Depletion of regulatory T cells decreases cardiac parasitosis and inflammation in experimental Chagas disease

scientific article published on 11 January 2015

Depletion of regulatory T cells decreases cardiac parasitosis and inflammation in experimental Chagas disease is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1043941435
P356DOI10.1007/S00436-014-4300-3
P932PMC publication ID4336812
P698PubMed publication ID25576191
P5875ResearchGate publication ID270649867

P50authorEdward ThorpQ41305505
P2093author name stringDavid M Engman
Joann M Taylor
Kevin M Bonney
Conrad L Epting
P2860cites workControl of regulatory T cell development by the transcription factor Foxp3Q27860489
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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 productionQ29619536
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IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditisQ33532584
CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in miceQ33745170
Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunityQ33809208
Regulatory T cells phenotype in different clinical forms of Chagas' diseaseQ33927456
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Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in miceQ34130172
Parasite polyclonal activators: new targets for vaccination approaches?Q34240147
Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease.Q34251395
IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophilsQ34266045
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunityQ34529549
Autoimmunity in Chagas' disease: specific inhibition of reactivity of CD4+ T cells against myosin in mice chronically infected with Trypanosoma cruzi.Q35101438
Control of T cell activation by CD4+CD25+ suppressor T cellsQ35580394
IL-4 from Th2-type cells suppresses induction of delayed-type hypersensitivity elicited shortly after immunizationQ35592442
Parasitic diseases of the heartQ35650927
Endogenous CD4(+) CD25(+) regulatory T cells have a limited role in the control of Trypanosoma cruzi infection in miceQ35689168
Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral toleranceQ35703487
Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitismQ35746981
Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' diseaseQ35779913
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Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of α-galactosyl residues.Q36080155
"Autoimmune rejection" of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissueQ36107611
The immunology of experimental Chagas' disease. 3. Rejection of allogeneic heart cells in vitroQ36273596
Regulatory T cells in immune surveillance and treatment of cancer.Q36352546
Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected miceQ36449594
CD4+ CD25+ FOXP3+ Treg cells induced by rSSP4 derived from T. cruzi amastigotes increase parasitemia in an experimental Chagas disease modelQ36665012
Role of Th1 and Th17 cells in organ-specific autoimmunity.Q37172965
Chagas heart disease pathogenesis: one mechanism or many?Q37264799
Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease).Q37467729
Innate immunity and regulatory T-cells in human Chagas disease: what must be understood?Q37597066
Human FoxP3+ regulatory T cells in systemic autoimmune diseasesQ37881234
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR.Q38957765
Trypanosoma Cruzi-Sensitized T-Lymphocyte Mediated 51Cr Release from Human Heart Cells in Chagas' Disease *Q39522787
Evidence that development of severe cardiomyopathy in human Chagas' disease is due to a Th1-specific immune responseQ39730057
Administration of a nondepleting anti-CD25 monoclonal antibody reduces disease severity in mice infected with Trypanosoma cruziQ39829243
CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditisQ40016348
Cardiac involvement is a constant finding in acute Chagas' disease: a clinical, parasitological and histopathological studyQ40649314
A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteinsQ40882932
Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruziQ41823109
In situ expression of regulatory cytokines by heart inflammatory cells in Chagas' disease patients with heart failureQ41849739
Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunityQ42114995
Nitric oxide synthase-2 modulates chemokine production by Trypanosoma cruzi-infected cardiac myocytesQ42152162
Modulation of autoimmunity by treatment of an infectious diseaseQ42432412
Are increased frequency of macrophage-like and natural killer (NK) cells, together with high levels of NKT and CD4+CD25high T cells balancing activated CD8+ T cells, the key to control Chagas' disease morbidity?Q42497203
Parasite persistence correlates with disease severity and localization in chronic Chagas' diseaseQ42605133
Th17 cells in inflammatory conditionsQ42976492
Cardiac damage induced by immunization with heat-killed Trypanosoma cruzi is not antibody mediatedQ44113294
CD4+CD25+Foxp3+ regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium yoelii infection in susceptible BALB/c mice.Q44235863
Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors. Functional and pathological implicationsQ44561352
Frequency of interferon- gamma -producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas diseaseQ44771953
Regulation of proinflammatory Th17 responses during Trypanosoma cruzi infection by IL-12 family cytokinesQ44973879
The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection.Q45339719
Foxp3+CD25(high) CD4+ regulatory T cells from indeterminate patients with Chagas disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity.Q45593876
The human macrophage mannose receptor is not a professional phagocytic receptorQ46378486
Administration of granulocyte colony-stimulating factor induces immunomodulation, recruitment of T regulatory cells, reduction of myocarditis and decrease of parasite load in a mouse model of chronic Chagas disease cardiomyopathyQ47733495
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.Q54139898
Potential role of CD4+CD25HIGH regulatory T cells in morbidity in Chagas diseaseQ56901414
Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and diseaseQ57203300
Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected miceQ58842504
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziQ58843169
The regulatory CD4+CD25+ T cells have a limited role on pathogenesis of infection with Trypanosoma cruziQ58844686
Role of Trypanosoma cruzi autoreactive T cells in the generation of cardiac pathologyQ58844932
Microvascular changes as a cause of chronic cardiomyopathy in Chagas' diseaseQ58845107
Chagasic patients with indeterminate clinical form of the disease have high frequencies of circulating CD3+CD16-CD56+ natural killer T cells and CD4+CD25High regulatory T lymphocytesQ58845519
Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' diseaseQ58845899
Antigen-specific Th1 but not Th2 cells provide protection from lethal Trypanosoma cruzi infection in miceQ58846523
CD4 Th1 but not Th2 clones efficiently activate macrophages to eliminate Trypanosoma cruzi through a nitric oxide dependent mechanismQ59387726
Phagocytosis of unopsonized zymosan by human monocyte-derived macrophages: maturation and inhibition by mannanQ69845125
Immunization with the C-terminal region of Trypanosoma cruzi ribosomal P1 and P2 proteins induces long-term duration cross-reactive antibodies with heart functional and structural alterations in young and aged miceQ73066943
Echocardiographic and Clinical Predictors of Mortality in Chronic Chagas' DiseaseQ73433484
Captopril prevents experimental autoimmune myocarditisQ73552878
Cruzipain induces autoimmune response against skeletal muscle and tissue damage in miceQ74199971
CD4+Foxp3+ regulatory T cells in the control of autoimmunity: in vivo veritasQ79623493
Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-betaQ80358435
Cardiac parasympathetic abnormalities: Cause or consequence of chagas heart disease?Q80818267
Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cellsQ82732264
P433issue3
P921main subjectChagas diseaseQ649558
P304page(s)1167-1178
P577publication date2015-01-11
P1433published inParasitology ResearchQ15755242
P1476titleDepletion of regulatory T cells decreases cardiac parasitosis and inflammation in experimental Chagas disease
P478volume114

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cites work (P2860)
Q40273147BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection.
Q47093622Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection.
Q38599837Immunity and immune modulation in Trypanosoma cruzi infection
Q56895331Interleukin 10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis
Q59136942Limited Foxp3 Regulatory T Cells Response During Acute Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8 T Cell Immunity
Q57789637Pathology and Pathogenesis of Chagas Heart Disease
Q54255041Regulatory Lymphoid and Myeloid Cells Determine the Cardiac Immunopathogenesis of Trypanosoma cruzi Infection.
Q58705710The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease
Q47162312Unconventional Pro-inflammatory CD4+ T Cell Response in B Cell-Deficient Mice Infected with Trypanosoma cruzi.
Q92471833Vaccines and the regulatory arm of the immune system. An overview from the Trypanosoma cruzi infection model

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