Widespread RNA editing dysregulation in brains from autistic individuals

scientific article published on 17 December 2018

Widespread RNA editing dysregulation in brains from autistic individuals is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41593-018-0287-X
P932PMC publication ID6375307
P698PubMed publication ID30559470

P50authorDaniel GeschwindQ18631415
Xinshu XiaoQ55154862
Eric Van NostrandQ79781519
Changhoon LeeQ87045189
Gene W YeoQ89518734
P2093author name stringGokul Ramaswami
Randi J Hagerman
Verónica Martínez-Cerdeño
Hyun-Ik Jun
Jae Hoon Bahn
Gabriel A Pratt
Stephen S Tran
Thai B Nguyen
Adel Azghadi
Yun-Hua E Hsiao
P2860cites workWGCNA: an R package for weighted correlation network analysisQ21284194
The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2Q24303859
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identitiesQ24617969
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autismQ24631425
Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the LifespanQ26771768
A-to-I editing of coding and non-coding RNAs by ADARsQ26773402
Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum DisordersQ26796321
Advances and challenges in the detection of transcriptome-wide protein-RNA interactions.Q38635719
Multifarious Functions of the Fragile X Mental Retardation ProteinQ38639448
RNA Editing: A Contributor to Neuronal Dynamics in the Mammalian Brain.Q38709262
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wideQ38796653
Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder.Q38804936
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autismQ39129795
A highly conserved program of neuronal microexons is misregulated in autistic brainsQ39403790
Accurate identification of A-to-I RNA editing in human by transcriptome sequencingQ39465344
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.Q40154871
The role of the prefrontal cortex in higher cognitive functionsQ40918023
Integrative functional genomic analyses implicate specific molecular pathways and circuits in autismQ41976669
Serotonin neuron abnormalities in the BTBR mouse model of autism.Q47137996
Gene-set analysis shows association between FMRP targets and autism spectrum disorderQ47745129
Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B.Q48242571
Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells.Q48306723
Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.Q48321111
Evolutionarily conserved A-to-I editing increases protein stability of the alternative splicing factor Nova1.Q48704407
The inv dup(15) syndrome: a clinically recognizable syndrome with altered behavior, mental retardation, and epilepsy.Q52002536
Adenosine-to-inosine RNA editing and human diseaseQ26853110
The role of glutamate and its receptors in autism and the use of glutamate receptor antagonists in treatmentQ26998975
Advancing the understanding of autism disease mechanisms through geneticsQ28069757
FMRP targets distinct mRNA sequence elements to regulate protein expressionQ28117931
Evolution of the neocortex: a perspective from developmental biologyQ28258984
REDIportal: a comprehensive database of A-to-I RNA editing events in humansQ28584443
RASER: reads aligner for SNPs and editing sites of RNAQ28603473
A genome-wide map of hyper-edited RNA reveals numerous new sitesQ28652190
Sigma: strain-level inference of genomes from metagenomic analysis for biosurveillanceQ28652492
Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathwaysQ28652541
Mammalian conserved ADAR targets comprise only a small fragment of the human editosomeQ28658383
SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs)Q28661318
De Novo Gene Disruptions in Children on the Autistic SpectrumQ29394534
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing dataQ29547161
Systematic identification of abundant A-to-I editing sites in the human transcriptomeQ29619584
Eigengene networks for studying the relationships between co-expression modulesQ33306760
Convergence of genes and cellular pathways dysregulated in autism spectrum disordersQ33794546
IQ in children with autism spectrum disorders: data from the Special Needs and Autism Project (SNAP).Q33805626
Fragile X and autism: Intertwined at the molecular level leading to targeted treatmentsQ34198650
The fragile X syndrome-autism comorbidity: what do we really know?Q34349515
Comparative RNA editing in autistic and neurotypical cerebella.Q34368185
Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R.Q34714933
Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autismQ34731122
circlize Implements and enhances circular visualization in R.Q35188401
The MEME SuiteQ35810173
Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP).Q35971227
Disruption of an Evolutionarily Novel Synaptic Expression Pattern in AutismQ36148664
Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain studyQ36371192
Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's diseaseQ36461925
Resources for the Comprehensive Discovery of Functional RNA ElementsQ36820981
Identification of a distinct developmental and behavioral profile in children with Dup15q syndromeQ36876026
Analysis and design of RNA sequencing experiments for identifying RNA editing and other single-nucleotide variantsQ36932859
The Ensembl gene annotation systemQ37033476
Altered proliferation and networks in neural cells derived from idiopathic autistic individualsQ37562213
Dynamic regulation of RNA editing in human brain development and diseaseQ38445507
P4510describes a project that usesggplot2Q326489
ImageJQ1659584
P433issue1
P304page(s)25-36
P577publication date2018-12-17
P1433published inNature NeuroscienceQ1535359
P1476titleWidespread RNA editing dysregulation in brains from autistic individuals
P478volume22

Reverse relations

cites work (P2860)
Q64063088Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA
Q100945954Chronic bryostatin-1 rescues autistic and cognitive phenotypes in the fragile X mice
Q89477414Dietary Approaches to the Management of Autism Spectrum Disorders
Q64244182Dysregulated Ca-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome
Q93087888Genetic Causes and Modifiers of Autism Spectrum Disorder
Q100737121Genetic association of FMRP targets with psychiatric disorders
Q94521621Genome-wide association study of emotional empathy in children
Q90860152Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity
Q90370422Identification of FMR1-regulated molecular networks in human neurodevelopment
Q100693867Increased RNA editing in maternal immune activation model of neurodevelopmental disease
Q93040388Investigating RNA editing in deep transcriptome datasets with REDItools and REDIportal
Q90640178Quantifying RNA Editing in Deep Transcriptome Datasets
Q89935051Selective Enrichment of A-to-I Edited Transcripts from Cellular RNA Using Endonuclease V
Q91798023The majority of A-to-I RNA editing is not required for mammalian homeostasis
Q90201861mountainClimber Identifies Alternative Transcription Start and Polyadenylation Sites in RNA-Seq

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