PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

article

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/35083076
P698PubMed publication ID11433301

P50authorHediye Erdjument-BromageQ25910537
Paul TempstQ25912123
Matthew A. CooperQ41772215
Karen E AndersonQ64677317
P2093author name stringJohn Coadwell
Keith Davidson
Andrew B. Holmes
Jan W. Thuring
Len R. Stephens
Chris D. Ellson
Edwin R. Chilvers
Phill T. Hawkins
Piers R. J. Gaffney
Stéphanie Gobert-Gosse
Ze-Yi Lim
P2860cites workp40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domainsQ24324646
Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?Q24674641
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gammaQ27629132
Use of mass spectrometric molecular weight information to identify proteins in sequence databasesQ28260483
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101Q28678835
Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometerQ30843617
Examination of micro-tip reversed-phase liquid chromatographic extraction of peptide pools for mass spectrometric analysisQ31943093
Molecular basis for Rac2 regulation of phagocyte NADPH oxidaseQ32063730
NADPH oxidase and the respiratory burstQ34391668
Impaired recruitment of the small GTPase rab7 correlates with the inhibition of phagosome maturation by Leishmania donovani promastigotes.Q40826573
The biochemical basis of the NADPH oxidase of phagocytes.Q40904508
Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation.Q42465157
Moving in mysterious waysQ59079333
Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analoguesQ68957878
P433issue7
P921main subjectcell biologyQ7141
P304page(s)679-682
P577publication date2001-06-12
P1433published inNature Cell BiologyQ1574111
P1476titlePtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox
P478volume3

Reverse relations

cites work (P2860)
Q35023800A multi-colour/multi-affinity marker set to visualize phosphoinositide dynamics in Arabidopsis.
Q42370259A new discrete dynamic model of ABA-induced stomatal closure predicts key feedback loops
Q37381703A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity.
Q44512445A new role of Pro-73 of p47phox in the activation of neutrophil NADPH oxidase
Q44283104A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase
Q30478913A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox
Q44440651A role for phosphatidylinositol 3-phosphate in abscisic acid-induced reactive oxygen species generation in guard cells
Q36446860APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex
Q30497702Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophages
Q28297425Activation and assembly of the NADPH oxidase: a structural perspective
Q40717916Activation of phosphoinositide 3-kinase gamma by Ras.
Q33948936Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate
Q42829265Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
Q27932927All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate.
Q57651388Analyzing phosphoinositides and their interacting proteins
Q28283086Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
Q28215817Architecture of the p40-p47-p67phox complex in the resting state of the NADPH oxidase. A central role for p67phox
Q29614500Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Q45264626Auxin-induced reactive oxygen species production requires the activation of phosphatidylinositol 3-kinase
Q28391506Basic principles and emerging concepts in the redox control of transcription factors
Q54369231Beclin-1-mediated autophagy protects spinal cord neurons against mechanical injury-induced apoptosis
Q24307993Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction
Q35794843Cellular and molecular interactions of phosphoinositides and peripheral proteins
Q40094185Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production
Q34548314Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases
Q26865657Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic
Q64077319Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities
Q34631859Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation
Q33360225Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway
Q27649974Crystal structures of PI3K-C2α PX domain indicate conformational change associated with ligand binding
Q24339429Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-Methyl-d-Aspartate Receptor 2C (NR2C)
Q34166131Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.
Q44854782Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase
Q44859194Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia
Q38257347Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins.
Q24338397Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains
Q36687961Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger.
Q24531264Endosomal localization and function of sorting nexin 1
Q44590783Eosinophil Major Basic Protein Stimulates Neutrophil Superoxide Production by a Class IA Phosphoinositide 3-Kinase and Protein Kinase C-ζ-Dependent Pathway
Q30478337Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization.
Q24305485Evidence for a role of SNX16 in regulating traffic between the early and later endosomal compartments
Q30484229Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
Q27643779Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding
Q34168289Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice
Q64946471Genetically encoded lipid biosensors
Q38256963Granule protein processing and regulated secretion in neutrophils
Q37121883Guard-cell signalling for hydrogen peroxide and abscisic acid
Q26778321Guidelines for the Use of Protein Domains in Acidic Phospholipid Imaging
Q37999286HemITAM signaling by CEACAM3, a human granulocyte receptor recognizing bacterial pathogens
Q28581772Hepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranes
Q40690529Hormone-regulated transepithelial Na+ transport in mammalian CCD cells requires SGK1 expression
Q41614016How a lipid mediates tumour suppression. Delivered on 29 June 2010 at the 35th FEBS Congress in Gothenburg, Sweden
Q37977162How phosphoinositide 3-phosphate controls growth downstream of amino acids and autophagy downstream of amino acid withdrawal
Q34357684Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region
Q79424032Hydrogen peroxide production is an early event during bicarbonate induced stomatal closure in abaxial epidermis of Arabidopsis
Q39316572Imaging macropinosomes during Shigella infections.
Q36168511Imaging phosphoinositide dynamics using GFP-tagged protein domains
Q38774879Immunoreceptors on neutrophils
Q50518557Inositol Polyphosphate 5-Phosphatase7 Regulates the Production of Reactive Oxygen Species and Salt Tolerance in Arabidopsis
Q28508182Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action
Q30160364Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding
Q50090782Investigation of the phosphatidylserine binding properties of the lipid biosensor, Lactadherin C2 (LactC2), in different membrane environments
Q44801081Involvement of reactive oxygen species in cardiotrophin-1-induced proliferation of cardiomyocytes differentiated from murine embryonic stem cells
Q47895048LC3-Associated Phagocytosis and Inflammation.
Q37117061Label-free electronic probing of nucleic acids and proteins at the nanoscale using the nanoneedle biosensor
Q52724932Lindane stimulates neutrophils by selectively activating phospholipase C and phosphoinositide-kinase activity
Q37101684Live cell imaging of phosphoinositides with expressed inositide binding protein domains
Q34453921Location, Location, Location: Membrane Targeting Directed by PX Domains
Q28506616Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
Q45099229Mechanism of membrane binding of the phospholipase D1 PX domain
Q36914141Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes.
Q26999431Membrane Trafficking and Phagosome Maturation During the Clearance of Apoptotic Cells
Q36103518Membrane binding domains
Q40674156Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox
Q96824783Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes
Q35609309Membrane recognition and targeting by lipid-binding domains
Q29614848Membrane recognition by phospholipid-binding domains
Q34429734Modular phosphoinositide-binding domains--their role in signalling and membrane trafficking.
Q38053953Molecular Analysis of Protein–Phosphoinositide Interactions
Q27930182Molecular mechanism of membrane docking by the Vam7p PX domain
Q50502730Monitoring Phospholipid Dynamics during Phagocytosis: Application of Genetically-Encoded Fluorescent Probes
Q30273585Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner.
Q24291963Myotubularin and MTMR2, Phosphatidylinositol 3-Phosphatases Mutated in Myotubular Myopathy and Type 4B Charcot-Marie-Tooth Disease
Q37265507NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology
Q27001094NADPH oxidases in heart failure: poachers or gamekeepers?
Q35296159NADPH oxidases: not just for leukocytes anymore!
Q38221176Neutrophils at work
Q36228786Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.
Q35065948Neutrophils with a license to kill: permeabilized, not stirred
Q27004060New insights into the regulation of neutrophil NADPH oxidase activity in the phagosome: a focus on the role of lipid and Ca(2+) signaling
Q37151978Nox enzymes in immune cells
Q34577042Nox2 is required for macrophage chemotaxis towards CSF-1.
Q34572888Nuclear phosphoinositides could bring FYVE alive.
Q57364236Oiling the wheels of the endocytic pathway
Q34743218Optical biosensors in drug discovery
Q34970933Organelle identity and the targeting of peripheral membrane proteins
Q38959357Oxidized phagosomal NOX2 complex is replenished from lysosomes.
Q24294423P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
Q24312088PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62
Q54527804PI3K signalling: the path to discovery and understanding
Q34195495PI3K: from the bench to the clinic and back
Q34389540PKB/AKT: functional insights from genetic models
Q34325281PX domains: attracted by phosphoinositides
Q24602890Phagosome maturation during the removal of apoptotic cells: receptors lead the way
Q46844334Phosphatidylinositol 3- and 4-phosphate modulate actin filament reorganization in guard cells of day flower
Q35842609Phosphatidylinositol 3-Kinase Plays a Vital Role in Regulation of Rice Seed Vigor via Altering NADPH Oxidase Activity
Q38315119Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells
Q39584074Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.
Q36462364Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain.
Q40047105Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase
Q34459677Phosphatidylinositol 3‐Kinase and the Control of Endosome Dynamics: New Players Defined by Structural Motifs
Q46294972Phosphoinositide Diversity, Distribution, and Effector Function: Stepping Out of the Box.
Q35573976Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation
Q35106866Phosphoinositide recognition domains
Q34659418Phosphoinositide-binding domains: Functional units for temporal and spatial regulation of intracellular signalling
Q33752616Phosphoinositide-incorporated lipid–protein nanodiscs: A tool for studying protein–lipid interactions
Q41838967Phosphoinositides and phagocytosis
Q24681540Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation
Q30156016Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase
Q28204861Phoxy lipids: revealing PX domains as phosphoinositide binding modules
Q38023138Plant cell division: ROS homeostasis is required
Q52644169Platelet Signaling Pathways and New Inhibitors
Q33375459Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase
Q35236004Polyphosphoinositide binding domains: Key to inositol lipid biology.
Q35573989Protein Targeting to Endosomes and Phagosomes via FYVE and PX Domains
Q38828211Protein trafficking in apicomplexan parasites: crossing the vacuolar Rubicon
Q28292379Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling
Q36764870PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis
Q30514916PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils
Q35065819PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation
Q39088749Quantifying lipid changes in various membrane compartments using lipid binding protein domains
Q43918731Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.
Q57915133Reactive Oxygen Species in Plant Development and Pathogen Defence
Q24349073Reactive oxygen species in the activation and regulation of intracellular signaling events
Q34456647Recognizing phosphatidylinositol 3-phosphate.
Q42447237Reduced expression of flavocytochrome b558, a component of the NADPH oxidase complex, in neutrophils from patients with myelodysplasia
Q28205154Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms
Q44135971Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase
Q28551125Role of an SNP in Alternative Splicing of Bovine NCF4 and Mastitis Susceptibility
Q41080044Role of nucleotides and phosphoinositides in the stability of electron and proton currents associated with the phagocytic NADPH oxidase.
Q35574000Roles of PI3K in Neutrophil Function
Q34560905Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
Q38291821Roles of phosphatidylinositol 3-kinase in root hair growth
Q30495822SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages
Q24306571SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1
Q24338384SNX25 regulates TGF-β signaling by enhancing the receptor degradation
Q90263746SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse
Q37732032Sequential activation of phosphatidylinositol 3-kinase, beta Pix, Rac1, and Nox1 in growth factor-induced production of H2O2.
Q33477573Signal transduction profiling using label-free biosensors
Q28283677Signaling by the phosphoinositide 3-kinase family in immune cells
Q30493800Signaling components of redox active endosomes: the redoxosomes.
Q24338519Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
Q58754146Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin
Q37597288Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1.
Q28216490Sorting out the cellular functions of sorting nexins
Q30014849Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction
Q39466811Stable accumulation of p67phox at the phagosomal membrane and ROS production within the phagosome
Q27646147Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity
Q54453781Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha
Q47651331Structural basis of membrane targeting by the Phox homology domain of cytokine-independent survival kinase (CISK-PX).
Q34498078Structural genomics and signaling domains.
Q28282131Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
Q37983211Studying Lipids Involved in the Endosomal Pathway
Q42427499Subcellular localisation of the p40phox component of NADPH oxidase involves direct interactions between the Phox homology domain and F-actin
Q34089143Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes
Q30491877Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases
Q27349319The FbaB-type fibronectin-binding protein of Streptococcus pyogenes promotes specific invasion into endothelial cells
Q40105885The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase
Q28206438The NADPH Oxidase Components p47phox and p40phox Bind to Moesin through Their PX Domain
Q35828194The NADPH oxidase of professional phagocytes--prototype of the NOX electron transport chain systems
Q55160467The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells
Q34214128The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
Q60944020The Phosphoinositide Kinase PIKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation
Q38870984The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation
Q24533547The Phox homology (PX) domain, a new player in phosphoinositide signalling
Q21091096The SNX-PX-BAR family in macropinocytosis: the regulation of macropinosome formation by SNX-PX-BAR proteins
Q48216958The VPS34 PI3K negatively regulates RAB-5 during endosome maturation
Q28180409The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells
Q30165057The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.
Q24533882The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2
Q35187522The class II phosphatidylinositol 3-phosphate kinase PIK3C2A promotes Shigella flexneri dissemination through formation of vacuole-like protrusions
Q24291846The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate
Q34389525The endocytic pathway: a mosaic of domains
Q37783925The many roles of NOX2 NADPH oxidase-derived ROS in immunity
Q43812779The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides.
Q44177583The p47phox PX domain: two heads are better than one!
Q27933451The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae
Q30159700The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis
Q28219187The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation
Q24673655The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain
Q28186713The role of PI3K in immune cells
Q35977011The role of TaCHP in salt stress responsive pathways
Q34542019Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling
Q26825722Trafficking regulation of proteins in Alzheimer's disease
Q28285651Translation of the phosphoinositide code by PI effectors
Q54211356Tuberculosis and the art of macrophage manipulation.
Q27681186Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy
Q36325071Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes
Q36808725Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains.
Q35075139Visualization of cellular phosphoinositide pools with GFP-fused protein-domains
Q47235913Vps34 and the Armus/TBC-2 Rab GAPs: Putting the brakes on the endosomal Rab5 and Rab7 GTPases
Q34316033agr-Dependent Interactions of Staphylococcus aureus USA300 with Human Polymorphonuclear Neutrophils
Q33194626cDNA cloning and characterization of a novel SNX gene differentially expressed in previtellogenic oocytes of gibel carp
Q40771740mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
Q24292834p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox

Search more.