Claudins and the modulation of tight junction permeability

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Claudins and the modulation of tight junction permeability is …
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scholarly articleQ13442814

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P356DOI10.1152/PHYSREV.00019.2012
P932PMC publication ID3768107
P698PubMed publication ID23589827
P5875ResearchGate publication ID236186409

P50authorDorothee GünzelQ47087623
P2093author name stringAlan S L Yu
P2860cites workThe claudin gene family: expression in normal and neoplastic tissuesQ21260426
Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the ClaudinsQ21266638
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strandsQ22008687
Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorptionQ22010191
Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctionsQ22010607
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotypeQ22122487
The local differentiation of myelinated axons at nodes of RanvierQ22337224
Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal diseaseQ24301628
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cellsQ24302552
Claudin-14 regulates renal Ca⁺⁺ transport in response to CaSR signalling via a novel microRNA pathwayQ24306467
Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivoQ24318656
A novel claudin 16 mutation associated with childhood hypercalciuria abolishes binding to ZO-1 and results in lysosomal mistargetingQ24532149
Cation selective glass electrodes and their mode of operationQ24538725
Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16Q24544268
claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicingQ24548291
Three types of gap junctions interconnecting intestinal epithelial cells visualized by freeze-etchingQ24563056
MUSCLE: multiple sequence alignment with high accuracy and high throughputQ24613456
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudinsQ24633640
PROSITE, a protein domain database for functional characterization and annotationQ24644916
Smad7 induces hepatic metastasis in colorectal cancerQ24649660
Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvementQ24672137
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complexQ24673684
Pheromone-regulated genes required for yeast mating differentiationQ24678064
Claudin-6 and claudin-9 function as additional coreceptors for hepatitis C virusQ24681592
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudinsQ24682136
Renal Na-reabsorption and O2-uptake in dogs during hypoxia and hydrochlorothiazide infusionQ79081741
Expression patterns of claudin family of tight-junction proteins in the mouse prostateQ79680779
Distinct claudin expression profile in histologic subtypes of lung cancerQ80121843
Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humansQ80165877
Transgenic RNAi depletion of claudin-16 and the renal handling of magnesiumQ80177883
Claudin-based permeability barriers in taste budsQ80189250
Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitisQ80362362
Renal dysplasia unrelated to claudin-16 deficiency in Japanese Black cattleQ80404493
The CLDN5 locus may be involved in the vulnerability to schizophreniaQ80555325
The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stabilityQ80561465
Megaintestine in claudin-15-deficient miceQ80612306
WNK4 phosphorylates ser(206) of claudin-7 and promotes paracellular Cl(-) permeabilityQ80671008
Regulation of heterotypic claudin compatibilityQ80797514
Osteoblasts express claudins and tight junction-associated proteinsQ80951780
Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistanceQ81431809
SnapShot: tight and adherens junction signalingQ81460005
Abnormal development of nephrons in claudin-16-defective Japanese black cattleQ81483453
Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patternsQ82468003
TNF-alpha induced NFκB signaling and p65 (RelA) overexpression repress Cldn5 promoter in mouse brain endothelial cellsQ82789631
Endothelial tight junctions: permeable barriers of the vessel wallQ82860964
Permeability properties of the teleost gill epithelium under ion-poor conditionsQ83149566
A weak association of the CLDN5 locus with schizophrenia in Chinese case-control samplesQ84186317
Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small IntestineQ84779796
Cloning and characterization of the murine claudin-5 promoter.Q42444579
Novel expression of claudin-5 in glomerular podocytes.Q42483098
ATP depletion: a novel method to study junctional properties in epithelial tissues. I. Rearrangement of the actin cytoskeleton.Q42484467
Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouseQ42490464
Heterogeneity in expression and subcellular localization of tight junction proteins, claudin-10 and -15, examined by RT-PCR and immunofluorescence microscopyQ42491417
Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin-4.Q30882635
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's diseaseQ33249005
Transcriptomic approach to the study of osmoregulation in the European eel Anguilla anguillaQ33292640
A claudin-9-based ion permeability barrier is essential for hearing.Q33495556
Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activationQ33556277
Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxinQ33557833
A new function for parietal epithelial cells: a second glomerular barrierQ33570054
Renal salt wasting and chronic dehydration in claudin-7-deficient miceQ33589127
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriersQ33590480
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivityQ33782512
The peripheral myelin protein 22 and epithelial membrane protein familyQ33851812
Claudin and occludin expression and function in the seminiferous epitheliumQ33857009
Mutations in the gene encoding tight junction claudin-14 cause autosomal recessive deafness DFNB29.Q33932144
Everything you wanted to know about the bladder epithelium but were afraid to ask.Q33932620
Minimal effects of VEGF and anti-VEGF drugs on the permeability or selectivity of RPE tight junctions.Q33938278
Expression and phylogeny of claudins in vertebrate primordiaQ33943052
Ouabain modulates epithelial cell tight junction.Q33952894
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degenerationQ33967701
The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control.Q34007920
Developmental changes in rabbit proximal straight tubule paracellular permeabilityQ34019052
Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteinsQ34041051
Altered expression of tight junction proteins in mammary epithelium after discontinued suckling in miceQ34041206
Fracture faces of zonulae occludentes from "tight" and "leaky" epitheliaQ34051800
Fine structural localization of a blood-brain barrier to exogenous peroxidaseQ34054533
The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate receptor trafficking regulator "stargazin" is related to the claudin family of proteins by Its ability to mediate cell-cell adhesionQ34081801
Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesisQ34117451
Claudins create charge-selective channels in the paracellular pathway between epithelial cellsQ34132571
Androgens regulate the permeability of the blood-testis barrierQ34133262
Double gene deletion reveals lack of cooperation between claudin 11 and claudin 14 tight junction proteins.Q34148005
Visualization and quantitative analysis of reconstituted tight junctions using localization microscopyQ34154737
Wide nanoscopic pore of maxi-anion channel suits its function as an ATP-conductive pathwayQ34187024
A dual-pathway ultrastructural model for the tight junction of rat proximal tubule epitheliumQ34187664
A model of tight junction function in central nervous system myelinated axonsQ34215442
FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammationQ37393706
Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function.Q37404731
Structure-function studies of claudin extracellular domains by cysteine-scanning mutagenesis.Q37431293
Transforming growth factor-beta signaling alters substrate permeability and tight junction protein expression at the blood-brain barrier during inflammatory painQ37543496
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertensionQ37571326
Cation permeation mechanisms and cation selectivity in "tight junctions" of gallbladder epitheliumQ37625153
Claudin Family of Proteins and Cancer: An OverviewQ37776656
Occludin protein family: oxidative stress and reducing conditionsQ37828522
Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexesQ37856395
Junctions gone bad: claudins and loss of the barrier in cancerQ37868338
Claudin family proteins in Caenorhabditis elegansQ37895994
Claudins and other tight junction proteinsQ38110750
The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiationQ38319668
Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axisQ38328111
Localization of the receptor-binding region of Clostridium perfringens enterotoxin utilizing cloned toxin fragments and synthetic peptides. The 30 C-terminal amino acids define a functional binding regionQ38334803
Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctionsQ38343058
Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivoQ38407509
Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epitheliumQ38417912
Developmental profile of claudin-3, -5, and -16 proteins in the epithelium of chick intestine.Q38431276
Na+ transport by rabbit urinary bladder, a tight epitheliumQ39113928
Specialized junction in the distal convoluted tubule of rat kidneyQ39384363
The ubiquitin-proteasome pathway regulates claudin 5 degradationQ39385931
Suppression of the epithelial-mesenchymal transition by Grainyhead-like-2.Q39387840
Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudinsQ39435494
Claudin-1 involved in neonatal ichthyosis sclerosing cholangitis syndrome regulates hepatic paracellular permeabilityQ39452140
Mammalian blastocyst: transport functions in a developing epitheliumQ39531730
Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cellsQ39593586
Perspectives on tight junction researchQ39607231
TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signalingQ39634008
Rab5a-mediated localization of claudin-1 is regulated by proteasomes in endothelial cellsQ39647501
Expression of Claudin-2 in intestinal metaplastic mucosa of Cdx2-transgenic mouse stomach.Q39684300
Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large moleculesQ39723716
The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heterotypic claudin compatibilityQ39734445
Smad signaling is required to maintain epigenetic silencing during breast cancer progression.Q39750283
Extracellular Mg(2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylationQ39774560
Claudin-16 affects transcellular Cl- secretion in MDCK cellsQ39837634
Variations in tight and gap junctions in mammalian tissuesQ24682450
Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludinQ24682664
Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cellsQ24682677
Manner of interaction of heterogeneous claudin species within and between tight junction strandsQ24683327
Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxinQ24683859
Claudin 7 expression and localization in the normal murine mammary gland and murine mammary tumorsQ24797711
Residues in a Highly Conserved Claudin-1 Motif Are Required for Hepatitis C Virus Entry and Mediate the Formation of Cell-Cell ContactsQ27488396
Structure of the claudin-binding domain of Clostridium perfringens enterotoxinQ27648943
Crystal Structure of Clostridium perfringens Enterotoxin Displays Features of  -Pore-forming ToxinsQ27667501
Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming ToxinsQ27671708
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomesQ27860838
The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation.Q27934265
The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicansQ27939681
Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane proteinQ28141954
Role of claudin interactions in airway tight junctional permeabilityQ28156383
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by SnailQ28187811
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architectureQ28191564
Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epitheliumQ28201574
CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene familyQ28203114
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion moleculeQ28203316
Size-selective loosening of the blood-brain barrier in claudin-5-deficient miceQ28203769
Regulation of the Expression of the Prostate-specific Antigen by Claudin-7Q28204178
Organization and formation of the tight junction system in human epidermis and cultured keratinocytesQ28204743
Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segmentsQ28209952
Multifunctional strands in tight junctionsQ28210051
Permeability barrier dysfunction in transgenic mice overexpressing claudin 6Q28211420
Cloning of the human claudin-2 5'-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alphaQ28212968
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cellsQ28214827
Expression patterns of claudins, tight junction adhesion molecules, in the inner earQ28236557
Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activityQ28241499
Renal magnesium handling and its hormonal controlQ28252710
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epitheliumQ28255146
The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulationQ28255715
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudinsQ34234275
Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localizationQ34241219
Claudin-17 forms tight junction channels with distinct anion selectivityQ34259746
Calcium inhibits paracellular sodium conductance through claudin-2 by competitive bindingQ34299341
Nucleofection disrupts tight junction fence function to alter membrane polarity of renal epithelial cellsQ34305517
Palmitoylation of claudins is required for efficient tight-junction localizationQ34403266
Paracellin-1 and the modulation of ion selectivity of tight junctionsQ34460832
Dysregulation of claudin-5 in HIV-induced interstitial pneumonitis and lung vascular injury. Protective role of peroxisome proliferator-activated receptor-γ.Q34480264
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.Q34546258
Structure and function of claudins.Q34585322
Tight junction defects in patients with atopic dermatitis.Q34629278
A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progressionQ34639345
Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiencyQ34652895
The cytoplasmic plaque of tight junctions: a scaffolding and signalling centerQ34761497
PPARgamma-regulated tight junction development during human urothelial cytodifferentiationQ34863027
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of SnailQ34972866
Claudin-19 and the barrier properties of the human retinal pigment epitheliumQ35005857
A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cellsQ35083404
Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier functionQ35087018
Elucidating the principles of the molecular organization of heteropolymeric tight junction strands.Q35107926
Claudin-4 levels are associated with intact alveolar fluid clearance in human lungsQ35167870
Chitinases in the salivary glands and circulation of patients with Sjögren's syndrome: macrophage harbingers of disease severityQ35242525
Extensive expansion of the claudin gene family in the teleost fish, Fugu rubripesQ35574015
MicroRNA-204/211 alters epithelial physiologyQ35595622
Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans.Q35628297
Inflammation and disruption of the mucosal architecture in claudin-7-deficient miceQ35705366
Analysis of Snail-1, E-cadherin and claudin-1 expression in colorectal adenomas and carcinomasQ35795767
Setting up a selective barrier at the apical junction complexQ35804794
Lipid polarity is maintained in absence of tight junctionsQ35841899
Functional characterization and localization of a gill-specific claudin isoform in Atlantic salmonQ35950310
The molecular physiology of tight junction poresQ35952151
The ultrastructural basis of capillary permeability studied with peroxidase as a tracerQ36188502
Deafness in Claudin 11-null mice reveals the critical contribution of basal cell tight junctions to stria vascularis function.Q36191433
Localization of permeability barriers in the frog skin epitheliumQ36192783
Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymisQ42508036
Identification and subcellular localization of paracellin-1 (claudin-16) in human salivary glandsQ42513671
Claudin-6 localized in tight junctions of rat podocytesQ42526089
The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cellsQ42570947
Claudin-1 required for HCV virus entry has high potential for phosphorylation and O-glycosylationQ42759235
A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblastsQ42796669
Cholesterol depletion alters detergent-specific solubility profiles of selected tight junction proteins and the phosphorylation of occludinQ42910922
Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutesQ42960019
Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.Q42985802
PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cellsQ43130621
Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosisQ43150819
Morphological factors influencing transepithelial conductance in a rabbit model of ileitisQ43522978
Claudin-2 is selectively expressed in proximal nephron in mouse kidneyQ43761068
Morphological factors influencing transepithelial permeability: A model for the resistance of theZonula OccludensQ43798217
Tight and gap junctions in the intestinal tract of tunicates (Urochordata): a freeze-fracture studyQ44129427
Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cellsQ44183308
A freeze-fracture study of the junctions between glomerular epithelial cells in aminonucleoside nephrosisQ44222726
Heterogeneity of claudin expression by alveolar epithelial cellsQ44324565
Establishment of tight junctions between cells from different animal species and different sealing capacitiesQ44556091
Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier.Q44612383
Expression of claudin-7 and -8 along the mouse nephron.Q44726960
Salinity regulates claudin mRNA and protein expression in the teleost gill.Q44872574
IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathwaysQ45046111
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.Q45345068
The tetraspan protein Dni1p is required for correct membrane organization and cell wall remodelling during mating in Schizosaccharomyces pombe.Q45922037
Cysteine mutagenesis to study the structure of claudin-2 paracellular pores.Q45963238
Kidney oxygen consumption, carbonic anhydrase, and proton secretionQ46149916
Junctions in developing human and rat kidney: a freeze-fracture studyQ46171860
Genetic control of single lumen formation in the zebrafish gut.Q46213345
Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patientsQ46308412
The mechanism of cation permeation in rabbit gallbladder : Conductances, the current-voltage relation, the concentration dependence of anion-cation discrimination, and the calcium competition effectQ46460870
Overexpression of claudin-7 decreases the paracellular Cl- conductance and increases the paracellular Na+ conductance in LLC-PK1 cellsQ46520833
Effects of PPAR agonists on proliferation and differentiation in human urotheliumQ46525079
Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cellsQ46639019
Polymorphic assemblies and crystalline arrays of lens tetraspanin MP20.Q46827716
The mechanism of cation permeation in rabbit gallbladder : Dilution potentials and biionic potentialsQ46932771
The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila.Q47072676
Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28.Q47073283
Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptidesQ47289212
Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and sizeQ47301250
Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamilyQ47306972
Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular poresQ47608346
A deletion of the paracellin-1 gene is responsible for renal tubular dysplasia in cattle.Q47828156
Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiformeQ47929273
Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function.Q47968175
Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathwaysQ48168395
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.Q48404601
Claudin-1, claudin-2 and claudin-11 are present in tight junctions of choroid plexus epithelium of the mouseQ48828901
SUMOylation of claudin-2Q28269524
PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cellsQ28269640
The C-terminal cytoplasmic tail of claudins 1 and 5 but not its PDZ-binding motif is required for apical localization at epithelial and endothelial tight junctionsQ28272619
Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubulesQ28279525
Claudin-2, a component of the tight junction, forms a paracellular water channelQ28282138
Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cellsQ28284028
Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeabilityQ28365900
Sp1 site is crucial for the mouse claudin-19 gene expression in the kidney cellsQ28504768
Molecular staging of epithelial maturation using secretory cell-specific genes as markersQ28505936
Distinct subdomain organization and molecular composition of a tight junction with adherens junction featuresQ28506754
Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestineQ28509306
CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null miceQ28512612
Predicted expansion of the claudin multigene familyQ28513418
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient miceQ28513737
Claudin-7 regulates EpCAM-mediated functions in tumor progressionQ28566627
Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cellsQ28569839
Association of paracellin-1 with ZO-1 augments the reabsorption of divalent cations in renal epithelial cellsQ28569896
Slit diaphragms contain tight junction proteinsQ28573180
Functional analysis for peripheral myelin protein PASII/PMP22: is it a member of claudin superfamily?Q28574326
Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase CQ28577565
Primary gene structure and expression studies of rodent paracellin-1Q28578968
Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemiaQ28579928
Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gutQ28581268
Tissue-specific expression of the tight junction proteins claudins and occludin in the rat salivary glandsQ28581494
Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alphaQ28583194
Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiationQ28589537
The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family membersQ28589786
The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complexQ28591754
Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient miceQ28592632
The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancerQ28743642
ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) geneQ28771716
Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral densityQ28943501
Claudin association with CD81 defines hepatitis C virus entry.Q29465808
Junctional complexes in various epitheliaQ29620435
Identification of new claudin family members by a novel PSI-BLAST based approach with enhanced specificity.Q30357239
Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3.Q39853561
Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cellsQ39857843
The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells.Q39871522
Smad4 restoration leads to a suppression of Wnt/beta-catenin signaling activity and migration capacity in human colon carcinoma cellsQ39873345
Na+ absorption defends from paracellular back-leakage by claudin-8 upregulationQ39919057
Enhancement of barrier function by overexpression of claudin-4 in tight junctions of submandibular gland cells.Q39929371
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell lineQ39940922
Oxidative stress induces gastric epithelial permeability through claudin-3.Q39942782
Tight and leaky junctions of epithelia: a perspective on kisses in the dark.Q39948332
Snail-associated epithelial-mesenchymal transition promotes oesophageal squamous cell carcinoma motility and progression.Q39980438
Selective decrease in paracellular conductance of tight junctions: role of the first extracellular domain of claudin-5.Q39998597
Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinomaQ40016296
Activation of RON differentially regulates claudin expression and localization: role of claudin-1 in RON-mediated epithelial cell motilityQ40023313
The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.Q40024709
Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16.Q40058720
Formation of tight junction: determinants of homophilic interaction between classic claudins.Q40087090
A novel cysteine cross-linking method reveals a direct association between claudin-1 and tetraspanin CD9.Q40103786
Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2.Q40129999
The first extracellular domain of claudin-7 affects paracellular Cl- permeabilityQ40151357
Renal localization and function of the tight junction protein, claudin-19.Q40153685
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architectureQ40156403
Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cellsQ40169681
Activation of an SP binding site is crucial for the expression of claudin 1 in rat epididymal principal cellsQ40179374
Dual transcriptional control of claudin-11 via an overlapping GATA/NF-Y motif: positive regulation through the interaction of GATA, NF-YA, and CREB and negative regulation through the interaction of Smad, HDAC1, and mSin3A.Q40182771
PDZ domain binding selectivity is optimized across the mouse proteomeQ40191457
Study of claudin function by RNA interferenceQ40224183
Exogenous expression of claudin-5 induces barrier properties in cultured rat brain capillary endothelial cellsQ40228071
Paracellular ion channel at the tight junctionQ40231113
TRPV4-mediated regulation of epithelial permeabilityQ40238454
Two splice variants of claudin-10 in the kidney create paracellular pores with different ion selectivities.Q40262405
On tight-junction structureQ40264285
Crucial roles of Sp1 and epigenetic modifications in the regulation of the CLDN4 promoter in ovarian cancer cellsQ40277231
Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctionsQ40293770
On the self-association potential of transmembrane tight junction proteins.Q40321024
Claudin-8 modulates paracellular permeability to acidic and basic ions in MDCK II cellsQ40345251
EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeabilityQ40360123
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells.Q40360748
Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarizationQ40385830
Modulation of epithelial morphology, monolayer permeability, and cell migration by growth arrest specific 3/peripheral myelin protein 22Q40474179
Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP.Q40512823
Ochratoxin A increases permeability through tight junctions by removal of specific claudin isoformsQ40540029
Sequence and Phylogenetic Analyses of 4 TMS Junctional Proteins of Animals: Connexins, Innexins, Claudins and OccludinsQ40560997
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeationQ40666802
Leukocyte diapedesis in vivo induces transient loss of tight junction protein at the blood-retina barrier.Q40742606
Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomersQ40794057
Inducible expression of claudin-1-myc but not occludin-VSV-G results in aberrant tight junction strand formation in MDCK cellsQ40855515
Uncoupling of gate and fence functions of MDCK cells by the actin-depolymerizing reagent mycalolide B.Q40876165
Claudin-1 contributes to the epithelial barrier function in MDCK cellsQ40900841
Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.Q40925316
Permeability of Sertoli cell tight junctions to lanthanum after ligation of ductus deferens and ductuli efferentesQ41175940
Polarized monolayers formed by epithelial cells on a permeable and translucent supportQ41233493
Definitive evidence for the existence of tight junctions in invertebratesQ41273618
Differential expression of claudin tight junction proteins in the human cortical nephronQ41436529
An anastomosing septate junction in endothelial cells of the phylum echinodermataQ41692678
NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endotheliaQ41976595
Differentiation of epithelial foot processes and filtration slits: sequential appearance of occluding junctions, epithelial polyanion, and slit membranes in developing glomeruliQ41998669
Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testisQ42079092
Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transitionQ42126608
Cell junctions in amphioxus (Cephalochordata): a thin section and freeze-fracture study.Q42438551
Zonulae occludentes in junctional complex-enriched fractions from mouse liver: preliminary morphological and biochemical characterizationQ36210591
Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytesQ36210944
Occluding junction structure-function relationships in a cultured epithelial monolayerQ36213963
Tight junction structure and ZO-1 content are identical in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistanceQ36221153
Mammalian tight junctions in the regulation of epithelial differentiation and proliferationQ36228546
Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cellsQ36316586
Twenty-first Bowditch lecture. The epithelial junction: bridge, gate, and fenceQ36320057
Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size controlQ36322348
Claudin-16 and claudin-19 interact and form a cation-selective tight junction complexQ36330886
Ionic conductances of extracellular shunt pathway in rabbit ileum. Influence of shunt on transmural sodium transport and electrical potential differencesQ36387771
Tight junctions: molecular architecture and functionQ36400271
Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomesQ36452928
Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.Q36559702
Surface charges and ion channel functionQ36653548
A missense mutation in LIM2 causes autosomal recessive congenital cataractQ36741962
Establishment of conditionally immortalized mouse glomerular parietal epithelial cells in cultureQ36906027
Effect of claudins 6 and 9 on paracellular permeability in MDCK II cellsQ36977167
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformationQ36982054
Tight junctions potentiate the insulative properties of small CNS myelinated axons.Q36993394
Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction siteQ37023274
Claudin-1, -2, -3, -4, -7, -8, and -10 protein expression in biliary tract cancersQ37066104
Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins.Q37096352
Regulation of endothelial junctional permeabilityQ37122803
PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cellsQ37136037
Genetic targeting of the endoderm with claudin-6CreER.Q37149837
Function and regulation of claudins in the thick ascending limb of HenleQ37151668
A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transitionQ37162704
Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brainsQ37294353
Tight junction proteins expression and modulation in immune cells and multiple sclerosisQ37294615
Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesiumQ37340830
Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injuryQ37343892
The claudinsQ37350823
Age-related changes of claudin expression in mouse liver, kidney, and pancreas.Q37381530
Claudin-2 forms homodimers and is a component of a high molecular weight protein complexQ30428439
Distribution of tight junction proteins in adult human salivary glands.Q30437791
Dynamic behavior of paired claudin strands within apposing plasma membranesQ30477728
The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating.Q30478914
Functional and comparative genomics analyses of pmp22 in medaka fishQ30488983
Reciprocal regulation of the junctional proteins claudin-1 and connexin43 by interleukin-1beta in primary human fetal astrocytesQ73221704
Paracellular channels!Q78069138
Renal sodium transport and oxygen consumptionQ79045044
Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1.Q48910439
Tight junction proteins in gallbladder epithelium: different expression in acute acalculous and calculous cholecystitisQ50162449
Claudin-3 tight junction proteins in Tetraodon nigroviridis: cloning, tissue-specific expression, and a role in hydromineral balance.Q50642093
Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos.Q51973279
Segment-specific expression of tight junction proteins, claudin-2 and -10, in the rat epididymal epithelium.Q52034651
Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland.Q52087577
Septate and paranodal junctions: kissing cousinsQ52098781
Ionic selectivity of the paracellular shunt path across rabbit corneal endothelium.Q52433725
The contribution of a chloride shunt to the transmucosal potential of the rabbit submaxillary ductQ52439272
Transforming growth factor beta3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway.Q52549524
Microelectrode assessment of chloride-conductive properties of cortical collecting duct.Q52690943
Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting.Q52905611
Claudin function in the thick ascending limb of Henle's loop.Q52910396
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: blocking endocytosis restores surface expression of a novel Claudin-16 mutant that lacks the entire C-terminal cytosolic tail.Q52934417
Role of post translational modifications and novel crosstalk between phosphorylation and O-beta-GlcNAc modifications in human claudin-1, -3 and -4.Q53159348
Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours.Q53264168
mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting.Q53519195
Route of passive ion permeation in epithelia.Q53761580
Further observations on the fine structure of freeze-cleaved tight junctions.Q53816155
Epithelial remodeling and claudin mRNA abundance in the gill and kidney of puffer fish (Tetraodon biocellatus) acclimated to altered environmental ion levels.Q54404981
Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.Q54446299
Tight junction transmembrane protein claudin subtype expression and distribution in human corneal and conjunctival epithelium.Q54500785
Pronase Effect on Pancreatic Beta Cell Secretion and MorphologyQ54787188
Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme.Q55475234
Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction diseaseQ55671093
Transforming Growth Factor-β, a Whey Protein Component, Strengthens the Intestinal Barrier by Upregulating Claudin-4 in HT-29/B6 CellsQ56972147
Mechanisms of diarrhea in collagenous colitisQ56972206
The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the nextQ57075871
Kinetics of Adhesion Mediated by Extracellular Loops of Claudin-2 as Revealed by Single-Molecule Force SpectroscopyQ58186370
Probing effects of pH change on dynamic response of Claudin-2 mediated adhesion using single molecule force spectroscopyQ58186380
Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in MiceQ58363144
Evidence for the lipidic nature of tight junction strandsQ59087871
Uncoupling of the molecular 'fence' and paracellular 'gate' functions in epithelial tight junctionsQ59096636
Altered claudin expression is a feature of chronic plaque psoriasisQ60042083
Transmembrane proteins of tight junctionsQ61050779
Claudin-7 protein differentiates canine cholangiocarcinoma from hepatocellular carcinomaQ62091633
Expression of Claudin-1, -2, -3, -4, -5 and -7 Proteins in Benign and Malignant Canine Mammary Gland Epithelial TumoursQ62091645
Evidence of a paracellular pathway for ion flow in the kidney proximal tubule: Electromicroscopic demonstration of lanthanum precipitate in the tight junctionQ67252541
Intercellular junctions in podocytes of the nephrotic glomerulus as seen with freeze-fractureQ67255730
Alterations of the glomerular epithelium in acute aminonucleoside nephrosis. Evidence for formation of occluding junctions and epithelial cell detachmentQ67741148
On tight junction structure: Forssman glycolipid does not flow between MDCK cells in an intact epithelial monolayerQ69609267
Cation selectivity of the isolated perfused cortical thick ascending limb of Henle's loop of rabbit kidneyQ70663979
Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins. Application to the immunogold labeling of intercellular junctional complexesQ70964707
Septate junctions with paired septa in the cephalochordate Branchiostoma lanceolatumQ71681674
Effects of osmotic diuresis on sodium reabsorption and oxygen consumption of kidneyQ72768660
Energy requirement for sodium reabsorption in the in vivo rabbit kidneyQ72822588
Oxygen requirement of bicarbonate-dependent sodium reabsorption in the dog kidneyQ72848275
Altered molecular architecture of peripheral nerves in mice lacking the peripheral myelin protein 22 or connexin32Q73182629
P433issue2
P304page(s)525-569
P577publication date2013-04-01
P1433published inPhysiological ReviewsQ1091827
P1476titleClaudins and the modulation of tight junction permeability
P478volume93

Reverse relations

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Q61805685Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation
Q39277299Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function
Q39206409Hypoxic Stress and Inflammatory Pain Disrupt Blood-Brain Barrier Tight Junctions: Implications for Drug Delivery to the Central Nervous System
Q47758483IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression.
Q91809872IL-22-binding protein exacerbates influenza, bacterial super-infection
Q41601556Identification and dynamic regulation of tight junction protein expression in human neural stem cells.
Q92003046Identification of a missense variant in CLDN2 in obstructive azoospermia
Q92618333Identification of claudin-2, -6, -11 and -14 as prognostic markers in human breast carcinoma
Q92208628Identification of claudin‑1, ‑3, ‑7 and ‑8 as prognostic markers in human laryngeal carcinoma
Q38825792Identification of the septate junction protein gliotactin in the mosquito Aedes aegypti: evidence for a role in increased paracellular permeability in larvae
Q42247910Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain
Q64118955Impact of Sensitization and Inflammation on the Interaction of Mast Cells With the Intestinal Epithelium in Rats
Q38871793Impaired Barrier Function and Autoantibody Generation in Malnutrition Enteropathy in Zambia
Q35048607Improved cell line IPEC-J2, characterized as a model for porcine jejunal epithelium
Q55339614Inactivation of the tight junction gene CLDN11 by aberrant hypermethylation modulates tubulins polymerization and promotes cell migration in nasopharyngeal carcinoma.
Q36382104Increased urothelial paracellular transport promotes cystitis
Q38902578Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
Q89849213Influence of Endogenous Cardiac Glycosides, Digoxin, and Marinobufagenin in the Physiology of Epithelial Cells
Q39876293Insights into the C-terminal Peptide Binding Specificity of the PDZ Domain of Neuronal Nitric-oxide Synthase: CHARACTERIZATION OF THE INTERACTION WITH THE TIGHT JUNCTION PROTEIN CLAUDIN-3.
Q38715954Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner
Q38654939Integrative physiology of transcellular and paracellular intestinal absorption.
Q91817121Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture
Q90369222Intestinal Barrier Function in Chronic Kidney Disease
Q90460272Intestinal Barrier Function in Gluten-Related Disorders
Q92619274Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
Q38460376Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
Q50600432Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice.
Q91650386Intestine-Liver Axis On-Chip Reveals the Intestinal Protective Role on Hepatic Damage by Emulating Ethanol First-Pass Metabolism
Q36812374Junctional proteins of the blood-brain barrier: New insights into function and dysfunction
Q57488950Knockdown of CLDN6 inhibits cell proliferation and migration via PI3K/AKT/mTOR signaling pathway in endometrial carcinoma cell line HEC-1-B
Q28590804LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation
Q99237888Lactobacillus johnsonii BS15 Prevents Psychological Stress-Induced Memory Dysfunction in Mice by Modulating the Gut-Brain Axis
Q35122097Laurate permeabilizes the paracellular pathway for small molecules in the intestinal epithelial cell model HT-29/B6 via opening the tight junctions by reversible relocation of claudin-5. [Corrected].
Q37377308Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines
Q43246481Low molecular weight components of pollen alter bronchial epithelial barrier functions.
Q47413203Lysophosphatidic Acid Receptor 1 Is Important for Intestinal Epithelial Barrier Function and Susceptibility to Colitis
Q47214679Magnesium homeostasis in cattle: absorption and excretion
Q49171448Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types.
Q90626670Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells
Q51732421Maternal High-Fat and High-Salt Diets Have Differential Programming Effects on Metabolism in Adult Male Rat Offspring.
Q36904216Mechanisms Underlying Adaptation to Life in Hydrogen Sulfide-Rich Environments
Q58774497Mechanisms regulating intestinal barrier integrity and its pathological implications
Q36325889Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins
Q39339639Mend Your Fences: The Epithelial Barrier and its Relationship With Mucosal Immunity in Inflammatory Bowel Disease
Q29048401Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells
Q90469795Metformin Improves Fertility in Obese Males by Alleviating Oxidative Stress-Induced Blood-Testis Barrier Damage
Q38662791Methionine restriction fundamentally supports health by tightening epithelial barriers
Q36982325MicroRNA-142-5p contributes to Hashimoto's thyroiditis by targeting CLDN1
Q47395797Missense mutation at CLDN8 associated with a high plasma interferon gamma-inducible protein 10 level in methadone-maintained patients with urine test positive for morphine
Q92889701Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression
Q48573176Molecular and structural transmembrane determinants critical for embedding claudin-5 into tight junctions reveal a distinct four-helix bundle arrangement
Q89143916Molecular determination of claudin-15 organization and channel selectivity
Q64252834Morphologic determinant of tight junctions revealed by claudin-3 structures
Q35534090Moxibustion combined with acupuncture increases tight junction protein expression in Crohn's disease patients
Q42695148New therapeutic perspectives in irritable bowel syndrome: Targeting low-grade inflammation, immuno-neuroendocrine axis, motility, secretion and beyond
Q26772345Nutritional Keys for Intestinal Barrier Modulation
Q38618533Occluding junctions of invertebrate epithelia
Q51315381Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats.
Q26738728Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
Q52723966Organic osmolytes preserve the function of the developing tight junction in ultraviolet B-irradiated rat epidermal keratinocytes.
Q33558636Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.
Q42654487P2Y2 receptor knock-out mice display normal NaCl absorption in medullary thick ascending limb
Q37042210Paracellular epithelial sodium transport maximizes energy efficiency in the kidney
Q40234167Paracellular transport as a strategy for energy conservation by multicellular organisms?
Q92356336Particulate matter disrupts airway epithelial barrier via oxidative stress to promote Pseudomonas aeruginosa infection
Q30991035Pasiflora proteins are novel core components of the septate junction
Q56342148Pathophysiology of environmental enteric dysfunction and its impact on oral vaccine efficacy
Q50450544Perfluorooctanoic acid disrupts the blood-testis barrier and activates the TNFα/p38 MAPK signaling pathway in vivo and in vitro.
Q38991918Physiological roles of claudins in kidney tubule paracellular transport
Q51054064Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.
Q37012935Poly(amido amine) dendrimers in oral delivery
Q35672827Polymorphisms in CaSR and CLDN14 Genes Associated with Increased Risk of Kidney Stone Disease in Patients from the Eastern Part of India
Q91754424Postbiotic L. plantarum RG14 improves ruminal epithelium growth, immune status and upregulates the intestinal barrier function in post-weaning lambs
Q36749403Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease
Q47584454Process of tight junction recovery in the injured vocal fold epithelium: Morphological and paracellular permeability analysis.
Q50564347Prolactin and cortisol regulate branchial claudin expression in Japanese medaka.
Q88964866Protein Lipidation in Cell Signaling and Diseases: Function, Regulation, and Therapeutic Opportunities
Q92785707R40.76 binds to the α domain of ZO-1: role of ZO-1 (α+) in epithelial differentiation and mechano-sensing
Q49308998RETRACTED: Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa
Q38978743Redox-sensitive structure and function of the first extracellular loop of the cell-cell contact protein claudin-1: lessons from molecular structure to animals
Q92444704Regional Differences in Tight Junction Protein Expression in the Blood-DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats
Q91994983Regulation of Epithelial Cell Functions by the Osmolality and Hydrostatic Pressure Gradients: A Possible Role of the Tight Junction as a Sensor
Q33559314Regulation of FAK Activity by Tetraspan Proteins: Potential Clinical Implications in Cancer
Q57285991Regulation of epithelial migration by epithelial cell adhesion molecule requires its Claudin-7 interaction domain
Q26776055Regulation of the Intestinal Barrier Function by Host Defense Peptides
Q47351861Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins
Q50116104Relationship between G proteins coupled receptors and tight junctions
Q34442093Renal control of calcium, phosphate, and magnesium homeostasis
Q91656937Rho Flares Repair Local Tight Junction Leaks
Q89175098Rho kinase inhibition maintains intestinal and vascular barrier function by upregulation of occludin in experimental necrotizing enterocolitis
Q48138372Roadblock for antigens--take a detour via M cells.
Q37553595Role of CFTR in epithelial physiology.
Q92155709Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy
Q55555758Role of the Duodenum in the Pathogenesis of Functional Dyspepsia: A Paradigm Shift.
Q41546041Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity
Q41661150SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells
Q37012940Safety concerns over the use of intestinal permeation enhancers: A mini-review
Q39407147Scaffolding proteins in the development and maintenance of the epidermal permeability barrier
Q52882074Significant water absorption goes paracellular in kidney proximal tubules.
Q58777566Silent Witness: Dual-Species Transcriptomics Reveals Epithelial Immunological Quiescence to Helminth Larval Encounter and Fostered Larval Development
Q41571545Sini-san improves duodenal tight junction integrity in a rat model of functional dyspepsia
Q83228100Size control of the inner ear via hydraulic feedback
Q47282467Social stress induces neurovascular pathology promoting depression
Q48248001Sphingosine-1-phosphate (S1P) enhances glomerular endothelial cells activation mediated by anti-myeloperoxidase antibody-positive IgG.
Q38714493Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells
Q91645298Structural Features of Tight-Junction Proteins
Q64065025Structural dynamics of tight junctions modulate the properties of the epithelial barrier
Q47261729Supplementation of oligofructose, but not sucralose, decreases high-fat diet induced body weight gain in mice independent of gustducin-mediated gut hormone release.
Q28271194Systems Proteomics View of the Endogenous Human Claudin Protein Family
Q46115480T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells.
Q38612911TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis.
Q64066738Targeting bacterial quorum sensing shows promise in improving intestinal barrier function following burn‑site infection
Q89771573Teduglutide Promotes Epithelial Tight Junction Pore Function in Murine Short Bowel Syndrome to Alleviate Intestinal Insufficiency
Q58753178The "Frail" Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections
Q89552148The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium
Q33740929The Yin and Yang of bile acid action on tight junctions in a model colonic epithelium
Q47183822The ancient claudin Dni2 facilitates yeast cell fusion by compartmentalizing Dni1 into a membrane subdomain.
Q37302556The claudin family of proteins in human malignancy: a clinical perspective
Q50609805The claudin-16 channel gene is transcriptionally inhibited by 1,25-dihydroxyvitamin D.
Q37607724The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues
Q91704797The effect of different dietary ratios of lysine and arginine in diets with high or low methionine levels on oxidative and epigenetic DNA damage, the gene expression of tight junction proteins and selected metabolic parameters in Clostridium perfrin
Q91272530The effects of neuroblastoma and chemotherapy on metabolism, fecal microbiome, volatile organic compounds, and gut barrier function in a murine model
Q50089510The expression profile of Claudin family members in the developing mouse lung and expression alterations resulting from exposure to secondhand smoke (SHS).
Q40589608The ginger component 6-shogaol prevents TNF-α-induced barrier loss via inhibition of PI3K/Akt and NF-κB signaling
Q35223991The gut microbiota and developmental programming of the testis in mice
Q39376508The inner blood-retinal barrier: Cellular basis and development
Q38811256The interaction of Clostridium perfringens enterotoxin with receptor claudins
Q64092677The kidney anion exchanger 1 affects tight junction properties via claudin-4
Q90499640The mechanobiology of tight junctions
Q41774720The molecular size of the extra-membrane domain influences the diffusion of the GPI-anchored VSG on the trypanosome plasma membrane
Q89763104The multifarious regulation of the apical junctional complex
Q42989738The response of claudin-like transmembrane septate junction proteins to altered environmental ion levels in the larval mosquito Aedes aegypti
Q38223244The role of epithelial tight junctions involved in pathogen infections
Q42372521The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction
Q36601036The role of the calcium-sensing receptor in gastrointestinal inflammation
Q57785309Thick Ascending Limb Sodium Transport in the Pathogenesis of Hypertension
Q89509897Tight Junction Proteins and the Biology of Hepatobiliary Disease
Q40864710Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation.
Q60952879Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals
Q26777540Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier
Q36812411Tight junction modulation of the blood brain barrier: CNS delivery of small molecules
Q57294408Tight junction proteins in gastrointestinal and liver disease
Q36410566Tight junction strand formation by claudin-10 isoforms and claudin-10a/-10b chimeras.
Q58695844Tight junction structure, function, and assessment in the critically ill: a systematic review
Q46779417Tight junctions in Gerbil von Ebner's gland: horseradish peroxidase and freeze-fracture studies
Q39030311Tight junctions in pulmonary epithelia during lung inflammation
Q89699235Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins
Q39363574Tight junctions of the proximal tubule and their channel proteins
Q27697986Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
Q38879992Tight junctions: from simple barriers to multifunctional molecular gates
Q94570149Timekeeping in the hindbrain: a multi-oscillatory circadian centre in the mouse dorsal vagal complex
Q47742901Topographical diversity of common skin microflora and its association with skin environment type: An observational study in Chinese women
Q38719405Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression
Q36592445Transcription, Signaling Receptor Activity, Oxidative Phosphorylation, and Fatty Acid Metabolism Mediate the Presence of Closely Related Species in Distinct Intertidal and Cold-Seep Habitats
Q39388260Transcriptional mechanisms coordinating tight junction assembly during epithelial differentiation.
Q48728454Transcriptional regulation of endothelial-to-mesenchymal transition in cardiac fibrosis: role of myocardin-related transcription factor A and activating transcription factor 3.
Q50892165Transendothelial movement of adiponectin is restricted by glucocorticoids.
Q37579195Transepithelial water and urea permeabilities of isolated perfused Munich-Wistar rat inner medullary thin limbs of Henle's loop
Q93012321Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner
Q90699510Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines
Q37639035Visualizing the dynamic coupling of claudin strands to the actin cytoskeleton through ZO-1.
Q89669036Water amino acid-chelated trace mineral supplementation decreases circulating and intestinal HSP70 and proinflammatory cytokine gene expression in heat-stressed broiler chickens
Q40229014Water and ion permeability of a claudin model: A computational study
Q59333345Wnt Secretion Is Regulated by the Tetraspan Protein HIC-1 through Its Interaction with Neurabin/NAB-1
Q27314931ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape
Q64239829enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA
Q26829455pH-responsive, gluconeogenic renal epithelial LLC-PK1-FBPase+cells: a versatile in vitro model to study renal proximal tubule metabolism and function

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