Systematic screens for human disease genes, from yeast to human and back

scientific article published on 25 September 2007

Systematic screens for human disease genes, from yeast to human and back is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/B709494A
P698PubMed publication ID18075670

P50authorLars M SteinmetzQ55154863
Fabiana PerocchiQ21259697
P2093author name stringEugenio Mancera
P2860cites workMitochondrial encephalomyopathies: diagnostic approach.Q47652386
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's diseaseQ47754186
Loss of p53 transcriptional activity in hepatocellular carcinoma evaluated by yeast-based functional assay: comparison with p53 immunohistochemistryQ47960827
Yeast genes and human diseaseQ48066231
The relative merits of the tetO2 and tetO7 promoter systems for the functional analysis of heterologous genes in yeast and a compilation of essential yeast genes with tetO2 promoter substitutions.Q49169000
Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteinsQ56029136
A Robust Toolkit for Functional Profiling of the Yeast GenomeQ57077216
Probabilistic model of the human protein-protein interaction networkQ58482561
Sequencers step up to the speed challengeQ59008108
Towards a proteome-scale map of the human protein–protein interaction networkQ21735930
Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signalingQ22010510
Mitochondrial evolutionQ22065556
The genome sequence of Rickettsia prowazekii and the origin of mitochondriaQ22122428
Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cellsQ22253852
A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiencyQ22253915
Functional organization of the yeast proteome by systematic analysis of protein complexesQ24292209
Characterization of the human heart mitochondrial proteomeQ24294999
MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletionQ24313262
Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in YeastQ24314476
A human protein-protein interaction network: a resource for annotating the proteomeQ24324450
Hereditary early-onset Parkinson's disease caused by mutations in PINK1Q24337084
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degenerationQ24337490
A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16Q24535681
MPact: the MIPS protein interaction resource on yeastQ24538008
From genomics to chemical genomics: new developments in KEGGQ24538628
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomicsQ24541342
Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disordersQ24558589
GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1LQ24617140
Cluster analysis and display of genome-wide expression patternsQ24644463
The use of gene clusters to infer functional couplingQ24673189
STRING 7--recent developments in the integration and prediction of protein interactionsQ24675384
On the origin of mitochondria: a genomics perspectiveQ24675868
The human disease networkQ24678240
Integrative analysis of the mitochondrial proteome in yeastQ24793149
MitoP2: the mitochondrial proteome database--now including mouse dataQ25256675
Global analysis of protein localization in budding yeastQ27653962
The proteome of Saccharomyces cerevisiae mitochondriaQ27653963
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomicsQ27653964
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic ScaleQ27860705
A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiaeQ27860755
Transcriptional regulatory networks in Saccharomyces cerevisiaeQ27860846
Network biology: understanding the cell's functional organizationQ27861027
A comprehensive two-hybrid analysis to explore the yeast protein interactomeQ27861093
Proteome survey reveals modularity of the yeast cell machineryQ27929510
Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiaeQ27932416
Exploration of essential gene functions via titratable promoter allelesQ27933619
Global mapping of the yeast genetic interaction networkQ27934987
Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clustersQ27936646
Assessing systems properties of yeast mitochondria through an interaction map of the organelleQ27937134
Global landscape of protein complexes in the yeast Saccharomyces cerevisiaeQ27938796
Functional discovery via a compendium of expression profilesQ27938962
The Saccharomyces cerevisiae Pet309 protein is embedded in the mitochondrial inner membraneQ27940098
Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)Q28117190
Systematic genetic analysis with ordered arrays of yeast deletion mutantsQ28131618
Genome-wide location and function of DNA binding proteinsQ28131765
Systematic determination of genetic network architectureQ28138580
Predicting subcellular localization of proteins based on their N-terminal amino acid sequenceQ28140578
Mitochondria: dynamic organelles in disease, aging, and developmentQ28249783
Mass spectrometry-based proteomics turns quantitativeQ28291379
Proteomic analysis of the mouse liver mitochondrial inner membraneQ28587359
Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profilingQ28588350
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondriaQ28593536
Measuring genome evolutionQ28776160
Assigning protein functions by comparative genome analysis: Protein phylogenetic profilesQ29039336
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetesQ29547229
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicineQ29547303
Comparative assessment of large-scale data sets of protein-protein interactionsQ29547451
Detecting protein function and protein-protein interactions from genome sequencesQ29547473
Computational method to predict mitochondrially imported proteins and their targeting sequencesQ29547581
Mitochondria, oxidants, and agingQ29547594
Mitochondrial diseases in man and mouseQ29614555
Global analysis of protein phosphorylation in yeastQ29615057
Integrated genomic and proteomic analyses of a systematically perturbed metabolic networkQ29616021
Protein interaction maps for complete genomes based on gene fusion eventsQ29616048
Conservation of gene order: a fingerprint of proteins that physically interactQ29616049
Subcellular localization of the yeast proteomeQ29617265
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivatorsQ29617353
Mitochondria: more than just a powerhouseQ29617386
Genetic dissection of complex traitsQ29618312
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2Q29618838
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex diseaseQ29619085
Molecular Pathways of Neurodegeneration in Parkinson's DiseaseQ29619903
A Set of Vectors with a Tetracycline-Regulatable Promoter System for Modulated Gene Expression in Saccharomyces cerevisiaeQ29620316
Literature mining for the biologist: from information retrieval to biological discoveryQ30002370
Methods of assaying Bcl-2 and Bax family proteins in yeastQ30668915
Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assaysQ30767606
Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle.Q30777871
Using yeast to place human genes in functional categoriesQ30884563
Defining transcription modules using large-scale gene expression dataQ30916115
Integrating high-throughput and computational data elucidates bacterial networksQ30928624
Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical dataQ30939059
Analysis of yeast protein kinases using protein chips.Q30955396
Systematic identification of human mitochondrial disease genes through integrative genomicsQ34508388
A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogensQ34635740
Evaluation of a recombinant yeast cell estrogen screening assayQ34639220
Yeast and drug discoveryQ34794228
From genetics and genomics to drug discovery: yeast rises to the challengeQ35012193
High-throughput cell-based assays in yeastQ35053144
Global organellar proteomicsQ35062593
Functional Assays for Identifying Ligands at Orphan G Protein-Coupled ReceptorsQ35105373
Nuclear genes in mitochondrial disorders.Q35145869
Mitochondrial genomes: anything goesQ35595038
From syndrome families to functional genomicsQ35813867
Mitochondriomics or what makes us breathe.Q35913678
The epidemiology of mitochondrial disorders--past, present and futureQ35970168
Yeast as a model for medical and medicinal researchQ36110191
Mitochondrial DNA and diseaseQ36194900
Building the mitochondrial proteomeQ36227948
Proteomics of organelles and large cellular structuresQ36289104
Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiaeQ36421867
Biomarkers for amyotrophic lateral sclerosisQ36481118
Critical dependence of neurons on mitochondrial dynamicsQ36509524
Systems biology of SNPsQ36527343
Organellar proteomics: turning inventories into insightsQ36585727
Mitochondrial disease--its impact, etiology, and pathology.Q36707793
Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genesQ38518470
MiGenes: a searchable interspecies database of mitochondrial proteins curated using gene ontology annotation.Q38519301
The dual origin of the yeast mitochondrial proteomeQ39802399
Predicting protein function by genomic context: quantitative evaluation and qualitative inferencesQ40414366
Systems biology and new technologies enable predictive and preventative medicine.Q40473946
Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae.Q40849308
Functional genomics: lessons from yeastQ40869033
From gene to screen with yeastQ41536345
Genome-wide analysis of mRNAs targeted to yeast mitochondriaQ42012883
Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutantsQ43652223
Detection of TP53 mutation in ameloblastoma by the use of a yeast functional assayQ44148270
Reconstitution of gamma-secretase activityQ44393107
Isolation of drugs active against mammalian prions using a yeast-based screening assayQ44544140
Development of a rapid yeast estrogen bioassay, based on the expression of green fluorescent protein.Q44707543
MITOPRED: a genome-scale method for prediction of nucleus-encoded mitochondrial proteins.Q45988487
Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry.Q45995831
Edg-2/Vzg-1 Couples to the Yeast Pheromone Response Pathway Selectively in Response to Lysophosphatidic AcidQ46053901
Clinical evaluation of p53 mutations in urothelial carcinoma by IHC and FASAY.Q47627937
A genetic approach to identifying mitochondrial proteinsQ31130979
Ku70 suppresses the apoptotic translocation of Bax to mitochondria.Q31136038
Yeast Assays for G-Protein-Coupled ReceptorsQ31138105
G-protein-coupled receptors in Saccharomyces cerevisiae: high-throughput screening assays for drug discoveryQ32159805
Parallel analysis of mutant human glucose 6-phosphate dehydrogenase in yeast using PCR coloniesQ33224204
Metabolic profiling of patients with schizophreniaQ33255317
High-throughput profiling of the mitochondrial proteome using affinity fractionation and automationQ33925391
A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure.Q34088669
The genetics and pathology of oxidative phosphorylationQ34237999
Epidemiology and treatment of mitochondrial disordersQ34386766
Mutations of SURF-1 in Leigh disease associated with cytochrome c oxidase deficiencyQ34388122
A simple p53 functional assay for screening cell lines, blood, and tumorsQ34397902
Mitochondrial function in normal and diabetic β-cellsQ34462332
P433issue1
P304page(s)18-29
P577publication date2007-09-25
P13046publication type of scholarly workreview articleQ7318358
P1433published inMolecular BioSystemsQ3319467
P1476titleSystematic screens for human disease genes, from yeast to human and back
P478volume4

Reverse relations

cites work (P2860)
Q37682377A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus
Q28708978Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases
Q41583862Chemobiology at happy hour: yeast as a model for pharmacological screening
Q34087002Comparative and chemical proteomic approaches reveal gatifloxacin deregulates enzymes involved in glucose metabolism
Q27939191Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis
Q37396010Contemporary, yeast-based approaches to understanding human genetic variation
Q90258074Coupling of Human Rhodopsin to a Yeast Signaling Pathway Enables Characterization of Mutations Associated with Retinal Disease
Q34537161Decoupling epigenetic and genetic effects through systematic analysis of gene position
Q33419869Directing experimental biology: a case study in mitochondrial biogenesis
Q37260576Evidence that msh1p plays multiple roles in mitochondrial base excision repair
Q38511550Identification of candidate disease genes by integrating Gene Ontologies and protein-interaction networks: case study of primary immunodeficiencies.
Q37413833Identification of mitochondrial disease genes through integrative analysis of multiple datasets
Q46684221Influence of Ogg1 repair on the genetic stability of ccc2 mutant of Saccharomyces cerevisiae chemically challenged with 4-nitroquinoline-1-oxide (4-NQO).
Q93376277Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae
Q37800527Mitochondrial involvement in cell death of non-mammalian eukaryotes
Q52630605Prediction of the functional effect of novel SLC25A13 variants using a S. cerevisiae model of AGC2 deficiency
Q33597953Quantitative proteomics by metabolic labeling of model organisms
Q35880992Scope and limitations of yeast as a model organism for studying human tissue-specific pathways
Q37809824Subcellular fractionation methods and strategies for proteomics
Q34307532Untangling the Roles of Anti-Apoptosis in Regulating Programmed Cell Death using Humanized Yeast Cells
Q91995143Yeast as a Tool for Deeper Understanding of Human Manganese-Related Diseases
Q55635393Yeast-Based Screen to Identify Natural Compounds with a Potential Therapeutic Effect in Hailey-Hailey Disease.

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