Q37934241The Caulobacter crescentus DNA-(adenine-N6)-methyltransferase CcrM methylates DNA in a distributive manner.
Q50192087The DNA Methylome of the Hyperthermoacidophilic Crenarchaeon Sulfolobus acidocaldarius
Q95933791The DNA methylation landscape of giant viruses
Q34344734The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites
Q40164034The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu
Q38287903The Escherichia coli dam DNA methyltransferase modifies DNA in a highly processive reaction
Q50872303The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site.
Q28484739The N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase PrmC/HemK in Chlamydia trachomatis methylates class 1 release factors
Q64984421The Role of Abnormal Methylation of Wnt5a Gene Promoter Regions in Human Epithelial Ovarian Cancer: A Clinical and Experimental Study.
Q64941956The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis.
Q37911496The application of delivery systems for DNA methyltransferase inhibitors
Q21146716The chloroplast genomes of Bryopsis plumosa and Tydemania expeditiones (Bryopsidales, Chlorophyta): compact genomes and genes of bacterial origin
Q64254964The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori
Q34599812The fetal origins of memory: the role of dietary choline in optimal brain development
Q37680400The functions of DNA methylation by CcrM in Caulobacter crescentus: a global approach
Q34204135The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.
Q33879044The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols.
Q47307349The non-specific adenine DNA methyltransferase M.EcoGII.
Q38015454The nutrigenetics and nutrigenomics of the dietary requirement for choline
Q53432255The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.
Q35281331The supply of choline is important for fetal progenitor cells
Q34977098The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC)
Q26865951To be or not to be: regulation of restriction-modification systems and other toxin-antitoxin systems
Q50239553Tomato MBD5, a methyl CpG binding domain protein, physically interacting with UV-damaged DNA binding protein-1, functions in multiple processes
Q46446995Towards an understanding of DNA recognition by the methyl-CpG binding domain 1.
Q40468517Up-regulation of DNA methyltransferase 3B expression in endometrial cancers.
Q45826233miR-370 is stage-specifically expressed during mouse embryonic development and regulates Dnmt3a

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