Nuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing in Drosophila Ovaries

scientific article published on 07 February 2020

Nuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing in Drosophila Ovaries is …
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scholarly articleQ13442814

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P356DOI10.3390/IJMS21031119
P932PMC publication ID7037970
P698PubMed publication ID32046213

P2093author name stringAnastasia D Stolyarenko
P2860cites workMPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturationQ24300437
The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanismQ24322559
ATP-dependent human RISC assembly pathwaysQ24336545
Functions of the exosome in rRNA, snoRNA and snRNA synthesisQ24529845
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysQ24564402
A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewalQ24595550
An endogenous small interfering RNA pathway in DrosophilaQ24623214
A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcriptsQ24658122
Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germlineQ24791717
Evidence for rolling circle replication of tandem genes in DrosophilaQ24812435
Production of small RNAs by mammalian DicerQ26751455
Breaking bad: R-loops and genome integrityQ26858910
Renaissance of mammalian endogenous RNAiQ26859171
The impact of transposable elements in genome evolution and genetic instability and their implications in various diseasesQ27012919
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesisQ27334993
Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae.Q27929795
The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleasesQ27930922
The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2Q27931464
Polyadenylation of rRNA in Saccharomyces cerevisiae.Q27932222
R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrityQ27933182
The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding proteinQ27934035
Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease ActivitiesQ27934389
Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs.Q27935348
Nuclear RNA surveillance in Saccharomyces cerevisiae: Trf4p-dependent polyadenylation of nascent hypomethylated tRNA and an aberrant form of 5S rRNA.Q27936202
Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number controlQ27937988
Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S pre-rRNA processingQ27939136
Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiaeQ27939499
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cellsQ28142394
Human RNase III is a 160-kDa protein involved in preribosomal RNA processingQ28144074
Extrachromosomal circular DNA of tandemly repeated genomic sequences in DrosophilaQ28178271
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesisQ28213010
Biogenesis and germline functions of piRNAsQ28258430
Endogenous siRNAs derived from transposons and mRNAs in Drosophila somatic cellsQ28276069
A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in DrosophilaQ28290099
Discrete small RNA-generating loci as master regulators of transposon activity in DrosophilaQ28292093
Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profileQ28511307
A genome-wide RNAi screen draws a genetic framework for transposon control and primary piRNA biogenesis in DrosophilaQ28673148
The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stressQ28854588
Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin stateQ29544165
A distinct small RNA pathway silences selfish genetic elements in the germlineQ29614717
Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathwaysQ29618467
Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineageQ30583079
Heterogeneity in polyadenylation cleavage sites in mammalian mRNA sequences: implications for SAGE analysis.Q30663306
Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genesQ47071078
Noncoding RNA Surveillance: The Ends Justify the MeansQ47663764
Piwi Is Required during Drosophila Embryogenesis to License Dual-Strand piRNA Clusters for Transposon Repression in Adult OvariesQ47777981
Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPasesQ48069855
Transcriptional and chromatin changes accompanying de novo formation of transgenic piRNA clusters.Q48191826
A new layer of rRNA regulation by small interference RNAs and the nuclear RNAi pathway.Q48236179
Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome.Q48236921
Accumulation of RNA on chromatin disrupts heterochromatic silencingQ49576014
Identifying small RNAs derived from maternal- and somatic-type rRNAs in Zebrafish DevelopmentQ50098210
Participation of the piRNA pathway in recruiting a component of RNA polymerase I transcription initiation complex to germline cell nucleoliQ50110001
Maternal piRNAs Are Essential for Germline Development following De Novo Establishment of Endo-siRNAs in Caenorhabditis elegansQ50715522
Alternative pathways in the processing of ribosomal RNA precursor in Drosophila melanogasterQ52526052
siRNAs and piRNAs Collaborate for Transposon Control in the Two-Spotted Spider Mite.Q52573434
RNA surveillance by the nuclear RNA exosome: mechanisms and significance.Q52599402
The interplay of transposon silencing genes in the Drosophila melanogaster germlineQ52728229
PIWI protein as a nucleolus visitor in Drosophila melanogasterQ52800858
Surveillance-ready transcription: nuclear RNA decay as a default fate.Q55341657
A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most AnimalsQ56887532
Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNAQ57050016
The somatic piRNA pathway controls germline transposition over generationsQ57472098
Diverse RNA interference strategies in early-branching metazoansQ58078905
The antiviral piRNA response in mosquitoes?Q58104350
Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeastQ58778006
From “Cellular” RNA to “Smart” RNA: Multiple Roles of RNA in Genome Stability and BeyondQ58862336
Small Non-Coding RNAs Derived From Eukaryotic Ribosomal RNAQ64230175
Exonuclease domain mutants of yeast DIS3 display genome instabilityQ64255778
Next-generation sequencing reveals two populations of damage-induced small RNAs at endogenous DNA double-strand breaksQ64388860
Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.Q64883979
Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protectionQ80195998
RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencingQ80355985
A new role of the rDNA and nucleolus in the nucleus--rDNA instability maintains genome integrityQ80754881
The polyadenylation factor CPSF-73 is involved in histone-pre-mRNA processingQ81327465
Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosomeQ81650339
Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genomeQ81886031
An Argonaute Protein Directs Nuclear Xrn2 FunctionQ85582628
Quantitative Northern Blot Analysis of Mammalian rRNA ProcessingQ88233212
Rat1 and Xrn2: The Diverse Functions of the Nuclear Rat1/Xrn2 ExonucleaseQ89409711
The nucleolar transcriptome regulates Piwi shuttling between the nucleolus and the nucleoplasmQ90419867
Keeping ribosomal DNA intact: a repeating challengeQ90575517
Stress-induced nuclear depletion of Entamoeba histolytica 3'-5' exoribonuclease EhRrp6 and its role in growth and erythrophagocytosisQ91254037
Nuclear Ccr4-Not mediates the degradation of telomeric and transposon transcripts at chromatin in the Drosophila germlineQ91277028
PIWI pathway against viruses in insectsQ92651046
Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptomeQ92963555
A deeply conserved, noncanonical miRNA hosted by ribosomal DNA.Q35113562
Molecular paleontology of transposable elements in the Drosophila melanogaster genomeQ35143591
Mechanism of siRNA production from repetitive DNAQ35173293
An overview of pre-ribosomal RNA processing in eukaryotesQ35180630
Signaling to p53: ribosomal proteins find their way.Q35206381
RNA-mediated epigenetic regulation of gene expressionQ35223649
Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiaeQ35262494
Separation of stem cell maintenance and transposon silencing functions of Piwi proteinQ35558625
TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathwayQ35618796
A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage.Q35750783
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.Q35779932
Small RNA in the nucleus: the RNA-chromatin ping-pongQ35935955
piRNAs and piRNA-Dependent siRNAs Protect Conserved and Essential C. elegans Genes from Misrouting into the RNAi PathwayQ35998286
MIWI2 and MILI Have Differential Effects on piRNA Biogenesis and DNA MethylationQ36011085
piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire.Q36032461
RNA helicase Spn-E is required to maintain Aub and AGO3 protein levels for piRNA silencing in the germline of DrosophilaQ36056335
Telomeric repeat silencing in germ cells is essential for early development in Drosophila.Q36160616
The Cochaperone Shutdown Defines a Group of Biogenesis Factors Essential for All piRNA Populations in DrosophilaQ36296128
Paramutation in Drosophila Requires Both Nuclear and Cytoplasmic Actors of the piRNA Pathway and Induces Cis-spreading of piRNA ProductionQ36365213
Global role for polyadenylation-assisted nuclear RNA degradation in posttranscriptional gene silencingQ36421393
Gene regulation by non-coding RNAsQ36487134
RNAi triggered by specialized machinery silences developmental genes and retrotransposonsQ36561712
Apoptotic signals induce specific degradation of ribosomal RNA in yeastQ36676485
tRNA cleavage is a conserved response to oxidative stress in eukaryotesQ36909679
A Transcriptome-wide RNAi Screen in the Drosophila Ovary Reveals Factors of the Germline piRNA PathwayQ37047745
Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA PrecursorsQ37165546
Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAsQ37352034
RNA Quality Control as a Key to Suppressing RNA Silencing of Endogenous Genes in PlantsQ37441871
The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila.Q37482054
Retrotransposable elements R1 and R2 interrupt the rRNA genes of most insectsQ37482459
Genetic and mechanistic diversity of piRNA 3'-end formationQ37511977
Noisy silence: non-coding RNA and heterochromatin formation at repetitive elementsQ37591541
5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpointQ37592131
The repetitive DNA content of eukaryotic genomes.Q38023670
DNA damage sensing by the ATM and ATR kinases.Q38134064
Late steps in the maturation of Drosophila 26 S ribosomal RNA: generation of 5-8 S and 2 S RNAs by cleavages occurring in the cytoplasmQ38359802
Insertion of an Alu element in a lncRNA leads to primate-specific modulation of alternative splicingQ38735185
RNA interference in the Colorado potato beetle, Leptinotarsa decemlineata: Identification of key contributors.Q38740966
Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of RepeatsQ38786761
Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAsQ39094256
Functional analysis of the RNAi response in ovary-derived silkmoth Bm5 cellsQ39152696
Sequence and secondary structure of Drosophila melanogaster 5.8S and 2S rRNAs and of the processing site between themQ39706069
Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunitsQ39773502
A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila.Q39790098
qiRNA is a new type of small interfering RNA induced by DNA damage.Q40190642
Repeated genes in eukaryotesQ40289317
The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA PathwayQ40681550
Distribution of split 5.8S ribosomal RNA in DipteraQ41088755
Inducible expression of the 2-5A synthetase/RNase L system results in inhibition of vaccinia virus replicationQ41135027
Structure and processing of precursor 5 S RNA in Drosophila melanogasterQ41379324
The effects of stem I and loop A on the processing of 5 S rRNA from Drosophila melanogasterQ41593819
Why does insect RNA look degraded?Q41670062
A Tetrahymena Piwi Bound to Mature tRNA 3′ Fragments Activates the Exonuclease Xrn2 for RNA Processing in the NucleusQ41807335
Rapid cytoplasmic turnover of yeast ribosomes in response to rapamycin inhibition of TOR.Q41893438
Evolution of ribosomal RNA gene copy number on the sex chromosomes of Drosophila melanogasterQ41899111
Retrotransposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germlineQ42056098
Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA.Q42152387
Transcription termination and RNA degradation contribute to silencing of RNA polymerase II transcription within heterochromatinQ42524806
Proliferation of Double-Strand Break-Resistant Polyploid Cells Requires Drosophila FANCD2.Q42735314
Noncoding Transcripts in Sense and Antisense Orientation Regulate the Epigenetic State of Ribosomal RNA GenesQ42742473
A photographic study of development in the living embryo of Drosophila melanogasterQ43675550
piRNA Biogenesis in Drosophila melanogasterQ46301988
Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.Q46987001
The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specificationQ47071009
Quelling targets the rDNA locus and functions in rDNA copy number controlQ33412565
The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosomeQ33496770
A broadly conserved pathway generates 3'UTR-directed primary piRNAsQ33614944
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stabilityQ33641829
Transposable elements in DrosophilaQ33725396
Small RNA Pathways That Protect the Somatic GenomeQ33754789
Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi.Q33762828
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovaryQ33901565
Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphologyQ33958832
DNA replication initiation patterns and spatial dynamics of the human ribosomal RNA gene lociQ33978073
Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage responseQ34001721
Eukaryotic 5S rRNA biogenesisQ34028735
Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cellsQ34165710
A genome-scale shRNA resource for transgenic RNAi in DrosophilaQ34175440
Nucleolar stress with and without p53.Q34183329
FlyMove--a new way to look at development of DrosophilaQ34205111
Functional characterization of the Drosophila MRP (mitochondrial RNA processing) RNA geneQ34210384
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in DrosophilaQ34211342
Heterotypic piRNA Ping-Pong Requires Qin, a Protein with Both E3 Ligase and Tudor DomainsQ34234176
Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in DrosophilaQ34288988
Profiling and identification of small rDNA-derived RNAs and their potential biological functionsQ34328342
Incomplete replication generates somatic DNA alterations within Drosophila polytene salivary gland cellsQ34342909
Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosomeQ34366308
Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis.Q34407483
Noncoding RNA. piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesisQ34476509
Noncoding RNA. piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA productionQ34476516
The Yb body, a major site for Piwi-associated RNA biogenesis and a gateway for Piwi expression and transport to the nucleus in somatic cellsQ34537010
Dicer promotes transcription termination at sites of replication stress to maintain genome stabilityQ34567609
zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germlineQ34633591
5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decayQ34699786
The transcriptional activity of RNA polymerase I is a key determinant for the level of all ribosome componentsQ34958821
piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germlineQ34995447
Depletion of key protein components of the RISC pathway impairs pre-ribosomal RNA processingQ35040997
Euchromatic transposon insertions trigger production of novel Pi- and endo-siRNAs at the target sites in the drosophila germlineQ35091284
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P577publication date2020-02-07
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleNuclear Argonaute Piwi Gene Mutation Affects rRNA by Inducing rRNA Fragment Accumulation, Antisense Expression, and Defective Processing in Drosophila Ovaries
P478volume21

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