| scholarly article | Q13442814 |
| P2093 | author name string | Eyal Zcharia | |
| Michael Elkin | |||
| Ruth Atzmon | |||
| Tamar Peretz | |||
| Israel Vlodavsky | |||
| Amichay Meirovitz | |||
| Victoria Doviner | |||
| Ariel M Rubinstein | |||
| Esther Hermano | |||
| Yoav Sherman | |||
| Immanuel Lerner | |||
| Rivka Ishai-Michaeli | |||
| Raanan Bulvik | |||
| Dina Rodkin | |||
| P2860 | cites work | Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis | Q22010222 |
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| High heparanase activity in multiple myeloma is associated with elevated microvessel density | Q75207710 | ||
| Heparanase upregulation by colonic epithelium in inflammatory bowel disease | Q79241944 | ||
| Increased expression of heparanase in overt diabetic nephropathy | Q79272921 | ||
| Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis | Q79906000 | ||
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| Heparanase expression correlates with malignant potential in human colon cancer | Q81213784 | ||
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| Heparan sulfate proteoglycans: intricate molecules with intriguing functions. | Q34310368 | ||
| Promotion of colorectal neoplasia in experimental murine ulcerative colitis | Q34409974 | ||
| The role of COX-2 in intestinal inflammation and colorectal cancer | Q35234704 | ||
| Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation | Q35382754 | ||
| Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis | Q35745865 | ||
| The role of cyclooxygenase 2 in ulcerative colitis-associated neoplasia | Q35829456 | ||
| Angiogenesis blockade as a new therapeutic approach to experimental colitis | Q35953816 | ||
| The role of heparanase in gastrointestinal cancer (Review). | Q36156484 | ||
| Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study | Q36328183 | ||
| Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. | Q36369402 | ||
| Invariant chain controls the activity of extracellular cathepsin L. | Q36371448 | ||
| Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis | Q36404110 | ||
| TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. | Q36944803 | ||
| Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation | Q37122091 | ||
| Heparanase: one molecule with multiple functions in cancer progression | Q37228578 | ||
| Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound | Q37365612 | ||
| Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism? | Q37407186 | ||
| Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer | Q37733245 | ||
| Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells. | Q38322333 | ||
| Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1. | Q38346025 | ||
| Collagen-binding integrin alpha1beta1 regulates intestinal inflammation in experimental colitis | Q39740150 | ||
| Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. | Q39758196 | ||
| Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence | Q40293935 | ||
| Conditional signaling by Toll-like receptor 4. | Q40452634 | ||
| Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. | Q40464583 | ||
| Heparanase expression in human colorectal cancer and its relationship to tumor angiogenesis, hematogenous metastasis, and prognosis | Q40521421 | ||
| Inflammatory cytokines and fatty acids regulate endothelial cell heparanase expression | Q40562955 | ||
| The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells | Q40726959 | ||
| Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway | Q40819427 | ||
| Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors | Q42544853 | ||
| Role of cytokines in inflammatory bowel disease | Q43065113 | ||
| Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model | Q44118739 | ||
| A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice | Q44753508 | ||
| Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. | Q44755672 | ||
| Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior | Q44760488 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | inflammation | Q101991 |
| P304 | page(s) | 1709-1721 | |
| P577 | publication date | 2011-04-01 | |
| P1433 | published in | Journal of Clinical Investigation | Q3186904 |
| P1476 | title | Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice | |
| P478 | volume | 121 |
| Q35660062 | 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway |
| Q39331826 | Astragalus embranaceus extract activates immune response in macrophages via heparanase. |
| Q37505173 | Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects |
| Q37970398 | Colorectal cancer mouse models: integrating inflammation and the stroma |
| Q36298538 | Deciphering mode of action of heparanase using structurally defined oligosaccharides |
| Q27015979 | ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation |
| Q91798106 | Forty Years of Basic and Translational Heparanase Research |
| Q41709484 | Gemcitabine-induced heparanase promotes aggressiveness of pancreatic cancer cells via activating EGFR signaling. |
| Q38366332 | Glycosylation alterations in lung and brain cancer |
| Q58585910 | Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity |
| Q47888806 | Heparan Sulfate Proteoglycans as Relays of Neuroinflammation. |
| Q38116039 | Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses |
| Q40341695 | Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis |
| Q37413886 | Heparanase and autoimmune diabetes. |
| Q43812376 | Heparanase and macrophage interplay in the onset of liver fibrosis |
| Q37746011 | Heparanase augments insulin receptor signaling in breast carcinoma |
| Q34052534 | Heparanase cooperates with Ras to drive breast and skin tumorigenesis |
| Q37983752 | Heparanase enzyme in chronic inflammatory bowel disease and colon cancer |
| Q38080632 | Heparanase in inflammation and inflammation-associated cancer |
| Q35838889 | Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer |
| Q60910621 | Heparanase inhibitors restrain mesothelioma |
| Q37500036 | Heparanase interacts with resistin and augments its activity |
| Q39782778 | Heparanase is essential for the development of diabetic nephropathy in mice. |
| Q33761544 | Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice |
| Q38985052 | Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy |
| Q90183482 | Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling |
| Q36498218 | Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis |
| Q60931211 | Heparanase: A Multitasking Protein Involved in Extracellular Matrix (ECM) Remodeling and Intracellular Events |
| Q42587945 | Heparanase: From basic research to therapeutic applications in cancer and inflammation |
| Q38801721 | Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases |
| Q39120713 | Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease |
| Q38574126 | Heparins in ulcerative colitis: proposed mechanisms of action and potential reasons for inconsistent clinical outcomes |
| Q35695593 | High glucose-induced intestinal epithelial barrier damage is aggravated by syndecan-1 destruction and heparanase overexpression |
| Q36328686 | Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity |
| Q28083753 | Impact of heparanase on renal fibrosis |
| Q37562372 | Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma |
| Q35024882 | Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms |
| Q35636604 | Involvement of Heparanase in Empyema: Implication for Novel Therapeutic Approaches |
| Q64903949 | Involvement of Heparanase in the Pathogenesis of Mesothelioma: Basic Aspects and Clinical Applications. |
| Q27025052 | Involvement of heparanase in atherosclerosis and other vessel wall pathologies |
| Q64081265 | Leukocyte Heparanase: A Double-Edged Sword in Tumor Progression |
| Q50133247 | Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans. |
| Q60909538 | MET/HGF Co-Targeting in Pancreatic Cancer: A Tool to Provide Insight into the Tumor/Stroma Crosstalk |
| Q36542354 | Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression |
| Q35102577 | Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme |
| Q28396123 | Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response |
| Q33714011 | Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP. |
| Q37297568 | Overexpression of gelsolin reduces the proliferation and invasion of colon carcinoma cells |
| Q42291940 | Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis |
| Q40490330 | PI-88 inhibits postoperative recurrence of hepatocellular carcinoma via disrupting the surge of heparanase after liver resection |
| Q41116266 | Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model |
| Q34140460 | Polymorphisms and a haplotype in heparanase gene associations with the progression and prognosis of gastric cancer in a northern Chinese population. |
| Q89285673 | Preventive effect on endothelial surface layer damage of Fusu agent in LPS-induced acute lung injury in rats |
| Q36816444 | Proteoglycans and their roles in brain cancer |
| Q92541928 | Regulation of Heparanase in Diabetes-Associated Pancreatic Carcinoma |
| Q51640772 | Serum heparanase concentration and heparanase activity in patients with retinal vein occlusion. |
| Q36101233 | Significance of heparanase in cancer and inflammation |
| Q54267579 | Syndecan-1 and heparanase: potential markers for activity evaluation and differential diagnosis of Crohn's disease. |
| Q36325314 | Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma |
| Q64096011 | Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression |
| Q92137106 | Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds |
| Q38718475 | The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression |
| Q47207922 | The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies. |
| Q42004230 | The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target |
| Q36452903 | The potential of heparanase as a therapeutic target in cancer |
| Q37045970 | The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. |
| Q35651533 | The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus |
| Q91682933 | Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells |
| Q35853992 | Unfractionated heparin attenuates intestinal injury in mouse model of sepsis by inhibiting heparanase |
| Q33770777 | Versatile role of heparanase in inflammation |
| Q40706221 | Vitamin D attenuates proteinuria by inhibition of heparanase expression in the podocyte |
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