Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions

scientific article published on 23 July 2009

Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1031389085
P356DOI10.1186/GB-2009-10-7-R80
P2888exact matchhttps://scigraph.springernature.com/pub.10.1186/gb-2009-10-7-r80
P932PMC publication ID2728534
P698PubMed publication ID19627575
P5875ResearchGate publication ID26690896

P50authorMichael B. EisenQ3308179
Jingyi Jessica LiQ57003057
Peter J. BickelQ7174850
P2093author name stringMark D Biggin
Xiao-Yong Li
James B Brown
David W Knowles
Aaron Hechmer
Brandi P Grondona
Hou Cheng Chu
Lisa Simirenko
Lucy Zeng
Mark Stapleton
Soile V E Keränen
Stewart MacArthur
P2860cites workExpression, modification, and localization of the fushi tarazu protein in Drosophila embryos.Q54744440
The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotesQ66894591
The snail gene required for mesoderm formation in Drosophila is expressed dynamically in derivatives of all three germ layersQ67956619
Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryoQ68000583
Chromatin structure mapping in vivo using methyltransferasesQ71747800
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectQ21061203
Transcription factors bind thousands of active and inactive regions in the Drosophila blastodermQ21563555
Gene ontology: tool for the unification of biologyQ23781406
Core transcriptional regulatory circuitry in human embryonic stem cellsQ24322016
Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genomeQ24530466
Foxp3 occupancy and regulation of key target genes during T-cell stimulationQ24623384
Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscuraQ24801531
Transcriptional control in the segmentation gene network of DrosophilaQ24803742
WebLogo: A Sequence Logo GeneratorQ27860646
Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAsQ28246401
Mutations affecting segment number and polarity in DrosophilaQ28273492
An initial blueprint for myogenic differentiationQ28588060
Genome-wide mapping of in vivo protein-DNA interactionsQ29547162
A gene complex controlling segmentation in DrosophilaQ29547506
A global map of p53 transcription-factor binding sites in the human genomeQ29614400
Transcription factors: structural families and principles of DNA recognitionQ29615317
Transcription regulation and animal diversityQ29618752
The daughterless gene product in Drosophila is a nuclear protein that is broadly expressed throughout the organism during developmentQ30466688
daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryoQ46037990
Silencers and domains of generalized repressionQ46090173
dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryoQ46340431
The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP familyQ46961403
The Drosophila fish-hook gene encodes a HMG domain protein essential for segmentation and CNS developmentQ47070101
The Dichaete gene of Drosophila melanogaster encodes a SOX-domain protein required for embryonic segmentation.Q47070144
Three maternal coordinate systems cooperate in the patterning of the Drosophila head.Q47070235
Establishing neuroblast-specific gene expression in the Drosophila CNS: huckebein is activated by Wingless and Hedgehog and repressed by Engrailed and Gooseberry.Q47070443
The control of cell fate along the dorsal-ventral axis of the Drosophila embryo.Q47071328
Analysis of Krüppel protein distribution during early Drosophila development reveals posttranscriptional regulationQ47071842
Interactions of the Drosophila gap gene giant with maternal and zygotic pattern-forming genesQ47071847
Eve and ftz regulate a wide array of genes in blastoderm embryos: the selector homeoproteins directly or indirectly regulate most genes in DrosophilaQ47071953
Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses.Q47072118
Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1.Q47072347
The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous systemQ47072448
Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryoQ47577828
Unfolding the mysteries of heterochromatin.Q48018648
Drosophila Paired regulates late even-skipped expression through a composite binding site for the paired domain and the homeodomain.Q48060768
A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling.Q48070213
The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factorsQ48172084
Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its functionQ48280400
Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays.Q50725987
Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis.Q52171808
In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product.Q52200200
Positioning adjacent pair-rule stripes in the posterior Drosophila embryoQ52214149
The Drosophila segmentation gene runt has an extended cis-regulatory region that is required for vital expression at other stages of developmentQ52229541
Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins.Q52252525
Control and function of terminal gap gene activity in the posterior pole region of the Drosophila embryoQ52445677
Spatial regulation of the gap gene giant during Drosophila development.Q52446989
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila.Q52454014
A molecular gradient in early Drosophila embryos and its role in specifying the body pattern.Q52456264
Localization of the fushi tarazu protein during Drosophila embryogenesis.Q52457512
Changing rates of DNA and RNA synthesis in Drosophila embryosQ52516271
Interacting functions of snail, twist and huckebein during the early development of germ layers in Drosophila.Q52542281
The effects of selection against spurious transcription factor binding sites.Q52950810
Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipelineQ33267397
Accessibility of transcriptionally inactive genes is specifically reduced at homeoprotein-DNA binding sites in DrosophilaQ33616371
A comparison of in vivo and in vitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryosQ33890600
Non-specific DNA binding of genome regulating proteins as a biological control mechanism: I. The lac operon: equilibrium aspectsQ34214782
The eve stripe 2 enhancer employs multiple modes of transcriptional synergyQ34371968
Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryoQ34378718
Transcriptional regulation in Drosophila: the post-genome challengeQ34495575
A gradient of bicoid protein in Drosophila embryosQ34687844
REDfly 2.0: an integrated database of cis-regulatory modules and transcription factor binding sites in DrosophilaQ34718350
Hotspots of transcription factor colocalization in the genome of Drosophila melanogasterQ35033165
Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamicsQ35629798
A core transcriptional network for early mesoderm development in Drosophila melanogasterQ35649396
Protein/DNA architecture of the DNase I hypersensitive region of the Drosophila hsp26 promoterQ35984426
Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cellsQ36103645
Genomic regulatory networks and animal developmentQ36273945
Global analysis of patterns of gene expression during Drosophila embryogenesisQ36570645
Gap gene properties of the pair-rule gene runt during Drosophila segmentationQ36736085
The origin of pattern and polarity in the Drosophila embryoQ36749988
Transcriptional regulatory networks in embryonic stem cellsQ37331007
DNA binding specificity of two homeodomain proteins in vitro and in Drosophila embryos.Q37671170
Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryoQ38304339
Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genomeQ38314358
Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarraysQ38319977
Gene regulatory functions of Drosophila fish-hook, a high mobility group domain Sox proteinQ38336749
Transcription factor access to chromatinQ39721189
Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cellsQ40190617
Compilation of vertebrate-encoded transcription factorsQ40411319
Autoregulatory and gap gene response elements of the even-skipped promoter of DrosophilaQ40817691
A novel spatial transcription pattern associated with the segmentation gene, giant, of DrosophilaQ40817942
The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signalingQ41033122
Regulation and function of the terminal gap gene huckebein in the Drosophila blastoderm.Q41059868
cis-acting control elements for Krüppel expression in the Drosophila embryoQ41242734
From gradients to stripes in Drosophila embryogenesis: filling in the gapsQ41279366
Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos.Q41454917
Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradientsQ41967488
Mapping the chromosomal targets of STAT1 by Sequence Tag Analysis of Genomic Enrichment (STAGE).Q41977742
Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements.Q42573541
Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryosQ42734921
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamilyQ43983015
A quantitative spatiotemporal atlas of gene expression in the Drosophila blastodermQ44427883
Gradients of Krüppel and knirps gene products direct pair-rule gene stripe patterning in the posterior region of the Drosophila embryoQ45287412
Krüppel requirement for knirps enhancement reflects overlapping gap gene activities in the Drosophila embryoQ45757474
P433issue7
P921main subjectDrosophilaQ312154
P304page(s)R80
P577publication date2009-07-23
P1433published inGenome BiologyQ5533480
P1476titleDevelopmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
P478volume10

Reverse relations

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