Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence

scientific article (publication date: 6 December 2011)

Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1044859878
P356DOI10.1038/NRG3095
P3181OpenCitations bibliographic resource ID475985
P698PubMed publication ID22143240
P5875ResearchGate publication ID51854348

P50authorGizem KalayQ82814587
P2093author name stringPatricia J Wittkopp
P2860cites workEvolution of yellow gene regulation and pigmentation in Drosophila.Q52113964
Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements.Q52548865
Regulatory changes underlying expression differences within and between Drosophila species.Q52688606
The evolution of gene regulation underlies a morphological difference between two Drosophila sister species.Q52689226
Evolutionary Divergence and Convergence in ProteinsQ56689213
De novo genesis of enhancers in vertebratesQ21145759
Does positive selection drive transcription factor binding site turnover? A test with Drosophila cis-regulatory modulesQ21563386
Functional evolution of a cis-regulatory moduleQ21563626
Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolutionQ22065751
Species-specific transcription in mice carrying human chromosome 21Q22065859
Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor bindingQ22065896
Fundamental concepts in genetics: Effective population size and patterns of molecular evolution and variationQ22122006
The genetic theory of adaptation: a brief historyQ22122021
Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancerQ24623538
Human-specific loss of regulatory DNA and the evolution of human-specific traitsQ24625593
The UCSC Genome Browser database: update 2011Q24625811
Regulatory divergence modifies limb length between mammalsQ24677153
Simple and highly efficient BAC recombineering using galK selectionQ24794075
Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscuraQ24801531
Reverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphismQ24816103
Big genomes facilitate the comparative identification of regulatory elementsQ27350595
Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological EvolutionQ28111693
Evolutionary changes in cis and trans gene regulationQ47259060
A gene-centered C. elegans protein-DNA interaction networkQ47594680
Transgenic tools for members of the genus Drosophila with sequenced genomes.Q47603650
Regulatory evolution of shavenbaby/ovo underlies multiple cases of morphological parallelismQ47673873
Intraspecific polymorphism to interspecific divergence: genetics of pigmentation in DrosophilaQ48067183
Detection of regulatory variation in mouse genes.Q48456623
Comment on "Human-specific gain of function in a developmental enhancer".Q51941098
Evolution at two levels in humans and chimpanzeesQ28141105
ChIP-seq accurately predicts tissue-specific activity of enhancersQ28235102
Repeated morphological evolution through cis-regulatory changes in a pleiotropic geneQ28235451
Gene Regulation for Higher Cells: A TheoryQ28256064
The evolutionary significance of cis-regulatory mutationsQ28288545
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in DrosophilaQ28305701
Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila speciesQ28473313
Rapid evolution of sex pheromone-producing enzyme expression in DrosophilaQ28475814
TRANSFAC: transcriptional regulation, from patterns to profilesQ29547394
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin allelesQ29615004
The locus of evolution: evo devo and the genetics of adaptationQ29615067
A distal enhancer and an ultraconserved exon are derived from a novel retroposonQ29616555
Identification of functional elements and regulatory circuits by Drosophila modENCODEQ29617551
Strong selective sweep associated with a transposon insertion in Drosophila simulans.Q30336352
The evolution of combinatorial gene regulation in fungiQ33321398
Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservationQ33347127
Alignment and prediction of cis-regulatory modules based on a probabilistic model of evolutionQ33419102
Nomadic enhancers: tissue-specific cis-regulatory elements of yellow have divergent genomic positions among Drosophila speciesQ33769587
Mutations and quantitative genetic variation: lessons from DrosophilaQ33856649
Regulatory divergence in Drosophila revealed by mRNA-seq.Q33881371
Natural selection on cis and trans regulation in yeastsQ33881377
Evidence for stabilizing selection in a eukaryotic enhancer element.Q33890254
Long-range control of gene expression: emerging mechanisms and disruption in diseaseQ33938801
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypesQ33990273
Enhancer function: new insights into the regulation of tissue-specific gene expressionQ34025898
Variation in transcription factor binding among humansQ34105133
Shadow enhancers foster robustness of Drosophila gastrulationQ34134393
Transcriptional enhancers in animal development and evolutionQ34137394
Phenomics: the next challengeQ34150453
Evidence for redundancy but not trans factor-cis element coevolution in the regulation of Drosophila Yp genesQ34607100
The signature of positive selection at randomly chosen loci.Q34614687
Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31Q34644225
Divergence of transcription factor binding sites across related yeast speciesQ34661726
Evolutionary origin of a novel gene expression pattern through co-option of the latent activities of existing regulatory sequencesQ35064208
Rapid evolutionary rewiring of a structurally constrained eye enhancerQ35127076
Morphological evolution caused by many subtle-effect substitutions in regulatory DNA.Q35207592
Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Drosophila melanogaster insecticide resistance gene Cyp6g1Q35730151
Using reporter genes to study cis-regulatory elementsQ35969895
Transposable elements as sources of variation in animals and plantsQ36010477
Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.Q36276913
New technologies, new findings, and new concepts in the study of vertebrate cis-regulatory sequencesQ36361716
Evolution of cis-regulatory sequence and function in DipteraQ36540447
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferencesQ36865636
The regulation and evolution of a genetic switch controlling sexually dimorphic traits in DrosophilaQ37002213
Convergence and parallelism reconsidered: what have we learned about the genetics of adaptation?Q37005588
The loci of evolution: how predictable is genetic evolution?Q37035424
Functional and mechanistic diversity of distal transcription enhancersQ37091409
The genetic basis of adaptive pigmentation variation in Drosophila melanogasterQ37115323
Human-specific gain of function in a developmental enhancerQ37135530
Resurrecting the role of transcription factor change in developmental evolution.Q37194983
Conservation of enhancer location in divergent insectsQ37321103
TATA box polymorphisms in human gene promoters and associated hereditary pathologies.Q37408294
Comparative genomics of gene regulation-conservation and divergence of cis-regulatory information.Q37632796
Conserved expression without conserved regulatory sequence: the more things change, the more they stay the sameQ37677317
The art of reporter proteins in science: past, present and future applicationsQ37776029
Transcription factor binding variation in the evolution of gene regulationQ37791728
Determining the specificity of protein-DNA interactionsQ37793836
Sequencing breakthroughs for genomic ecology and evolutionary biologyQ37876496
Shadow enhancers as a source of evolutionary noveltyQ38287743
A systems approach to measuring the binding energy landscapes of transcription factorsQ38305871
Loss-of-function mutation in a repressor module of human-specifically activated enhancer HACNS1.Q38331649
Genetic analysis of variation in transcription factor binding in yeastQ38345613
DNA-bound transcription factor complexes analysed by mass-spectrometry: binding of novel proteins to the human c-fos SRE and related sequencesQ38659509
Stepwise modification of a modular enhancer underlies adaptation in a Drosophila populationQ38873256
Coupling of enhancer and insulator properties identified in two retrotransposons modulates their mutagenic impact on nearby genesQ39681351
Multiple Functional Variants in cis Modulate PDYN ExpressionQ39775530
YEASTRACT: providing a programmatic access to curated transcriptional regulatory associations in Saccharomyces cerevisiae through a web services interfaceQ41582682
Tissue-specific transcriptional regulation has diverged significantly between human and mouseQ41833705
optix drives the repeated convergent evolution of butterfly wing pattern mimicry.Q42016471
A single p450 allele associated with insecticide resistance in Drosophila.Q44156259
A yeast hybrid provides insight into the evolution of gene expression regulation.Q46029723
Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolutionQ47072530
P433issue1
P921main subjectcis-regulatory elementQ1093165
P304page(s)59-69
P577publication date2011-12-06
P1433published inNature Reviews GeneticsQ1071824
P1476titleCis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence
P478volume13

Reverse relations

cites work (P2860)
Q4594451950/50 Expressional Odds of Retention Signifies the Distinction between Retained Introns and Constitutively Spliced Introns in Arabidopsis thaliana.
Q41503901A Genome-Wide Identification of the WRKY Family Genes and a Survey of Potential WRKY Target Genes in Dendrobium officinale
Q36182021A Mutational Hotspot and Strong Selection Contribute to the Order of Mutations Selected for during Escherichia coli Adaptation to the Gut
Q61807178A Phylogenetic Study of the ANT Family Points to a preANT Gene as the Ancestor of Basal and euANT Transcription Factors in Land Plants
Q35679694A Simple Predictive Enhancer Syntax for Hindbrain Patterning Is Conserved in Vertebrate Genomes
Q51732945A conserved Shh cis-regulatory module highlights a common developmental origin of unpaired and paired fins.
Q27304893A de novo silencer causes elimination of MITF-M expression and profound hearing loss in pigs.
Q35539837A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes
Q27300250A nonsynonymous mutation in the transcriptional regulator lbh is associated with cichlid craniofacial adaptation and neural crest cell development
Q36591253A single generation of domestication heritably alters the expression of hundreds of genes
Q34375251Abundance, arrangement, and function of sequence motifs in the chicken promoters
Q92982828Adaptation to climate change through genetic accommodation and assimilation of plastic phenotypes
Q46093243Adaptive Mutations in RNA Polymerase and the Transcriptional Terminator Rho Have Similar Effects on Escherichia coli Gene Expression.
Q58084814Allele-specific expression elucidates cis-regulatory logic
Q48060778An Essential Regulatory System Originating from Polygenic Transcriptional Rewiring of PhoP-PhoQ of Xanthomonas campestris
Q52690408An Updated Functional Annotation of Protein-Coding Genes in the Cucumber Genome.
Q97643637An osmolality/salinity-responsive enhancer 1 (OSRE1) in intron 1 promotes salinity induction of tilapia glutamine synthetase
Q37671981Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change
Q36743349Anticipatory gene regulation driven by maternal effects in an insect-host system
Q64980625Are Market GM Plants an Unrecognized Platform for Bioterrorism and Biocrime?
Q48161120Asymmetric subgenome selection and cis-regulatory divergence during cotton domestication
Q89855410Bacterial contribution to genesis of the novel germ line determinant oskar
Q58612157Behavior-dependent regulation reveals genes and pathways associated with bower building in cichlid fishes
Q36098175Bioinformatic prediction of transcription factor binding sites at promoter regions of genes for photoperiod and vernalization responses in model and temperate cereal plants
Q59812980Borders of -Regulatory DNA Sequences Preferentially Harbor the Divergent Transcription Factor Binding Motifs in the Human Genome
Q26827700Breaking bad: The mutagenic effect of DNA repair
Q37076768Buffering of Genetic Regulatory Networks in Drosophila melanogaster.
Q47875425Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice
Q64084268Centromere Repeats: Hidden Gems of the Genome
Q28657994Changes in Cis-regulatory Elements during Morphological Evolution
Q35742138Changing Faces of Transcriptional Regulation Reflected by Zic3
Q39780467Characterization of a Citrus R2R3-MYB Transcription Factor that Regulates the Flavonol and Hydroxycinnamic Acid Biosynthesis
Q91643449Characterization of gene promoters in pig: conservative elements, regulatory motifs and evolutionary trend
Q90189630Chromosomal Distribution of Genes Conferring Tolerance to Abiotic Stresses Versus That of Genes Controlling Resistance to Biotic Stresses in Plants
Q89591531Cis and trans-regulatory variation in the domestication of the chili pepper fruit
Q88250867Cis-regulated additively expressed genes play a fundamental role in the formation of triploid loquat (Eriobotrya japonica (Thunb.) Lindl.) Heterosis
Q38700594Cis-regulatory evolution in a wild primate: Infection-associated genetic variation drives differential expression of MHC-DQA1 in vitro.
Q41073596Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids
Q34637378Cis-regulatory sequence variation and association with Mycoplasma load in natural populations of the house finch (Carpodacus mexicanus).
Q37687028Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies
Q49558433Comparative Genomics Reveals Accelerated Evolution in Conserved Pathways during the Diversification of Anole Lizards.
Q38604590Comparative Genomics: One for all.
Q34028280Comparative analyses between retained introns and constitutively spliced introns in Arabidopsis thaliana using random forest and support vector machine
Q34429984Comparative analysis of FLC homologues in Brassicaceae provides insight into their role in the evolution of oilseed rape.
Q36083006Comparative genomics of Steinernema reveals deeply conserved gene regulatory networks
Q41811808Comparative motif discovery combined with comparative transcriptomics yields accurate targetome and enhancer predictions
Q37348950Compartmentalized gene regulatory network of the pathogenic fungus Fusarium graminearum
Q47177941Complex relationships between chromatin accessibility, sequence divergence, and gene expression in A. thaliana
Q55207936Complexity and conservation of regulatory landscapes underlie evolutionary resilience of mammalian gene expression.
Q36363491Comprehensive Expression Profiling of Rice Tetraspanin Genes Reveals Diverse Roles During Development and Abiotic Stress
Q44174342Computational deciphering of biotic stress associated genes in tomato (Solanum lycopersicum).
Q49710778Core cis-element variation confers subgenome-biased expression of a transcription factor that functions in cotton fiber elongation.
Q37728931Cultivar-specific gene modulation in Vitis vinifera: analysis of the promoters regulating the expression of WOX transcription factors.
Q34695037De novo prediction of cis-regulatory elements and modules through integrative analysis of a large number of ChIP datasets
Q28085720Decoding enhancers using massively parallel reporter assays
Q103825979Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure
Q100560124Dense and pleiotropic regulatory information in a developmental enhancer
Q56983868Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method
Q59409977Developmental Bias and Evolution: A Regulatory Network Perspective
Q38312739Direct activation of a mouse Hoxd11 axial expression enhancer by Gdf11/Smad signalling
Q38185270Disruption of long-range gene regulation in human genetic disease: a kaleidoscope of general principles, diverse mechanisms and unique phenotypic consequences
Q37310023Dissecting the Effect of Genetic Variation on the Hepatic Expression of Drug Disposition Genes across the Collaborative Cross Mouse Strains
Q35166735Divergent mechanisms regulate conserved cardiopharyngeal development and gene expression in distantly related ascidians
Q42367974Dominance and Sexual Dimorphism Pervade the Salix purpurea L. Transcriptome
Q35948775Drought responsive gene expression regulatory divergence between upland and lowland ecotypes of a perennial C4 grass.
Q35837630Elucidation of Molecular Identity of the W3 Locus and Its Implication in Determination of Flower Colors in Soybean
Q83227886Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms
Q38997020Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations
Q28084490Emerging applications of read profiles towards the functional annotation of the genome
Q35839674Enhancer Runaway and the Evolution of Diploid Gene Expression
Q34505002Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages
Q22121999Enhancers: five essential questions
Q49886255Environmental and genetic determinants of transcriptional plasticity in Chinook salmon.
Q57024458Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus
Q40064881Epigenomic annotation of gene regulatory alterations during evolution of the primate brain.
Q38561893Epistatic Interactions in the Arabinose Cis-Regulatory Element
Q31167640Establishment of transgenic lines for jumpstarter method using a composite transposon vector in the ladybird beetle, Harmonia axyridis
Q90627378Evaluating Chromatin Accessibility Differences Across Multiple Primate Species Using a Joint Modeling Approach
Q39013266Ever-Changing Landscapes: Transcriptional Enhancers in Development and Evolution
Q41994568Evolution at two levels of gene expression in yeast
Q64117627Evolution of Cold Acclimation and Its Role in Niche Transition in the Temperate Grass Subfamily Pooideae
Q64078017Evolution of Deeper Rooting 1-like homoeologs in wheat entails the C-terminus mutations as well as gain and loss of auxin response elements
Q37630508Evolution of Shh endoderm enhancers during morphological transition from ventral lungs to dorsal gas bladder.
Q46774328Evolution of gene network activity by tuning the strength of negative-feedback regulation
Q40270467Evolution of gene regulation during transcription and translation
Q41309636Evolution of new regulatory functions on biophysically realistic fitness landscapes.
Q35558858Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay
Q33732357Evolution of reduced co-activator dependence led to target expansion of a starvation response pathway
Q35083079Evolution of transcription factor function as a mechanism for changing metazoan developmental gene regulatory networks
Q42909090Evolution of transcriptional enhancers and animal diversity.
Q36904228Evolutionary Dynamics of Floral Homeotic Transcription Factor Protein-Protein Interactions
Q35895359Evolutionary Novelty in a Butterfly Wing Pattern through Enhancer Shuffling
Q90707634Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk
Q33688419Evolutionary changes in transcription factor coding sequence quantitatively alter sensory organ development and function
Q37683468Evolutionary conservation of the eumetazoan gene regulatory landscape
Q38396121Evolutionary dynamics of metazoan TRP channels
Q91370291Evolutionary potential of transcription factors for gene regulatory rewiring
Q92353016Expansion of a core regulon by transposable elements promotes Arabidopsis chemical diversity and pathogen defense
Q36142353Experimental Evolution of Gene Expression and Plasticity in Alternative Selective Regimes
Q38809933Exploiting budding yeast natural variation for industrial processes
Q64239810Expression Changes of Structural Protein Genes May Be Related to Adaptive Skin Characteristics Specific to Humans
Q46243138Expression of a carotenoid-modifying gene and evolution of red colouration in weaverbirds (Ploceidae).
Q39191485Expression quantitative trait locus mapping across water availability environments reveals contrasting associations with genomic features in Arabidopsis.
Q46796946Expression variation of the porcine ADRB2 has a complex genetic background
Q46298716Fitness Effects of Cis-Regulatory Variants in the Saccharomyces cerevisiae TDH3 Promoter
Q28651646From dinosaurs to birds: a tail of evolution
Q27002416From trans to cis: transcriptional regulatory networks in neocortical development
Q48260115Functional characterization of adaptive variation within a cis-regulatory element influencing Drosophila melanogaster growth.
Q90472702Functional characterization of enhancer evolution in the primate lineage
Q46258427Functional divergence of paralogous transcription factors supported the evolution of biomineralization in echinoderms.
Q94469551Functional genomics of parental care of insects
Q48227104Gains and Losses of Cis-regulatory Elements Led to Divergence of the Arabidopsis APETALA1 and CAULIFLOWER Duplicate Genes in the Time, Space, and Level of Expression and Regulation of One Paralog by the Other.
Q36212639Gene Regulation and Speciation
Q50653746Genes, development, and evolvability in primate evolution.
Q92951697Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease
Q33790443Genetic architecture of retinal and macular degenerative diseases: the promise and challenges of next-generation sequencing
Q30992984Genetic assimilation: a review of its potential proximate causes and evolutionary consequences
Q41503984Genetic basis of mycotoxin susceptibility differences between budding yeast isolates.
Q41881206Genetic evidence for conserved non-coding element function across species-the ears have it.
Q89960160Genetic fingerprint defines hematopoietic stem cell pool size and function
Q34549855Genetic variation and expression diversity between grain and sweet sorghum lines.
Q33737782Genome annotation for clinical genomic diagnostics: strengths and weaknesses
Q47133091Genome variation and conserved regulation identify genomic regions responsible for strain specific phenotypes in rat.
Q64087600Genome-Wide Analysis of Family Genes in Foxtail Millet ( L.) and Characterization of the Role of in Drought Tolerance
Q37277395Genome-Wide Gene/Genome Dosage Imbalance Regulates Gene Expressions in Synthetic Brassica napus and Derivatives (AC, AAC, CCA, CCAA).
Q91824250Genome-Wide Genotype-Expression Relationships Reveal Both Copy Number and Single Nucleotide Differentiation Contribute to Differential Gene Expression between Stickleback Ecotypes
Q64092969Genome-Wide Identification, Comprehensive Gene Feature, Evolution, and Expression Analysis of Plant Metal Tolerance Proteins in Tobacco Under Heavy Metal Toxicity
Q93211939Genome-Wide Regulatory Adaptation Shapes Population-Level Genomic Landscapes in Heliconius
Q91736431Genome-wide identification of the amino acid permease genes and molecular characterization of their transcriptional responses to various nutrient stresses in allotetraploid rapeseed
Q92480098Genome-wide identification, structure characterization, and expression pattern profiling of aquaporin gene family in cucumber
Q37366954Genome-wide methylation analysis identified sexually dimorphic methylated regions in hybrid tilapia
Q33591168Genome-wide transcriptome analysis reveals that cadmium stress signaling controls the expression of genes in drought stress signal pathways in rice
Q37626198Genomic analysis reveals major determinants of cis-regulatory variation in Capsella grandiflora.
Q92330394Genomic identification and characterization of MYC family genes in wheat (Triticum aestivum L.).
Q34493603Genomic variation and its impact on gene expression in Drosophila melanogaster
Q90218894GhWRKY70D13 Regulates Resistance to Verticillium dahliae in Cotton Through the Ethylene and Jasmonic Acid Signaling Pathways
Q35877335Global expression differences and tissue specific expression differences in rice evolution result in two contrasting types of differentially expressed genes
Q37430025Heterogeneous tempo and mode of conserved noncoding sequence evolution among four mammalian orders
Q85492685Heterologous expression and comparative characterization of vacuolar invertases from Cu-tolerant and non-tolerant populations of Elsholtzia haichowensis
Q89820747Hierarchical and Dynamic Regulation of Defense-Responsive Specialized Metabolism by WRKY and MYB Transcription Factors
Q41006654High-Throughput Identification of Cis-Regulatory Rewiring Events in Yeast.
Q53284083High-throughput evaluation of T7 promoter variants using biased randomization and DNA barcoding.
Q89999329Homeologs of Brassica SOC1, a central regulator of flowering time, are differentially regulated due to partitioning of evolutionarily conserved transcription factor binding sites in promoters
Q92711559Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
Q42961886Human expression QTLs are enriched in signals of environmental adaptation
Q34471588Hybrid incompatibility arises in a sequence-based bioenergetic model of transcription factor binding
Q35818495Hybrid male sterility and genome-wide misexpression of male reproductive proteases
Q34395064Hybrid mice reveal parent-of-origin and Cis- and trans-regulatory effects in the retina
Q91858157Identification and Conservation Analysis of Cis-Regulatory Elements in Pig Liver
Q35538633Identification and computational analysis of gene regulatory elements.
Q40972113Identification of Lineage-Specific Cis-Regulatory Modules Associated with Variation in Transcription Factor Binding and Chromatin Activity Using Ornstein-Uhlenbeck Models
Q85391282Identification of cis-elements and evaluation of upstream regulatory region of a rice anther-specific gene, OSIPP3, conferring pollen-specific expression in Oryza sativa (L.) ssp. indica
Q35653085Identification of epigenetic modifications that contribute to pathogenesis in therapy-related AML: Effective integration of genome-wide histone modification with transcriptional profiles.
Q35763540Implications of ethylene biosynthesis and signaling in soybean drought stress tolerance.
Q41071735In-silico analysis of cis-acting regulatory elements of pathogenesis-related proteins of Arabidopsis thaliana and Oryza sativa
Q30908787Incorporating chromatin accessibility data into sequence-to-expression modeling
Q34627520Inducing extra copies of the Hsp70 gene in Drosophila melanogaster increases energetic demand
Q90333330Inferring the Molecular Mechanisms of Noncoding Alzheimer's Disease-Associated Genetic Variants
Q99555113Inside the supergene of the bird with four sexes
Q30244869Insights in human epigenomic dynamics through comparative primate analysis
Q39081742Insights into nuclear dynamics using live-cell imaging approaches
Q35080473Intra-specific regulatory variation in Drosophila pseudoobscura
Q56534801Introgression of regulatory alleles and a missense coding mutation drive plumage pattern diversity in the rock pigeon
Q42637764Kinetochore inactivation by expression of a repressive mRNA.
Q58092125Lessons from natural variations: artificially induced heading date variations for improvement of regional adaptation in rice
Q90134371Lineage specific conservation of cis-regulatory elements in Cytokinin Response Factors
Q28596126Lineage-specific genomics: Frequent birth and death in the human genome: The human genome contains many lineage-specific elements created by both sequence and functional turnover
Q27327239Long-range regulatory polymorphisms affecting a GABA receptor constitute a quantitative trait locus (QTL) for social behavior in Caenorhabditis elegans
Q41971425Low-affinity transcription factor binding sites shape morphogen responses and enhancer evolution
Q91124783MIPS: Functional dynamics in evolutionary pathways of plant kingdom
Q90613508Map-Based Functional Analysis of the GhNLP Genes Reveals Their Roles in Enhancing Tolerance to N-Deficiency in Cotton
Q35633163Metagenome Skimming of Insect Specimen Pools: Potential for Comparative Genomics
Q34212558Missing heritability of common diseases and treatments outside the protein-coding exome
Q34201875Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networks
Q103836777Molecular and evolutionary processes generating variation in gene expression
Q92463016Molecular evolution across developmental time reveals rapid divergence in early embryogenesis
Q33784387Molecular hyperdiversity and evolution in very large populations
Q35581305Morphological mutations: lessons from the cockscomb
Q26775592Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation
Q34586044Multi-species comparative analysis of the equine ACE gene identifies a highly conserved potential transcription factor binding site in intron 16.
Q64265730Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy
Q30825424Natural variation in abiotic stress responsive gene expression and local adaptation to climate in Arabidopsis thaliana
Q38582117Natural variation in non-coding regions underlying phenotypic diversity in budding yeast.
Q35765094Neighboring Genes Show Correlated Evolution in Gene Expression
Q36761380Neural Progenitors Adopt Specific Identities by Directly Repressing All Alternative Progenitor Transcriptional Programs
Q37424464Nitric Oxide Responsive Heavy Metal-Associated Gene AtHMAD1 Contributes to Development and Disease Resistance in Arabidopsis thaliana.
Q39110191No Excess of Cis-Regulatory Variation Associated with Intraspecific Selection in Wild Pearl Millet (Cenchrus americanus).
Q53422584Of Men and Mice: Modeling the Fragile X Syndrome.
Q36821389Of mice and men: fuzzy tandem repeats and divergent p53 transcriptional repertoires
Q46207988One-two punch mechanism of gene repression: a fresh perspective on gene regulation.
Q44472745Organ evolution in angiosperms driven by correlated divergences of gene sequences and expression patterns.
Q38994229Orthologous endogenous retroviruses exhibit directional selection since the chimp-human split
Q38622945Overexpressed somatic alleles are enriched in functional elements in Breast Cancer
Q35581720Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans
Q28831431Parallelism and Epistasis in Skeletal Evolution Identified through Use of Phylogenomic Mapping Strategies
Q90482456Perspectives of CRISPR/Cas-mediated cis-engineering in horticulture: unlocking the neglected potential for crop improvement
Q58568474Phenotype loss is associated with widespread divergence of the gene regulatory landscape in evolution
Q87692116Phenotypic novelty by CRISPR in plants
Q90353797Phylogenetic modeling of regulatory element turnover based on epigenomic data
Q111629738Plant adaptation to climate change—Where are we?
Q64070166Plant breeding at the speed of light: the power of CRISPR/Cas to generate directed genetic diversity at multiple sites
Q41613292Pleiotropy constrains the evolution of protein but not regulatory sequences in a transcription regulatory network influencing complex social behaviors.
Q47669345Pod shattering resistance associated with domestication is mediated by a NAC gene in soybean
Q37348052Potential Direct Regulators of the Drosophila yellow Gene Identified by Yeast One-Hybrid and RNAi Screens
Q41289555Potential impact of gene regulatory mechanisms on the evolution of multicellularity in the volvocine algae
Q55214949Prediction and identification of transcriptional regulatory elements at the lung cancer-specific DKK1 locus.
Q39341205Prediction and validation of cis-regulatory elements in 5' upstream regulatory regions of lectin receptor-like kinase gene family in rice
Q47210541Principles and methods of in-silico prioritization of non-coding regulatory variants
Q42334610Progressive Loss of Function in a Limb Enhancer during Snake Evolution
Q54956886Q&A: How do gene regulatory networks control environmental responses in plants?
Q34423553Quantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution
Q28649544Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita
Q31112747Reannotation of Yersinia pestis Strain 91001 Based on Omics Data
Q90244482Recent insights into the genotype-phenotype relationship from massively parallel genetic assays
Q92176963Redundant and Cryptic Enhancer Activities of the Drosophila yellow Gene
Q33739209Regulation of mRNA expression in breast cancer - a cis-tematic trans-action
Q89880986Regulators of an ancient polyphenism evolved through episodic protein divergence and parallel gene radiations
Q88617826Regulatory Divergence in Wound-Responsive Gene Expression between Domesticated and Wild Tomato
Q58789926Regulatory Divergence in the Stress Response of Tomato
Q90741356Regulatory changes in TaSNAC8-6A are associated with drought tolerance in wheat seedlings
Q111629650Regulatory pathways of CYC ‐like genes in patterning floral zygomorphy exemplified in Chirita pumila
Q34420649Repair of naturally occurring mismatches can induce mutations in flanking DNA.
Q38100946Research progress in allele-specific expression and its regulatory mechanisms
Q35096190Retroviruses facilitate the rapid evolution of the mammalian placenta.
Q34509633Role of non-coding sequence variants in cancer
Q38367031Role of transcriptional regulation in the evolution of plant phenotype: A dynamic systems approach
Q42374953SHH signaling directed by two oral epithelium-specific enhancers controls tooth and oral development.
Q96640898SIX1 cooperates with RUNX1 and SMAD4 in cell fate commitment of Müllerian duct epithelium
Q27325642Sequencing of Pax6 loci from the elephant shark reveals a family of Pax6 genes in vertebrate genomes, forged by ancient duplications and divergences
Q58084808Spatially varying cis-regulatory divergence in Drosophila embryos elucidates cis-regulatory logic
Q99236135Speciation and the developmental alarm clock
Q40258257Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate
Q99712241Spotlight on the Granules (Grainyhead-Like Proteins) - From an Evolutionary Conserved Controller of Epithelial Trait to Pioneering the Chromatin Landscape
Q28068326Stress-Mediated cis-Element Transcription Factor Interactions Interconnecting Primary and Specialized Metabolism in planta
Q54979583Structural, Functional, and Evolutionary Characterization of Major Drought Transcription Factors Families in Maize.
Q36744733Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia
Q38883822Structure of the Transcriptional Regulatory Network Correlates with Regulatory Divergence in Drosophila
Q40311561Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs
Q39198293Systematic Discovery of Chromatin-Bound Protein Complexes from ChIP-seq Datasets
Q54310538Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types.
Q55439616Systematic pan-cancer analysis of somatic allele frequency.
Q64074428Systems Biology of Cold Adaptation in the Polyextremophilic Red Alga
Q64985798TFforge utilizes large-scale binding site divergence to identify transcriptional regulators involved in phenotypic differences.
Q90640189Testing Proximity of Genomic Regions to Transcription Start Sites and Enhancers Complements Gene Set Enrichment Testing
Q58571319The Ciona Myogenic Regulatory Factor Functions as a Typical MRF but Possesses a Novel N-terminus that is Essential for Activity
Q35151849The CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element (PRE).
Q92202735The Role of Chromatin Accessibility in cis-Regulatory Evolution
Q116202018The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype
Q33839420The chromatin landscape of Drosophila: comparisons between species, sexes, and chromosomes
Q37202233The evolution of lineage-specific regulatory activities in the human embryonic limb
Q28727265The evolution of root hairs and rhizoids
Q43243104The frequent evolutionary birth and death of functional promoters in mouse and human
Q28542978The genetic and mechanistic basis for variation in gene regulation
Q91168851The genetic architecture of adaptation: convergence and pleiotropy in Heliconius wing pattern evolution
Q37628813The nature and extent of mutational pleiotropy in gene expression of male Drosophila serrata.
Q34973346The nitrate transporter (NRT) gene family in poplar
Q56139379The placenta as a model for understanding the origin and evolution of vertebrate organs
Q35400045The role of cis regulatory evolution in maize domestication.
Q90024199Tissue-Specific cis-Regulatory Divergence Implicates eloF in Inhibiting Interspecies Mating in Drosophila
Q55323106Towards a map of cis-regulatory sequences in the human genome.
Q91982895Towards the new normal: Transcriptomic convergence and genomic legacy of the two subgenomes of an allopolyploid weed (Capsella bursa-pastoris)
Q90230262Transcription Factors AhR/ARNT Regulate the Expression of CYP6CY3 and CYP6CY4 Switch Conferring Nicotine Adaptation
Q35894089Transcription Factors Exhibit Differential Conservation in Bacteria with Reduced Genomes
Q42345745Transcriptional Interference Promotes Rapid Expression Divergence of Drosophila Nested Genes
Q52630978Transcriptional and epigenetic adaptation of maize chromosomes in Oat-Maize addition lines.
Q34631682Transcriptional and epigenetic regulation of T-helper lineage specification
Q38695449Transcriptional regulation of early T-cell development in the thymus
Q85714318Transcriptional regulation of tocopherol biosynthesis in tomato
Q28959138Transcriptome profiling and comparison of maize ear heterosis during the spikelet and floret differentiation stages
Q47799938Transposable Element Mediated Innovation in Gene Regulatory Landscapes of Cells: Re-Visiting the "Gene-Battery" Model
Q48314118Two genetic changes in cis-regulatory elements caused evolution of petal spot position in Clarkia.
Q91802270Understanding the Role of the WRKY Gene Family under Stress Conditions in Pigeonpea (Cajanus Cajan L.).
Q91496533Unraveling cis and trans regulatory evolution during cotton domestication
Q37009014Variation in the Oxytocin Receptor Gene Predicts Brain Region-Specific Expression and Social Attachment
Q39043824Waiting in the wings: what can we learn about gene co-option from the diversification of butterfly wing patterns?
Q27301792Weak Polygenic Selection Drives the Rapid Adaptation of the Chemosensory System: Lessons from the Upstream Regions of the Major Gene Families
Q64058206Weighting sequence variants based on their annotation increases the power of genome-wide association studies in dairy cattle
Q116816834Whole Genome Sequencing Reveals the Structure of Environment-Associated Divergence in a Broadly Distributed Montane Bumble Bee, Bombus vancouverensis
Q38236999Whole-genome duplication in teleost fishes and its evolutionary consequences

Search more.