Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

scientific article (publication date: 13 April 1999)

Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1999PNAS...96.4285P
P356DOI10.1073/PNAS.96.8.4285
P3181OpenCitations bibliographic resource ID343269
P932PMC publication ID16324
P698PubMed publication ID10200254
P5875ResearchGate publication ID13098474

P50authorMatteo PellegriniQ41172848
P2093author name stringD. Eisenberg
E. M. Marcotte
M. J. Thompson
T. O. Yeates
P2860cites workGapped BLAST and PSI-BLAST: a new generation of protein database search programsQ24545170
The complete genome sequence of Escherichia coli K-12Q27860542
Predicting function: from genes to genomes and backQ28286883
Constructing multigenome views of whole microbial genomes.Q31998200
Bioinformatics: from genome data to biological knowledge.Q32151706
The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998.Q32178008
Genes and proteins of Escherichia coli K-12.Q34646187
EcoCyc: Encyclopedia of Escherichia coli genes and metabolismQ34651228
Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coliQ36819467
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectphylogeneticsQ171184
P304page(s)4285-4288
P577publication date1999-04-13
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAssigning protein functions by comparative genome analysis: protein phylogenetic profiles
P478volume96

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Q33321071High-precision high-coverage functional inference from integrated data sources
Q33289001High-throughput identification of interacting protein-protein binding sites
Q34136223High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency
Q34063510Highways of gene sharing in prokaryotes
Q42212125Homology modelling of protein-protein complexes: a simple method and its possibilities and limitations.
Q41847575Horizontally transferred genes cluster spatially and metabolically
Q24790990How biologically relevant are interaction-based modules in protein networks?
Q21134980How did the spider cross the river? Behavioral adaptations for river-bridging webs in Caerostris darwini (Araneae: Araneidae)
Q36766852How to comprehensively analyse proteins and how this influences nutritional research
Q43460248Human protein-protein interaction prediction by a novel sequence-based co-evolution method: co-evolutionary divergence
Q33368056Identification and analysis of co-occurrence networks with NetCutter.
Q30002330Identification and analysis of evolutionarily cohesive functional modules in protein networks
Q112312969Identification and characterization of genes related to salt stress tolerance within segregation distortion regions of genetic map in F2 population of upland cotton
Q34326112Identification and functional analysis of 'hypothetical' genes expressed in Haemophilus influenzae
Q33359587Identification and functional characterization of gene components of Type VI Secretion system in bacterial genomes
Q91806556Identification of Moonlighting Proteins in Genomes Using Text Mining Techniques
Q34645119Identification of a fourth family of lycopene cyclases in photosynthetic bacteria
Q46843737Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling
Q24630006Identification of genes encoding tRNA modification enzymes by comparative genomics
Q35192752Identification of host-microbe interaction factors in the genomes of soft rot-associated pathogens Dickeya dadantii 3937 and Pectobacterium carotovorum WPP14 with supervised machine learning.
Q39175163Identification of hub proteins from sequence
Q35037874Identification of potential interaction networks using sequence-based searches for conserved protein-protein interactions or "interologs".
Q34525141Identification of putative rhamnogalacturonan-II specific glycosyltransferases in Arabidopsis using a combination of bioinformatics approaches
Q42584215Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence
Q28473568Identifying cognate binding pairs among a large set of paralogs: the case of PE/PPE proteins of Mycobacterium tuberculosis
Q44518986Identifying functional links between genes by evolutionary transcriptomics.
Q77876822Identifying functional links between genes using conserved chromosomal proximity
Q33237950Identifying metabolic enzymes with multiple types of association evidence
Q33582802Identifying overrepresented concepts in gene lists from literature: a statistical approach based on Poisson mixture model
Q54690940Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death.
Q24796982Implications for domain fusion protein-protein interactions based on structural information
Q36089866Improvement in Protein Domain Identification Is Reached by Breaking Consensus, with the Agreement of Many Profiles and Domain Co-occurrence
Q33673805Improvement of domain-level ortholog clustering by optimizing domain-specific sum-of-pairs score
Q50420865Improving prediction of heterodimeric protein complexes using combination with pairwise kernel.
Q33328326Improving protein function prediction methods with integrated literature data
Q47266675Improving protein protein interaction prediction based on phylogenetic information using a least-squares support vector machine
Q24811498Improving the precision of the structure-function relationship by considering phylogenetic context
Q42064841Improving the prediction of yeast protein function using weighted protein-protein interactions
Q33281129In silico pathway reconstruction: Iron-sulfur cluster biogenesis in Saccharomyces cerevisiae.
Q45967003In silico prediction of the peroxisomal proteome in fungi, plants and animals.
Q33418943In silico prioritisation of candidate genes for prokaryotic gene function discovery: an application of phylogenetic profiles.
Q54547905In silico two-hybrid system for the selection of physically interacting protein pairs.
Q42687787In vivo interaction between the polyprenol phosphate mannose synthase Ppm1 and the integral membrane protein Ppm2 from Mycobacterium smegmatis revealed by a bacterial two-hybrid system
Q33304043InPrePPI: an integrated evaluation method based on genomic context for predicting protein-protein interactions in prokaryotic genomes
Q33550772Inference of functional relations in predicted protein networks with a machine learning approach
Q24797198Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach
Q39023260Inferring Trees
Q35806010Inferring domain-domain interactions from protein-protein interactions
Q46880217Inferring functional information from domain co-evolution
Q33893320Inferring functional modules of protein families with probabilistic topic models.
Q40619848Inferring gene function from evolutionary change in signatures of translation efficiency
Q31104442Inferring genome-wide functional linkages in E. coli by combining improved genome context methods: comparison with high-throughput experimental data
Q34569064Inferring homologous protein-protein interactions through pair position specific scoring matrix
Q21045419Inferring horizontal gene transfer
Q30482747Inferring modules of functionally interacting proteins using the Bond Energy Algorithm.
Q24796950Information assessment on predicting protein-protein interactions
Q37748492Innovative bioinformatic approaches for developing peptide-based vaccines against hypervariable viruses
Q42509091Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling
Q34883678Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection
Q33247445Integrated assessment and prediction of transcription factor binding
Q21284254Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networks
Q33609193Integrating physical and genetic maps: from genomes to interaction networks
Q30628119Integration of genome data and protein structures: prediction of protein folds, protein interactions and "molecular phenotypes" of single nucleotide polymorphisms
Q37169808Integration of phenotypic metadata and protein similarity in Archaea using a spectral bipartitioning approach
Q24306825Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
Q34514384Inter-Protein Sequence Co-Evolution Predicts Known Physical Interactions in Bacterial Ribosomes and the Trp Operon
Q47442338Inter-residue, inter-protein and inter-family coevolution: bridging the scales.
Q30399514InterPred: A pipeline to identify and model protein-protein interactions.
Q39535240Interaction generality, a measurement to assess the reliability of a protein-protein interaction
Q29615776Interaction network containing conserved and essential protein complexes in Escherichia coli
Q54311731Interaction network in cyanobacterial nitrogen regulation: PipX, a protein that interacts in a 2-oxoglutarate dependent manner with PII and NtcA.
Q31162634Interactome data and databases: different types of protein interaction
Q38010411Interactome mapping for analysis of complex phenotypes: insights from benchmarking binary interaction assays
Q36257382Interactome: gateway into systems biology
Q33294540Interplay between network structures, regulatory modes and sensing mechanisms of transcription factors in the transcriptional regulatory network of E. coli
Q34027140Interrogating protein interaction networks through structural biology
Q92267126Interspecies association mapping links reduced CG to TG substitution rates to the loss of gene-body methylation
Q89489979Into the wild: new yeast genomes from natural environments and new tools for their analysis
Q40918605Investigating Moorella thermoacetica metabolism with a genome-scale constraint-based metabolic model.
Q87370078Investigating co-evolution of functionally associated phosphosites in human
Q33304236Investigation of factors affecting prediction of protein-protein interaction networks by phylogenetic profiling
Q36531717Investigation of glycan evolution based on a comprehensive analysis of glycosyltransferases using phylogenetic profiling.
Q41018971Itinerary profiling to analyze a large number of protein-folding trajectories
Q42690307Joint learning of gene functions--a Bayesian network model approach
Q38460563KEGG OC: a large-scale automatic construction of taxonomy-based ortholog clusters
Q24817122Kernel-based machine learning protocol for predicting DNA-binding proteins
Q30364926Large Scale Chemical Cross-linking Mass Spectrometry Perspectives.
Q57007326Large-Scale Comparative Genomic Analyses of Cytoplasmic Membrane Transport Systems in Prokaryotes
Q34294587Large-scale analysis of microRNA evolution
Q37827559Lateral genetic transfer and the construction of genetic exchange communities
Q21145276Life in hot carbon monoxide: the complete genome sequence of Carboxydothermus hydrogenoformans Z-2901
Q24675220Lineage-specific loss and divergence of functionally linked genes in eukaryotes
Q33921865Localizing proteins in the cell from their phylogenetic profiles.
Q46080127Locally defined protein phylogenetic profiles reveal previously missed protein interactions and functional relationships
Q33992757Long-chain N-acyl amino acid synthases are linked to the putative PEP-CTERM/exosortase protein-sorting system in Gram-negative bacteria
Q37746962Loss and gain of GroEL in the Mollicutes.
Q38295261LysM domains from Pteris ryukyuensis chitinase-A: a stability study and characterization of the chitin-binding site
Q33600892MBGD update 2010: toward a comprehensive resource for exploring microbial genome diversity
Q35159357MBGD: microbial genome database for comparative analysis
Q40586801MIRAGE: a functional genomics-based approach for metabolic network model reconstruction and its application to cyanobacteria networks
Q47304411MOCASSIN-prot: A Multi-Objective Clustering Approach for Protein Similarity Networks
Q25257010MaGe: a microbial genome annotation system supported by synteny results
Q33780899Making connections between novel transcription factors and their DNA motifs.
Q36742805Making the connections--the crucial role of metabolite transporters at the interface between chloroplast and cytosol.
Q43920334Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods
Q64387955Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes
Q28752683Massive comparative genomic analysis reveals convergent evolution of specialized bacteria
Q42082146Meta-analysis of general bacterial subclades in whole-genome phylogenies using tree topology profiling
Q45943697Metabolic Pathway Assignment of Plant Genes based on Phylogenetic Profiling-A Feasibility Study.
Q30279122Metabolic network modeling of microbial communities
Q41949939Metabolic pathway reconstruction of eugenol to vanillin bioconversion in Aspergillus niger.
Q28074539Metabolic pathway reconstruction strategies for central metabolism and natural product biosynthesis
Q34937774Metagenomic guilt by association: an operonic perspective
Q30578902MicroScope--an integrated microbial resource for the curation and comparative analysis of genomic and metabolic data
Q33531416MicroScope: a platform for microbial genome annotation and comparative genomics
Q33333213Microbial genotype-phenotype mapping by class association rule mining
Q34094923Mining bacterial genomes for antimicrobial targets
Q38149723Minireview: applied structural bioinformatics in proteomics
Q33705060Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation
Q30030541Model-enabled gene search (MEGS) allows fast and direct discovery of enzymatic and transport gene functions in the marine bacterium Vibrio fischeri.
Q33371821Modifying the DPClus algorithm for identifying protein complexes based on new topological structures
Q74431979Modularity in the gain and loss of genes: applications for function prediction
Q51735031Modules of co-occurrence in the cyanobacterial pan-genome reveal functional associations between groups of ortholog genes.
Q47792928Molecular evolution of lysin motif-type receptor-like kinases in plants
Q29568187Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis
Q30764897Motif-based fold assignment
Q36434721MouseNet v2: a database of gene networks for studying the laboratory mouse and eight other model vertebrates.
Q33490835Multi-level learning: improving the prediction of protein, domain and residue interactions by allowing information flow between levels
Q33499113MultiLoc2: integrating phylogeny and Gene Ontology terms improves subcellular protein localization prediction
Q40829773Multimeric threading-based prediction of protein-protein interactions on a genomic scale: application to the Saccharomyces cerevisiae proteome
Q34280166Multiple alignment of complete sequences (MACS) in the post-genomic era.
Q41338172Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway
Q30370660Multiple sequence alignments as tools for protein structure and function prediction.
Q35965216Mycobacterium tuberculosis and Clostridium difficille interactomes: demonstration of rapid development of computational system for bacterial interactome prediction
Q24620084NAPP: the Nucleic Acid Phylogenetic Profile Database
Q24796432Nebulon: a system for the inference of functional relationships of gene products from the rearrangement of predicted operons
Q38447168Network analysis and cross species comparison of protein-protein interaction networks of human, mouse and rat cytochrome P450 proteins that degrade xenobiotics.
Q21560992Network compression as a quality measure for protein interaction networks
Q35015314Network genomics--a novel approach for the analysis of biological systems in the post-genomic era.
Q38815372Network-Based Gene Function Prediction in Mouse and Other Model Vertebrates Using MouseNet Server
Q37775135Network-based function prediction and interactomics: the case for metabolic enzymes
Q61811426Network-based microsynteny analysis identifies major differences and genomic outliers in mammalian and angiosperm genomes
Q38914293Networks of ProteinProtein Interactions: From Uncertainty to Molecular Details.
Q62689583New Long-Term Memory Genes Revealed by Assessing Computational Function Prediction Methods
Q45801913New genetic associations in thiopurine-related bone marrow toxicity among inflammatory bowel disease patients.
Q30705590Nitrogen assimilation in Escherichia coli: putting molecular data into a systems perspective
Q30559749Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish
Q34613793Novel genes exhibit distinct patterns of function acquisition and network integration
Q92675086Novel phylogenetic methods are needed for understanding gene function in the era of mega-scale genome sequencing
Q92999345OMA standalone: orthology inference among public and custom genomes and transcriptomes
Q33302712On the detection of functionally coherent groups of protein domains with an extension to protein annotation
Q41847454Open source tool for prediction of genome wide protein-protein interaction network based on ortholog information
Q42940094Operon prediction for sequenced bacterial genomes without experimental information
Q35646651Operon prediction using both genome-specific and general genomic information
Q36511729Orphan SelD proteins and selenium-dependent molybdenum hydroxylases
Q34039734Ortho2ExpressMatrix--a web server that interprets cross-species gene expression data by gene family information
Q58090462OrthoInspector 3.0: open portal for comparative genomics
Q50602540Orthogenomics of photosynthetic organisms: bioinformatic and experimental analysis of chloroplast proteins of endosymbiont origin in Arabidopsis and their counterparts in Synechocystis.
Q38815377Ortholog Identification and Comparative Analysis of Microbial Genomes Using MBGD and RECOG.
Q36361689Orthoscape: a cytoscape application for grouping and visualization KEGG based gene networks by taxonomy and homology principles.
Q30859106Overview of software options for processing, analysis and interpretation of mass spectrometric proteomic data
Q48118907Oxidative stress gene expression profile in inbred mouse after ischemia/reperfusion small bowel injury
Q24791114PCOGR: phylogenetic COG ranking as an online tool to judge the specificity of COGs with respect to freely definable groups of organisms
Q36204412PPCM: Combing Multiple Classifiers to Improve Protein-Protein Interaction Prediction
Q37245673PPISearch: a web server for searching homologous protein-protein interactions across multiple species.
Q33901481PRIN: a predicted rice interactome network
Q24796893PartiGeneDB--collating partial genomes
Q36479565PatchSurfers: Two methods for local molecular property-based binding ligand prediction
Q42619738Pathogen profiling for disease management and surveillance.
Q30375382Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods.
Q33313510Persistence drives gene clustering in bacterial genomes
Q35194747Pharmacophylogenomics: genes, evolution and drug targets
Q35127370Pharmacoproteomics in drug development
Q24815778Phydbac "Gene Function Predictor": a gene annotation tool based on genomic context analysis
Q39804537Phydbac (phylogenomic display of bacterial genes): An interactive resource for the annotation of bacterial genomes
Q41010528Phydbac2: improved inference of gene function using interactive phylogenomic profiling and chromosomal location analysis
Q34544393Phyletic profiling with cliques of orthologs is enhanced by signatures of paralogy relationships
Q35630176PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification
Q39015302PhyloPro2.0: a database for the dynamic exploration of phylogenetically conserved proteins and their domain architectures across the Eukarya
Q41613516Phylo_dCor: distance correlation as a novel metric for phylogenetic profiling
Q58733687Phylogenetic Clustering of Genes Reveals Shared Evolutionary Trajectories and Putative Gene Functions
Q30157037Phylogenetic Profiles Reveal Structural and Functional Determinants of Lipid-binding
Q28074488Phylogenetic Profiling for Probing the Modular Architecture of the Human Genome
Q47280089Phylogenetic Profiling of Mitochondrial Proteins and Integration Analysis of Bacterial Transcription Units Suggest Evolution of F1Fo ATP Synthase from Multiple Modules
Q33411072Phylogenetic diversity of stress signalling pathways in fungi
Q37079528Phylogenetic portrait of the Saccharomyces cerevisiae functional genome
Q36858814Phylogenetic profiles reveal evolutionary relationships within the "twilight zone" of sequence similarity
Q24797489Phylogenetic profiling of the Arabidopsis thaliana proteome: what proteins distinguish plants from other organisms?
Q30892241Phylogenetic profiling: how much input data is enough?
Q33268698Phylogenetic tree information aids supervised learning for predicting protein-protein interaction based on distance matrices
Q34102051Phylogenetically informed logic relationships improve detection of biological network organization
Q47209968Phylogenomic Synteny Network Analysis of MADS-Box Transcription Factor Genes Reveals Lineage-Specific Transpositions, Ancient Tandem Duplications, and Deep Positional Conservation
Q21563646Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements
Q30394741Phylogeny vs genome reshuffling: horizontal gene transfer
Q33516895Phylogeny-guided interaction mapping in seven eukaryotes
Q34842519Physical protein-protein interactions predicted from microarrays
Q30388661PoGO: Prediction of Gene Ontology terms for fungal proteins.
Q37169034PoplarGene: poplar gene network and resource for mining functional information for genes from woody plants
Q35658253Positional clustering improves computational binding site detection and identifies novel cis-regulatory sites in mammalian GABAA receptor subunit genes
Q33186645Potential genomic determinants of hyperthermophily
Q36834546Practical and theoretical advances in predicting the function of a protein by its phylogenetic distribution
Q37024705Practical applications of bacterial functional genomics.
Q34391358Practical aspects of protein co-evolution
Q24806232Practical lessons from protein structure prediction
Q41575762PrePhyloPro: phylogenetic profile-based prediction of whole proteome linkages
Q41274007Predicted networks of protein-protein interactions in Stegodyphus mimosarum by cross-species comparisons
Q38654083Predicting Functional Interactions Among Genes in Prokaryotes by Genomic Context.
Q30002397Predicting biological networks from genomic data
Q24811440Predicting functional gene links from phylogenetic-statistical analyses of whole genomes
Q35050912Predicting gene function using similarity learning
Q43227038Predicting genes for orphan metabolic activities using phylogenetic profiles
Q34018348Predicting genetic modifier loci using functional gene networks
Q51952704Predicting interactions in protein networks by completing defective cliques.
Q33702746Predicting phenotypic traits of prokaryotes from protein domain frequencies
Q40414366Predicting protein function by genomic context: quantitative evaluation and qualitative inferences
Q37014089Predicting protein function from sequence and structure
Q33308257Predicting protein function with hierarchical phylogenetic profiles: the Gene3D Phylo-Tuner method applied to eukaryotic genomes
Q38386937Predicting protein interface residues using easily accessible on-line resources.
Q33371800Predicting protein linkages in bacteria: which method is best depends on task
Q34204567Predicting protein-ATP binding sites from primary sequence through fusing bi-profile sampling of multi-view features
Q33217293Predicting protein-protein interaction by searching evolutionary tree automorphism space
Q37660067Predicting protein-protein interactions in the context of protein evolution
Q33548907Predicting protein-protein interactions in unbalanced data using the primary structure of proteins
Q39601005Predicting regulons and their cis-regulatory motifs by comparative genomics
Q33528207Predicting the protein-protein interactions using primary structures with predicted protein surface
Q35837549Prediction and characterization of protein-protein interaction networks in swine
Q28974902Prediction and identification of sequences coding for orphan enzymes using genomic and metagenomic neighbours
Q34580039Prediction and redesign of protein-protein interactions
Q30002391Prediction of Human Protein Function from Post-translational Modifications and Localization Features
Q39541532Prediction of Protein-Protein Interaction via co-occurring Aligned Pattern Clusters
Q28078131Prediction of Protein-Protein Interactions by Evidence Combining Methods
Q40273038Prediction of Protein-Protein Interactions with Physicochemical Descriptors and Wavelet Transform via Random Forests
Q45943145Prediction of Protein-Protein Interactions.
Q34366898Prediction of RNA-binding proteins from primary sequence by a support vector machine approach
Q48150110Prediction of enzymatic pathways by integrative pathway mapping.
Q33374636Prediction of evolutionarily conserved interologs in Mus musculus.
Q24527323Prediction of functional modules based on comparative genome analysis and Gene Ontology application
Q35607697Prediction of host - pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs
Q41184191Prediction of interacting proteins from homology-modeled complex structures using sequence and structure scores.
Q28492567Prediction of missing enzyme genes in a bacterial metabolic network. Reconstruction of the lysine-degradation pathway of Pseudomonas aeruginosa
Q30002328Prediction of novel archaeal enzymes from sequence-derived features
Q47637567Prediction of protein-protein interaction networks.
Q38520195Prediction of protein-protein interactions using distant conservation of sequence patterns and structure relationships
Q47919853Prediction of protein-protein interactions using protein signature profiling
Q33241224Prediction of yeast protein-protein interaction network: insights from the Gene Ontology and annotations
Q78482210Prediction, assessment and validation of protein interaction maps in bacteria
Q34010645Predictome: a database of putative functional links between proteins
Q34070720ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process
Q33290139Probabilistic prediction and ranking of human protein-protein interactions
Q31107612Probabilistic protein function prediction from heterogeneous genome-wide data
Q24801555Prolinks: a database of protein functional linkages derived from coevolution
Q22065755Properties of overlapping genes are conserved across microbial genomes
Q40958767ProtPhylo: identification of protein-phenotype and protein-protein functional associations via phylogenetic profiling.
Q33771019Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions
Q57747933Protein Interaction Networks and Their Statistical Analysis
Q35223658Protein annotation from protein interaction networks and Gene Ontology
Q36914675Protein co-evolution, co-adaptation and interactions
Q33911778Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins
Q38681085Protein complex analysis: From raw protein lists to protein interaction networks
Q33693902Protein complex prediction based on k-connected subgraphs in protein interaction network.
Q42092310Protein content of minimal and ancestral ribosome
Q33318470Protein function assignment through mining cross-species protein-protein interactions
Q33906809Protein function in the post-genomic era.
Q38460064Protein function prediction using guilty by association from interaction networks.
Q29616048Protein interaction maps for complete genomes based on gene fusion events
Q34286374Protein interaction maps for model organisms
Q36168366Protein interaction networks
Q73256714Protein networks-built by association
Q34669644Protein-interaction networks: from experiments to analysis
Q41961515Protein-protein interaction based on pairwise similarity.
Q38272993Protein-protein interaction networks (PPI) and complex diseases.
Q34450771Protein-protein interaction predictions using text mining methods
Q62492646Protein-protein interaction sites prediction by ensemble random forests with synthetic minority oversampling technique
Q28469024Protein-protein interactions more conserved within species than across species
Q30002405Protein-protein interactions: analysis and prediction
Q34325454ProteinHistorian: tools for the comparative analysis of eukaryote protein origin
Q38254995Proteogenomics in microbiology: taking the right turn at the junction of genomics and proteomics
Q34315933Proteome-wide prediction of protein-protein interactions from high-throughput data
Q34642328Proteomic tools for biomedicine
Q34575441Proteomics: posttranslational modifications, immune responses and current analytical tools
Q36482021Quantification of ortholog losses in insects and vertebrates.
Q40622623Quantifying modularity in the evolution of biomolecular systems
Q30002368Quantitative assessment of protein function prediction from metagenomics shotgun sequences
Q28473198Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme function
Q33801141Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana
Q34448299Recent advances in computational genomics
Q34020017Recent developments and future directions in computational genomics
Q33251431Reciprocal illumination in the gene content tree of life
Q60921530Recombination of ecologically and evolutionarily significant loci maintains genetic cohesion in the Pseudomonas syringae species complex
Q33284271Reconstruction of human protein interolog network using evolutionary conserved network
Q33641446Reconstruction of the core and extended regulons of global transcription factors
Q52047756Recurrence quantification analysis reveals interaction partners in paramyxoviridae envelope glycoproteins.
Q34664857Redefining bacterial populations: a post-genomic reformation
Q33450610Relationship between phylogenetic distribution and genomic features in Neurospora crassa
Q24791625Relative predicted protein levels of functionally associated proteins are conserved across organisms
Q34081467Representing and analysing molecular and cellular function using the computer
Q36854674Resolving the network of cell signaling pathways using the evolving yeast two-hybrid system
Q36251286Revisiting operons: an analysis of the landscape of transcriptional units in E. coli
Q28611186Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis
Q33619990Role for protein-protein interaction databases in human genetics
Q42012920Role-similarity based functional prediction in networked systems: application to the yeast proteome
Q34538669Roundup: a multi-genome repository of orthologs and evolutionary distances
Q25255876SIMAP: the similarity matrix of proteins
Q34146561SPPS: a sequence-based method for predicting probability of protein-protein interaction partners
Q24675384STRING 7--recent developments in the integration and prediction of protein interactions
Q24681946STRING: a database of predicted functional associations between proteins
Q24523893STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene
Q30002354SVD-phy: improved prediction of protein functional associations through singular value decomposition of phylogenetic profiles
Q30621056Saccharomyces Genome Database provides tools to survey gene expression and functional analysis data
Q64251780Selecting Near-Native Protein Structures from Predicted Decoy Sets Using Ordered Graphlet Degree Similarity
Q34017079Selection of organisms for the co-evolution-based study of protein interactions
Q33334075Sequence similarity network reveals common ancestry of multidomain proteins
Q39625557Sequence-based prediction of protein-protein interactions by means of codon usage.
Q34845004Shared protein complex subunits contribute to explaining disrupted co-occurrence
Q55035526Similarity of phylogenetic trees as indicator of protein-protein interaction.
Q30477519Similarity searches in genome-wide numerical data sets
Q34328058Simulated evolution of protein-protein interaction networks with realistic topology
Q30394016Simultaneous identification of specifically interacting paralogs and interprotein contacts by direct coupling analysis.
Q24648002Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles
Q33526650Sites Inferred by Metabolic Background Assertion Labeling (SIMBAL): adapting the Partial Phylogenetic Profiling algorithm to scan sequences for signatures that predict protein function
Q33463453SpaK/SpaR two-component system characterized by a structure-driven domain-fusion method and in vitro phosphorylation studies
Q33513755Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens
Q24683633Stepwise formation of the bacterial flagellar system
Q37037777Strategies for reliable exploitation of evolutionary concepts in high throughput biology.
Q33513017Stratification of co-evolving genomic groups using ranked phylogenetic profiles
Q30489524Streamlining and large ancestral genomes in Archaea inferred with a phylogenetic birth-and-death model
Q30363264Structural bioinformatics of the interactome.
Q47588542Structural characterization of FlgE2 protein from Helicobacter pylori hook
Q52938509Structural genomics analysis: characteristics of atypical, common, and horizontally transferred folds.
Q46253521Sugar Lego: gene composition of bacterial carbohydrate metabolism genomic loci
Q35100906Supervised learning and prediction of physical interactions between human and HIV proteins
Q37571299Supra-operonic clusters of functionally related genes (SOCs) are a source of horizontal gene co-transfers
Q33393419SynteBase/SynteView: a tool to visualize gene order conservation in prokaryotic genomes
Q41046461Systematic Discovery of Human Gene Function and Principles of Modular Organization through Phylogenetic Profiling
Q24806114Systematic association of genes to phenotypes by genome and literature mining
Q36098282Systematic condition-dependent annotation of metabolic genes
Q44470521Systematic discovery of analogous enzymes in thiamin biosynthesis
Q36061303Systematic identification and analysis of frequent gene fusion events in metabolic pathways
Q64124619Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis
Q37030590Systematic screens for human disease genes, from yeast to human and back
Q35058632Systematizing the generation of missing metabolic knowledge
Q36372378Systems analysis of host-parasite interactions
Q37860613Systems biology of tuberculosis
Q30276470Systems level analysis of the Chlamydomonas reinhardtii metabolic network reveals variability in evolutionary co-conservation
Q34342155Systems level insights into the stress response to UV radiation in the halophilic archaeon Halobacterium NRC-1
Q38678916Systems-wide Studies Uncover Commander, a Multiprotein Complex Essential to Human Development.
Q34314590TIGRFAMs and Genome Properties in 2013.
Q24683561TIGRFAMs and Genome Properties: tools for the assignment of molecular function and biological process in prokaryotic genomes
Q38559450Template-based identification of protein-protein interfaces using eFindSitePPI.
Q37037798Testing the accuracy of eukaryotic phylogenetic profiles for prediction of biological function
Q36994374The Biosynthetic pathway for synechoxanthin, an aromatic carotenoid synthesized by the euryhaline, unicellular cyanobacterium Synechococcus sp. strain PCC 7002
Q21184023The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics
Q28484023The CanOE strategy: integrating genomic and metabolic contexts across multiple prokaryote genomes to find candidate genes for orphan enzymes
Q92134796The Comparison Between the Mutated HuIFN-β 27-101 and the Wild Type Interferon β: the Comprehensive In Silico Study to Evaluate the Effect of Mutations on IFN-β
Q37738644The Effects of Increasing the Number of Taxa on Inferences of Molecular Convergence
Q44876881The MORPH algorithm: ranking candidate genes for membership in Arabidopsis and tomato pathways.
Q35427460The Mitochondrial Proteome and Human Disease
Q35157897The PEDANT genome database
Q24793731The SYSTERS Protein Family Database in 2005
Q33468705The Symbiosis Interactome: a computational approach reveals novel components, functional interactions and modules in Sinorhizobium meliloti
Q35846941The TB Structural Genomics Consortium: a decade of progress
Q28775893The balance of driving forces during genome evolution in prokaryotes
Q37508088The chlamydiales pangenome revisited: structural stability and functional coherence
Q22066260The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium
Q42641021The conservation and evolutionary modularity of metabolism
Q42103322The crucial role of PNPase in the degradation of small RNAs that are not associated with Hfq.
Q27701107The crystal structure of Helicobacter pylori HP1029 highlights the functional diversity of the sialic acid-related DUF386 family
Q28487146The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis
Q42047417The distinctive signatures of promoter regions and operon junctions across prokaryotes
Q21202786The diversity and evolution of cell cycle regulation in alpha-proteobacteria: a comparative genomic analysis
Q42286183The evolutionary dynamics of functional modules and the extraordinary plasticity of regulons: the Escherichia coli perspective
Q57127814The evolutionary signal in metagenome phyletic profiles predicts many gene functions
Q44981604The genes and enzymes for the catabolism of galactitol, D-tagatose, and related carbohydrates in Klebsiella oxytoca M5a1 and other enteric bacteria display convergent evolution
Q49912618The genes of the sulphoquinovose catabolism in Escherichia coli are also associated with a previously unknown pathway of lactose degradation.
Q24814780The genomics of disulfide bonding and protein stabilization in thermophiles
Q28755465The global landscape of sequence diversity
Q37395221The human protein coevolution network.
Q40562890The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme
Q34027115The identification of functional modules from the genomic association of genes
Q34997450The language of genes
Q24551006The nitrilase superfamily: classification, structure and function
Q24681035The origins and early evolution of DNA mismatch repair genes--multiple horizontal gene transfers and co-evolution
Q24673696The origins and evolution of functional modules: lessons from protein complexes
Q34503048The origins of the evolutionary signal used to predict protein-protein interactions
Q34977461The outcomes of pathway database computations depend on pathway ontology
Q24303932The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase
Q40949739The phylogenetic extent of metabolic enzymes and pathways
Q80485545The plant-specific database. Classification of Arabidopsis proteins based on their phylogenetic profile
Q34733596The post-genomic era of interactive proteomics: facts and perspectives
Q26801105The power of operon rearrangements for predicting functional associations
Q33268914The relationship between protein sequences and their gene ontology functions
Q35051909The role of indirect connections in gene networks in predicting function
Q24793719The society of genes: networks of functional links between genes from comparative genomics
Q33347894The topology of the bacterial co-conserved protein network and its implications for predicting protein function
Q33369980The use of Gene Ontology terms for predicting highly-connected 'hub' nodes in protein-protein interaction networks
Q49222848Time-consistent reconciliation maps and forbidden time travel.
Q34980439Topological structure analysis of the protein-protein interaction network in budding yeast
Q34023960Toward an efficient method of identifying core genes for evolutionary and functional microbial phylogenies
Q27860789Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
Q38446542Towards Consensus Gene Ages
Q36689026Towards a universal group B Streptococcus vaccine using multistrain genome analysis
Q36371202Towards multidimensional genome annotation
Q36282643Towards quantitative biology: integration of biological information to elucidate disease pathways and to guide drug discovery
Q34715175Towards the prediction of protein interaction partners using physical docking
Q33307860Towards validating the hypothesis of phylogenetic profiling
Q34794275Tracing evolutionary footprints to identify novel gene functional linkages
Q52023850Trait-to-gene: a computational method for predicting the function of uncharacterized genes.
Q33696515Trees on networks: resolving statistical patterns of phylogenetic similarities among interacting proteins
Q37213785Uncovering metabolic pathways relevant to phenotypic traits of microbial genomes
Q41878629Uncovering the co-evolutionary network among prokaryotic genes
Q28731026Understanding communication signals during mycobacterial latency through predicted genome-wide protein interactions and boolean modeling
Q36168349Understanding the yeast proteome: a bioinformatics perspective
Q34334118Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis.
Q92837710Up-regulated FSTL5 inhibits invasion of hepatocellular carcinoma through the Wnt/β-catenin/YAP pathway
Q33381173Update of KDBI: Kinetic Data of Bio-molecular Interaction database.
Q43633753Using bioinformatics in gene and drug discovery
Q92237101Using discriminative vector machine model with 2DPCA to predict interactions among proteins
Q30479593Using indirect protein interactions for the prediction of Gene Ontology functions
Q30479591Using structural motif descriptors for sequence-based binding site prediction
Q36676452Using support vector machine combined with auto covariance to predict protein-protein interactions from protein sequences
Q37328570Utility of computational methods to identify the apoptosis machinery in unicellular eukaryotes
Q62111548Utilization of selenocysteine in early-branching fungal phyla
Q31010780Utilizing logical relationships in genomic data to decipher cellular processes
Q24800519VisANT: an online visualization and analysis tool for biological interaction data
Q24796237Visualisation and graph-theoretic analysis of a large-scale protein structural interactome
Q34054057Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps
Q28708807What we can learn about Escherichia coli through application of Gene Ontology
Q24804052Whither genomics?
Q30874386Who's your neighbor? New computational approaches for functional genomics
Q36852724Whole-genome annotation by using evidence integration in functional-linkage networks
Q37037782Why should we care about molecular coevolution?
Q39080836Xenolog classification
Q34139029YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors

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