Scientific Opinion on acrylamide in food

scientific article published in June 2015

Scientific Opinion on acrylamide in food is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2903/J.EFSA.2015.4104

P50authorEFSA Panel On Contaminants In The Food ChainQ62579451
P2860cites workDietary acrylamide intake and the risk of colorectal cancer with specific mutations in KRAS and APC.Q53243955
Dietary acrylamide does not increase colon aberrant crypt foci formation in male F344 rats.Q53260262
Protective effect of allicin against acrylamide-induced hepatocyte damage in vitro and in vivo.Q53269096
An absorption study of dietary administered acrylamide in swine.Q53336700
Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide.Q53341553
Urinary metabolites from F344 rats and B6C3F1 mice coadministered acrylamide and acrylonitrile for 1 or 5 days.Q53437625
A Lifetime Oncogenicity Study in Rats with AcrylamideQ53462377
Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide.Q53463937
Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites.Q53495583
Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adduct formation.Q53505582
Acrylamide effects on kinesin-related proteins of the mitotic/meiotic spindle.Q53549464
Metabolism of acrylamide to glycidamide and their cytotoxicity in isolated rat hepatocytes: protective effects of GSH precursors.Q53622919
Acrylamide monomer and peripheral neuropathy in chemical workersQ53851600
Distribution and binding of [14C]acrylamide to macromolecules in SENCAR and BALB/c mice following oral and topical administration.Q53864395
The effects of acrylamide on beta-glucuronidase and acid phosphatase activities in rat sciatic nerve above and below a ligature.Q53878922
Breathing pattern, lung inflation reflex and airway tone in acrylamide neuropathy.Q54353985
Histological changes of acrylamide-induced testicular lesions in mice.Q54382268
Dehydrated Foods, Chemistry of Browning Reactions in Model SystemsQ55896006
Acrylamide: A Cooking Carcinogen?Q56115376
Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohortQ57026302
Chronic exposure to acrylamide induces DNA damage in male germ cells of miceQ57213172
Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical regionQ57271316
Relationships between Biomarkers of Exposure and Neurological Effects in a Group of Workers Exposed to AcrylamideQ57555008
Dietary acrylamide and renal cell cancerQ57559783
Dietary acrylamide intake and risk of esophageal cancer in a population-based case-control study in SwedenQ58204536
Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathwayQ59117849
Acrylamide in espresso coffee: Influence of species, roast degree and brew lengthQ59276291
Challenges in estimating the validity of dietary acrylamide measurementsQ43441117
Rat two-generation reproduction and dominant lethal study of acrylamide in drinking waterQ43507958
Development of new indole-derived neuroprotective agentsQ43577923
Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosingQ43676843
Dietary acrylamide intake and prostate cancer risk in a prospective cohort of Swedish men.Q43714654
Tissue-specific genotoxic effects of acrylamide and acrylonitrileQ43716360
Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methylolacrylamide treatmentQ43954340
Long-term dietary acrylamide intake and breast cancer risk in a prospective cohort of Swedish womenQ43965420
Investigations into acrylamide precursors in sterilized table olives: evidence of a peptic fraction being responsible for acrylamide formationQ43982289
Dietary acrylamide intake is not associated with gastrointestinal cancer riskQ43998303
Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adultsQ44033822
Effects of long term low dose acrylamide exposure on rat bone marrow polychromatic erythrocytesQ44173092
Maternal acrylamide treatment reduces ovarian follicle number in newborn guinea pig offspringQ44232076
Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamideQ44290756
Comparison of the hemoglobin adducts formed by administration of N-methylolacrylamide and acrylamide to rats.Q44300339
The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assayQ44311932
A first approach to estimate the internal exposure to acrylamide in smoking and non-smoking adults from GermanyQ44351791
Acrylamide: increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans.Q44388982
Dietary acrylamide exposure of the French population: results of the second French Total Diet StudyQ44398949
Biological monitoring for occupational acrylamide exposure from acrylamide production workers.Q44446052
Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR.Q44457201
Acrylamide neuropathy in a South African factory: An epidemiologic investigationQ44470020
Weak yet distinct mutagenicity of acrylamide in mammalian cellsQ44482255
Effective suppression of acrylamide neurotoxicity by lithium in mouseQ44490438
Reevaluation of the induction of specific-locus mutations in spermatogonia of the mouse by acrylamideQ44495275
Possible neoplastic effects of acrylamide on rat exocrine pancreas.Q44527360
A sensitive gas chromatographic-tandem mass spectrometric method for detection of alkylating agents in water: application to acrylamide in drinking water, coffee and snuffQ44578707
DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice.Q44622736
The influence of deep frying using various vegetable oils on acrylamide formation in sweet potato (Ipomoea batatas L. Lam) chips.Q44623640
Investigations of Factors That Influence the Acrylamide Content of Heated FoodstuffsQ44651178
Potential protective effects of oral administration of allicin on acrylamide-induced toxicity in male miceQ44657008
Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamideQ44670357
Progressive deficits in retrograde axon transport precede degeneration of motor axons in acrylamide neuropathyQ44680684
Eco-friendly ionic liquid based ultrasonic assisted selective extraction coupled with a simple liquid chromatography for the reliable determination of acrylamide in food samplesQ44690087
Acrylamide formation mechanism in heated foodsQ44713831
Trans-placental exposure of neonates to acrylamide--a pilot studyQ44739878
Dietary acrylamide and risk of renal cell cancerQ44785985
In vivo and in vitro effects of acrylamide on synaptosomal neurotransmitter uptake and releaseQ44798737
Reliability of retrospective information on diet 20 years ago and consistency of independent measurements of remote adolescent dietQ44817024
Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC-ES/MS/MS.Q44819349
Effects of asparagine, fructose, and baking conditions on acrylamide content in yeast-leavened wheat breadQ44821502
The immunosuppressant FK506 elicits a neuronal heat shock response and protects against acrylamide neuropathyQ44842425
Processing treatments for mitigating acrylamide formation in sweetpotato French friesQ44871528
Investigation of the low-dose response in the in vivo induction of micronuclei and adducts by acrylamideQ44882154
Comparison of acrylamide intake from Western and guideline based diets using probabilistic techniques and linear programmingQ44891534
Reduction of acrylamide uptake by dietary proteins in a caco-2 gut modelQ44928304
A neurotoxicity screening battery for use in safety evaluation: Effects of acrylamide and 3?,3?-iminodipropionitrileQ44937764
Cytotoxicity and chromosomal aberrations induced by acrylamide in V79 cells: role of glutathione modulatorsQ44964001
Genotoxicity of acrylamide and glycidamide.Q44968987
Quantitation of 3-aminopropionamide in potatoes-a minor but potent precursor in acrylamide formationQ44986455
Critical review of dose-response options for F344 rat mammary tumors for acrylamide - additional insights based on mode of actionQ37988234
Review of epidemiologic studies of dietary acrylamide intake and the risk of cancerQ38001888
Glutathione conjugate mediated toxicitiesQ38003817
Comparison of PBTK model and biomarker based estimates of the internal dosimetry of acrylamideQ38109418
Current issues in dietary acrylamide: formation, mitigation and risk assessmentQ38128539
Acrylamide: formation, occurrence in food products, detection methods, and legislationQ38171856
Risks of dietary acrylamide exposure: a systematic reviewQ38200268
Acrylamide analysis in food by liquid chromatographic and gas chromatographic methods.Q38267674
Dietary acrylamide and cancer risk: an updated meta-analysisQ38268857
Toxicological effects of acrylamide on rat testicular gene expression profileQ38329738
Heritable translocations induced by dermal exposure of male mice to acrylamideQ38478762
Induction of chromosomal aberrations in mouse zygotes by acrylamide treatment of male germ cells and their correlation with dominant lethality and heritable translocationsQ38505604
Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.Q38512559
Acrylamide Induces Senescence in Macrophages through a Process Involving ATF3, ROS, p38/JNK, and a Telomerase-Independent PathwayQ38926378
Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines.Q39032757
Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidamide in human mammary cellsQ39073303
Fast and simple screening for the simultaneous analysis of seven metabolites derived from five volatile organic compounds in human urine using on-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometryQ39083796
Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells.Q39150202
Dose dependent molecular effects of acrylamide and glycidamide in human cancer cell lines and human primary hepatocytesQ39216754
Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cellsQ39249347
Prophylaxis with Bacopa monnieri attenuates acrylamide induced neurotoxicity and oxidative damage via elevated antioxidant functionQ39254445
Megaoesophagus due to acrylamide neuropathyQ39257230
The effect of acrylamide and nitric oxide donors on human mesenchymal progenitor cells.Q39356886
Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells.Q39385006
Acrylamide up-regulates cyclooxygenase-2 expression through the MEK/ERK signaling pathway in mouse epidermal cellsQ39579405
Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicityQ39625829
Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cellsQ39667048
The inhibitory effect of acrylamide on NCAM expression in human neuroblastoma cells: involvement of CK2/Ikaros signaling pathwayQ39667702
The effect of domestic preparation of some potato products on acrylamide content.Q39723640
Genotoxicity of acrylamide in vitro: Acrylamide is not metabolically activated in standard in vitro systemsQ39731177
Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis.Q39758894
Urinary mercapturic acids and a hemoglobin adduct for the dosimetry of acrylamide exposure in smokers and nonsmokersQ39758958
Acrylamide catalytically inhibits topoisomerase II in V79 cells.Q39763938
Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-oneQ39961879
Human CYP2E1 mediates the formation of glycidamide from acrylamideQ39991110
Carcinogenic and toxicologic effects of inhaled ethylene oxide and propylene oxide in F344 ratsQ23912051
Occupational exposure to acrylamide in closed system production plants: air levels and biomonitoringQ23923720
Listing occupational carcinogens.Q24816074
DNA and protein adducts in human tissues resulting from exposure to tobacco smokeQ27021044
Evaluating the potential for enzymatic acrylamide mitigation in a range of food products using an asparaginase from Aspergillus oryzaeQ28242275
The same chemicals induce different neurotoxicity when administered in high doses for short term or low doses for long term to rats and dogsQ28316541
Acrylamide-regulated neurofilament expression in rat pheochromocytoma cellsQ28370600
Mouse spermatocytes express CYP2E1 and respond to acrylamide exposureQ28538395
Neurobehavioral and transcriptional effects of acrylamide in juvenile ratsQ28574915
Dealing with dietary measurement error in nutritional cohort studiesQ28742148
Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: considerations of biological relevance of tumour type, data quality and uncQ30686945
Dispersive infrared spectroscopy measurements of atmospheric CO₂ using a Fabry-Pérot interferometer sensor.Q30704555
Acrylamide: a comparison of metabolism and hemoglobin adducts in rodents following dermal, intraperitoneal, oral, or inhalation exposure.Q30814380
Comparison of acrylamide metabolism in humans and rodentsQ31030650
European Union database of acrylamide levels in food: update and critical review of data collection.Q31121320
Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effectsQ33257606
Urinary excretion of acrylamide and metabolites in Fischer 344 rats and B6C3F(1) mice administered a single dose of acrylamideQ33269283
Using dietary exposure and physiologically based pharmacokinetic/pharmacodynamic modeling in human risk extrapolations for acrylamide toxicityQ33351455
Alcohol influence on acrylamide to glycidamide metabolism assessed with hemoglobin-adducts and questionnaire dataQ33520759
Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicityQ33573301
Exposure of the U.S. population to acrylamide in the National Health and Nutrition Examination Survey 2003-2004Q33702726
"IARC group 2A Carcinogens" reported in cigarette mainstream smokeQ33866631
Acrylamide exposure measured by food frequency questionnaire and hemoglobin adduct levels and prostate cancer risk in the Cancer of the Prostate in Sweden StudyQ34000423
Role of nitric oxide in the regulation of monoaminergic neurotransmissionQ34023895
Long-lasting inhibition of presynaptic metabolism and neurotransmitter release by protein S-nitrosylationQ34073840
Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohortQ34113479
Acrylamide exposure impairs blood-cerebrospinal fluid barrier functionQ34128070
Glutathione conjugation as a bioactivation reactionQ34129195
Analysis of acrylamide, a carcinogen formed in heated foodstuffsQ34143312
Acrylamide is formed in the Maillard reactionQ34153328
Acrylamide from Maillard reaction productsQ34153333
Mutagenicity of acrylamide and glycidamide in the testes of big blue mice.Q34169556
Meta-analysis of data from human ex vivo placental perfusion studies on genotoxic and immunotoxic agents within the integrated European project NewGenerisQ34177881
Acrylamide in children--exposure assessment via urinary acrylamide metabolites as biomarkersQ46538698
Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue miceQ46547843
Formation of hemoglobin adducts of acrylamide after its ingestion in rats is dependent on age and sex.Q46550493
Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effectQ46570057
Internal doses of acrylamide and glycidamide in mice fed diets with low acrylamide contentsQ46581679
Dietary acrylamide and human cancer.Q46589488
Prospective study of dietary acrylamide and risk of colorectal cancer among womenQ46589509
Acrylamide does not induce tumorigenesis or major defects in mice in vivo.Q46593396
Acrylamide-occurrence in mixed concentrate feed for dairy cows and carry-over into milkQ46600860
The effects of subchronic acrylamide exposure on gene expression, neurochemistry, hormones, and histopathology in the hypothalamus-pituitary-thyroid axis of male Fischer 344 ratsQ46631602
Developmental and behavioral effects of acrylamide in Fischer 344 ratsQ46640314
Determination of the major mercapturic acids of acrylamide and glycidamide in human urine by LC-ESI-MS/MS.Q46660128
Biological effects of acrylamide after daily ingestion of various foods in comparison to water: A study in ratsQ46663347
Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adductsQ46686110
Nerve conduction, visual evoked responses and electroretinography in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agentsQ46692149
Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamideQ46717153
Reproducibility and validity of dietary assessment instruments. I. A self-administered food use questionnaire with a portion size picture bookletQ46723619
Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary studyQ46731462
Acrylamide inhibits dopamine uptake in rat striatal synaptic vesiclesQ46738341
Toxicokinetics of acrylamide and glycidamide in Fischer 344 ratsQ46765703
Pyrolytic acrylamide formation from purified wheat gluten and gluten-supplemented wheat bread rollsQ46827828
The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamideQ46842686
Genotoxicity of acrylamide and glycidamide in human lymphoblastoid TK6 cellsQ46875008
Determination and quantification of urinary metabolites after dietary exposure to acrylamideQ46879956
Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cellsQ46886768
Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells.Q46889144
A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancerQ46897495
The association between self-reported acrylamide intake and hemoglobin adducts as biomarkers of exposureQ46912869
Colour vision and light sensitivity in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agentsQ46940691
Automated method for measuring globin adducts of acrylamide and glycidamide at optimized Edman reaction conditionsQ46945546
Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicityQ46956121
Effect of frying instructions for food handlers on acrylamide concentration in French fries: an explorative studyQ46959793
Management of left‐censored data in dietary exposure assessment of chemical substancesQ47148196
Results on acrylamide levels in food from monitoring year 2008Q47148356
Use of the EFSA Comprehensive European Food Consumption Database in Exposure AssessmentQ47149547
Results on acrylamide levels in food from monitoring years 2007-2009 and Exposure assessmentQ47149845
Report on the development of a Food Classification and Description System for exposure assessment and guidance on its implementation and useQ47151006
Overview of the procedures currently used at EFSA for the assessment of dietary exposure to different chemical substancesQ47151011
Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured dataQ47151301
Scientific Opinion on Risk Assessment TerminologyQ47151607
Update on acrylamide levels in food from monitoring years 2007 to 2010Q47152408
Minimum Criteria for the acceptance ofin vivoalkaline Comet Assay ReportsQ47152644
Potato fiber protects the small intestinal wall against the toxic influence of acrylamide.Q47217833
The impact on infant birth weight and gestational age of cotinine-validated smoking reduction during pregnancyQ47396254
Reproductive toxicity associated with acrylamide treatment in male and female ratsQ47599762
Biochemical and morphologic characterization of acrylamide peripheral neuropathyQ47674340
Determination of acrylamide level in commercial baby foods and an assessment of infant dietary exposureQ47728259
Global gene expression analysis in cord blood reveals gender-specific differences in response to carcinogenic exposure in uteroQ47774300
Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from DenmarkQ47787249
In vivo binding of [(14)C]acrylamide to proteins in the mouse nervous systemQ47795485
Comparative tissue distribution and excretion of [1-14C]acrylamide in beagle dogs and miniature pigsQ48185142
Changes in thyroid gland morphology after acute acrylamide exposureQ48224332
Neurotoxicity of acrylamide in developing rat brain: changes in the levels of brain biogenic amines and activities of monoamine oxidase and acetylcholine esteraseQ48231210
The effect of acrylamide on alpha-naphthyl acetate esterase enzyme in blood circulating lymphocytes and gut associated lymphoid tissues in ratsQ48237529
The distribution of [14C]acrylamide in male and pregnant Swiss-Webster mice studied by whole-body autoradiographyQ48269158
Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 ratsQ48299480
Mortality patterns among workers exposed to acrylamide: updated follow up.Q48313525
Self-reported symptoms and neuropsychological function among tunnel workers previously exposed to acrylamide and N-methylolacrylamideQ48343374
Effects of chronic low-dose acrylamide exposure on progressive ratio performance in adolescent ratsQ48387257
Ameliorating effect of fish oil on acrylamide induced oxidative stress and neuronal apoptosis in cerebral cortexQ48488396
Alteration of amino acid incorporation into proteins of the nervous system in vitro after administration of acrylamide to ratsQ48663601
Neurotoxicity of acrylamide and related compounds in rats. Effects on rotarod performance, morphology of nerves and neurotubulinQ48717105
Acrylamide and carbon disulfide treatments increase the rate of rat brain tubulin polymerizationQ48736582
Ultrastructural features of the Purkinje cell damage caused by acrylamide in the rat: a new phenomenon in cellular neuropathologyQ48797529
Effect of acrylamide on neurotransmitter metabolism and neuropeptide levels in several brain regions and upon circulating hormonesQ48852884
Biochemical studies on acrylamide, a neurotoxic agentQ48897561
The pathokinetics of acrylamide intoxication: a reassessment of the problemQ48930374
Selective loss of Purkinje cells from the rat cerebellum caused by acrylamide and the responses of beta-glucuronidase and beta-galactosidaseQ49087799
Uptake, disposition, and elimination of acrylamide in rainbow troutQ49165619
Mutagenicity of cytochrome P450 2E1 substrates in the Ames test with the metabolic competent S. typhimurium strain YG7108pin3ERb5.Q50077058
Salmonella mutagenicity tests: III. Results from the testing of 255 chemicalsQ50201968
Mutagenicity of acrylamide and its analogues in Salmonella typhimuriumQ50204739
The mutagenic action of aliphatic epoxidesQ50216153
Expression analysis of hepatic mitochondria-related genes in mice exposed to acrylamide and glycidamide.Q50249017
Camellia sinensis (green tea) extract attenuate acrylamide induced testicular damage in albino rats.Q50484682
A 13-week toxicity study of acrylamide administered in drinking water to hamsters.Q50500874
Dietary determinants for Hb-acrylamide and Hb-glycidamide adducts in Danish non-smoking women.Q50553080
Pre-diagnostic acrylamide exposure and survival after breast cancer among postmenopausal Danish women.Q50556058
Testicular development of male mice offsprings exposed to acrylamide and alcohol during the gestation and lactation period.Q50648193
Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons.Q50670832
Studies on acrylamide levels in roasting, storage and brewing of coffee.Q50710920
Somatosensory thresholds in monkeys exposed to acrylamide.Q50847588
Mixture genotoxicity of 2,4-dichlorophenoxyacetic acid, acrylamide, and maleic hydrazide on human Caco-2 cells assessed with comet assay.Q50952809
Dietary acrylamide intake and risk of endometrial cancer in prospective cohort studies.Q51068694
Reproductive toxicity in acrylamide-treated female mice.Q51145123
Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a 2-year drinking water exposure.Q51308270
N7-glycidamide-guanine DNA adduct formation by orally ingested acrylamide in rats: a dose-response study encompassing human diet-related exposure levels.Q51370786
Acrylamide exposure via the diet: influence of fasting on urinary mercapturic acid metabolite excretion in humans.Q51496280
Concentrations of free amino acids and sugars in nine potato varieties: effects of storage and relationship with acrylamide formation.Q51535816
Effects of fried potato chip supplementation on mouse pregnancy and fetal development.Q51550811
Mutagenic activity of acrylamide in the rat thyroid cells under conditions of a subacute experiment.Q51556124
The effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity of rat bone marrow cells.Q51583636
Dietary acrylamide and pancreatic cancer risk in an Italian case--control study.Q51607510
Physiologically based pharmacokinetic/pharmacodynamic model for acrylamide and its metabolites in mice, rats, and humans.Q51764790
³²P-HPLC analysis of N1-(2-carboxy-2-hydroxyethyl)deoxyadenosine: a DNA adduct of the acrylamide-derived epoxide glycidamide.Q51765616
Measured consumption of commercial infant food products in German infants: results from the DONALD study. Dortmund Nutritional and Anthropometrical Longitudinally Designed.Q52182206
Developmental toxicity evaluation of acrylamide in rats and mice.Q52241779
Acrylamide arrests mitosis and prevents chromosome migration in the absence of changes in spindle microtubules.Q52510986
Acrylamide exposure among Turkish toddlers from selected cereal-based baby food samples.Q53105081
Two-year carcinogenicity study of acrylamide in Wistar Han rats with in utero exposure.Q53225552
Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effectQ45050350
Dietary intake of acrylamide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohortQ45120032
Telomerase activity-independent function of telomerase reverse transcriptase is involved in acrylamide-induced neuron damageQ45120184
Genotoxicity of acrylamide in human lymphocytesQ45121565
Neuroprotective efficacy of eugenol and isoeugenol in acrylamide-induced neuropathy in rats: behavioral and biochemical evidenceQ45168373
Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 miceQ45175762
Toxicokinetics of acrylamide and glycidamide in B6C3F1 miceQ45236353
DNA damage and DNA adduct formation in rat tissues following oral administration of acrylamideQ45236537
DNA adducts derived from administration of acrylamide and glycidamide to mice and ratsQ45236538
Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general populationQ45236546
Serum homocysteine, arginine, citrulline and asymmetric dimethyl arginine levels, and histopathologic examination of the abdominal aorta in rats exposed to acrylamideQ45241716
Determination of haemoglobin adducts of acrylamide and glycidamide in smoking and non-smoking persons of the general population.Q45281808
A method for the determination of acrylamide in bakery products using ion trap LC-ESI-MS/MS.Q45370972
Induction of sister chromatid exchange by acrylamide and glycidamide in human lymphocytes: role of polymorphisms in detoxification and DNA-repair genes in the genotoxicity of glycidamideQ45374167
Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamideQ45578881
Acrylamide levels in Finnish foodstuffs analysed with liquid chromatography tandem mass spectrometryQ45710446
Increased micronucleus frequency in rat bone marrow after acrylamide treatment.Q45980936
The role of human cytochrome P450 enzymes in metabolism of acrylamide in vitro.Q46018573
Lung cancer risk in relation to dietary acrylamide intake.Q46032893
Dietary acrylamide intake and brain cancer risk.Q46041862
Associations of acrylamide intake with circulating levels of sex hormones and prolactin in premenopausal Japanese womenQ46069484
Limited lactational transfer of acrylamide to rat offspring on maternal oral administration during the gestation and lactation periodsQ46078849
Paternally transmitted chromosomal aberrations in mouse zygotes determine their embryonic fateQ46092951
Pathogenesis of neurotoxicity of acrylates acrylonitrile and acrylamide: from cell to organism.Q46102545
Acrylamide as environmental noxious agent: a health risk assessment for the general population based on the internal acrylamide burdenQ46115652
Long-term dietary acrylamide intake and risk of epithelial ovarian cancer in a prospective cohort of Swedish womenQ46119123
In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humansQ46135147
Effect of acrylamide on some hormones and endocrine tissues in male ratsQ46166884
DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide.Q46175101
Dietary acrylamide intake and risk of colorectal cancer in a prospective cohort of men.Q46176060
Toxicokinetics of acrylamide in rats and humans following single oral administration of low dosesQ46177821
Structural and ultrastructural evidence of neurotoxic effects of fried potato chips on rat postnatal developmentQ46195522
Long-term dietary acrylamide intake and risk of endometrial cancer in a prospective cohort of Swedish womenQ46219711
Monoclonal antibody development for acrylamide-adducted human haemoglobin; a biomarker of dietary acrylamide exposureQ46235970
Proteomic approach for the analysis of acrylamide-hemoglobin adducts. Perspectives for biological monitoringQ46242844
Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometryQ46246160
N-Acetyl-S-(1-carbamoyl-2-hydroxy-ethyl)-L-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: comparison with the simultaneously excreted other mercaptuic acidsQ46299093
Rapid and sensitive HILIC-ESI-MS/MS quantitation of polar metabolites of acrylamide in human urine using column switching with an online trap columnQ46326248
Effects of lactational administration of acrylamide on rat dams and offspringQ46355676
Developmental neurotoxicity evaluation of acrylamide in Sprague-Dawley ratsQ46362785
Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placentaQ46369447
In Vivo Doses of Acrylamide and Glycidamide in Humans after Intake of Acrylamide-Rich FoodQ46369693
Carry over (transfer) of feed-borne acrylamide into eggs, muscle, serum, and faeces - a pilot study with Japanese quails (Coturnix coturnix japonica).Q46401669
Gas chromatographic-mass spectrometric analysis of acrylamide and acetamide in cigarette mainstream smoke after on-column injectionQ46418297
The acrylamide intake via some common baby food for children in Sweden during their first year of life--an improved method for analysis of acrylamideQ46423237
Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acrolein (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography/tandem mass spectrometryQ46455777
Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) StudyQ46485842
Hemoglobin adducts and mercapturic acid excretion of acrylamide and glycidamide in one study populationQ46485860
Acrylamide: a dietary carcinogen formed in vivo?Q46485864
Development of a stable isotope dilution assay for the quantitation of glycidamide and its application to foods and model systemsQ46485873
A Prospective Study on Dietary Acrylamide Intake and the Risk for Breast, Endometrial, and Ovarian CancersQ34185577
Hemoglobin adducts as a measure of variations in exposure to acrylamide in food and comparison to questionnaire dataQ34242448
Wnt signaling in cancerQ34262857
Analysis of coffee for the presence of acrylamide by LC-MS/MS.Q34309760
Dietary acrylamide intake and the risk of lymphatic malignancies: the Netherlands Cohort Study on diet and cancerQ34313797
Acrylamide in gingerbread: critical factors for formation and possible ways for reductionQ34328549
Dietary acrylamide intake and risk of breast cancer in the UK women's cohortQ34363496
Risk assessment, formation, and mitigation of dietary acrylamide: current status and future prospects.Q34414254
Effects of consumer food preparation on acrylamide formation.Q34488436
Chronic intake of potato chips in humans increases the production of reactive oxygen radicals by leukocytes and increases plasma C-reactive protein: a pilot studyQ34603382
A combined carcinogen bioassay utilizing both the lung adenoma and skin papilloma protocolsQ34658880
Acrylamide exposure and incidence of breast cancer among postmenopausal women in the Danish Diet, Cancer and Health StudyQ34734261
Nerve terminals as the primary site of acrylamide action: a hypothesisQ34775151
Fast axonal transport: a site of acrylamide neurotoxicity?Q34841278
Dietary intake of acrylamide and epithelial ovarian cancer risk in the european prospective investigation into cancer and nutrition (EPIC) cohortQ34973549
Negligible colon cancer risk from food-borne acrylamide exposure in male F344 rats and nude (nu/nu) mice-bearing human colon tumor xenograftsQ34989493
Effects of acrylamide on rodent reproductive performanceQ35036643
Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamideQ35138410
Role of the Nrf2-ARE pathway in acrylamide neurotoxicityQ35146399
Simple analytical strategy for MALDI-TOF-MS and nanoUPLC-MS/MS: quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators reduced by curcumin.Q35531903
Mortality patterns among workers exposed to acrylamide: 1994 follow upQ35561146
Analytical methods for the determination of acrylamide in food products: a review.Q35574211
Human carcinogenic risk evaluation: an alternative approach to the two-year rodent bioassayQ35765289
The changing view of acrylamide neurotoxicityQ35795743
Relevance of animal carcinogenesis findings to human cancer predictions and preventionQ35812499
Dietary acrylamide and risk of prostate cancerQ35873768
Metabolism and hemoglobin adduct formation of acrylamide in humans.Q35996367
Acrylamide: an update on current knowledge in analysis, levels in food, mechanisms of formation, and potential strategies of controlQ36008392
The carcinogenicity of acrylamideQ36018964
Transmitted mutational events induced in mouse germ cells following acrylamide or glycidamide exposureQ36018970
NTP-CERHR expert panel report on the reproductive and developmental toxicity of acrylamide.Q36053770
Mortality study update of acrylamide workersQ36145311
Occurrence and analytical methods of acrylamide in heat-treated foods. Review and recent developmentsQ36172148
Ovarian cancer and smoking: individual participant meta-analysis including 28,114 women with ovarian cancer from 51 epidemiological studiesQ36201263
Dietary exposure assessments for children in europe (the EXPOCHI project): rationale, methods and designQ36217652
Dietary acrylamide intake and the risk of cancer among Finnish male smokersQ36395498
Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicalsQ36447484
Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus (MN) and Comet assay protocolQ36462353
Evaluation of acrylamide in food from China by a LC/MS/MS methodQ36473531
Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicantsQ36552795
‘Acrylamide-induced‘ neuropathy and impairment of axonal transport of proteins. II. Abnormal accumulations of smooth endoplasmic reticulum as sites of focal retention of fast transported proteins. Electron microscope radioautographic studyQ36589591
Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in SwedenQ36647809
A review of mechanisms of acrylamide carcinogenicity.Q36711993
Hazardous effects of fried potato chips on the development of retina in albino ratsQ36734222
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassayQ36736730
Acrylamide hemoglobin adduct levels and ovarian cancer risk: a nested case-control studyQ36741622
Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa)Q36752313
Among 10 sociodemographic and lifestyle variables, smoking is strongly associated with biomarkers of acrylamide exposure in a representative sample of the U.S. PopulationQ36771615
The German minimization concept for acrylamideQ36905608
Protein targets of acrylamide adduct formation in cultured rat dopaminergic cellsQ37000219
Protective effect of l-carnitine against acrylamide-induced DNA damage in somatic and germ cells of miceQ37062749
Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genesQ37101545
Acrylamide concentrations in potato crisps in Europe from 2002 to 2011.Q37186388
Inhibition of rat testicular nuclear kinesins (krp2; KIFC5A) by acrylamide as a basis for establishing a genotoxicity thresholdQ37215143
Evidence-based dose-response assessment for thyroid tumorigenesis from acrylamideQ37262557
Dietary acrylamide intake and risk of premenopausal breast cancerQ37306069
Associations between dietary acrylamide intake and plasma sex hormone levelsQ37308209
Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamideQ37327116
Evaluation of human relevance and mode of action for tunica vaginalis mesotheliomas resulting from oral exposure to acrylamideQ37376523
Acrylamide: Consideration of species differences and nonlinear processes in estimating risk and safety for human ingestion.Q37376528
Induction of tunica vaginalis mesotheliomas in rats by xenobioticsQ37526974
Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE: acrylamide (CAS No. 79-06-1).Q37683873
The carcinogenicity of dietary acrylamide intake: a comparative discussion of epidemiological and experimental animal research.Q37695280
Exposure to acrylamide and human cancer--a review and meta-analysis of epidemiologic studiesQ37829126
New trends in quantification of acrylamide in food products.Q37953723
The acrylamide problem: a plant and agronomic science issue.Q37985793
Development of a physiologically-based toxicokinetic model of acrylamide and glycidamide in rats and humansQ43233566
Reproductive toxicity of acrylamide-treated male ratsQ43244842
Effect of prenatal and perinatal acrylamide on the biochemical and morphological changes in liver of developing albino rat.Q43253715
Effects of chronic oral acrylamide exposure on incremental repeated acquisition (learning) task performance in Fischer 344 ratsQ43257425
Acrylamide formed at physiological temperature as a result of asparagine oxidationQ43273119
Dietary acrylamide intake and the risk of head-neck and thyroid cancers: results from the Netherlands Cohort StudyQ43282890
Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.Q43299139
Acrylamide-induced molecular mutation spectra at HPRT locus in human promyelocytic leukaemia HL-60 and NB4 cell linesQ39992511
Acrylamide intake through diet and human cancer risk.Q40071475
Exploration of different methods to assess dietary acrylamide exposure in pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa).Q40074626
Expression profile of human cells in culture exposed to glycidamide, a reactive metabolite of the heat-induced food carcinogen acrylamideQ40083960
Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cellsQ40095347
Dietary exposure to acrylamide in adolescents from a Canadian urban centerQ40099905
Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion.Q40101218
Approaches to acrylamide physiologically based toxicokinetic modeling for exploring child-adult dosimetry differencesQ40148266
Cytogenetic damage induced by acrylamide and glycidamide in mammalian cells: correlation with specific glycidamide-DNA adductsQ40211450
Acrylamide, an in vivo thyroid carcinogenic agent, induces DNA damage in rat thyroid cell lines and primary culturesQ40252698
Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and alpha-acetoxy-N-nitroso-diethanolamine in human blood and in mammalian V79-cellsQ40295064
Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender.Q40451796
Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk.Q40453284
Mutagenicity and DNA repair of glycidamide-induced adducts in mammalian cells.Q40466447
DNA strand breaking capacity of acrylamide and glycidamide in mammalian cells.Q40466456
Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood.Q40466463
Protein sulfhydryls and their role in the antioxidant function of protein S-thiolationQ40539811
A physiologically based pharmacokinetic model for acrylamide and its metabolite, glycidamide, in the rat.Q40611233
The metabolism and pharmacokinetics of acrylamide: implications for mechanisms of toxicity and human risk estimationQ41262259
Protective effect of allicin against glycidamide-induced toxicity in male and female miceQ41323520
Acrylamide-induced increases in deposition of axonally transported glycoproteins in rat sciatic nerveQ41351525
Acrylamide neuropathy in the rat: effects on energy metabolism in sciatic nerveQ41359824
Editorial: Guidelines on the analysis of tumour rates and death rates in experimental animalsQ41442627
The effects of acrylamide given acutely or in repeated doses on fore- and hindlimb function of ratsQ41655345
Potential Association of Urinary N7-(2-Carbamoyl-2-hydroxyethyl) Guanine with Dietary Acrylamide Intake of Smokers and NonsmokersQ41716081
Toxicological effects of short-term dietary acrylamide exposure in male F344 ratsQ41728775
Effects of nitrogen and sulfur fertilization on free amino acids, sugars, and acrylamide-forming potential in potato.Q41915285
Formation of acrylamide at temperatures lower than 100°C: the case of prunes and a model studyQ42137166
Neuroprotective effect of vitamin e supplementation in wistar rat treated with acrylamideQ42139809
Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohortQ42171410
Maternal-foetal distribution studies in late pregnancy. II. Distribution of [1-14C]acrylamide in tissues of beagle dogs and miniature pigsQ42225376
The mRNA expression and histological integrity in rat forebrain motor and sensory regions are minimally affected by acrylamide exposure through drinking waterQ42458130
Intestinal transport and metabolism of acrylamideQ42507679
Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rateQ42517516
Carcinogenicity of glycidol in F344 rats and B6C3F1 miceQ42553918
Preweaning behaviors, developmental landmarks, and acrylamide and glycidamide levels after pre- and postnatal acrylamide treatment in ratsQ42647467
Urinary concentrations of acrylamide (AA) and N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) and associations with demographic factors in the South Korean populationQ42654308
Dietary levels of acrylamide affect rat cardiomyocyte propertiesQ42705223
Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 ratsQ42719639
Reversible aberration of neurogenesis targeting late-stage progenitor cells in the hippocampal dentate gyrus of rat offspring after maternal exposure to acrylamide.Q42722349
Olive oil hydroxytyrosol reduces toxicity evoked by acrylamide in human Caco-2 cells by preventing oxidative stressQ42730264
Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamideQ42746085
Life stage-related differences in susceptibility to acrylamide-induced neural and testicular toxicityQ42761006
Disruptive neuronal development by acrylamide in the hippocampal dentate hilus after developmental exposure in ratsQ42789286
Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats.Q42876624
The effects of acrylamide on sperm parameters and membrane integrity of epididymal spermatozoa in miceQ42939235
Dietary acrylamide exposure and hemoglobin adducts--National Health and Nutrition Examination Survey (2003-04).Q42942492
Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studiesQ42959406
Development of a certified reference material for the determination of acrylamide in potato chipsQ42972104
Evaluation of the genotoxicity of 10 selected dietary/environmental compounds with the in vitro micronucleus cytokinesis-block assay in an interlaboratory comparisonQ42988336
Estimation of the dietary acrylamide exposure of the Polish populationQ43063017
Validation of a database on acrylamide for use in epidemiological studiesQ43127056
The genotoxicity of acrylamide and glycidamide in big blue rats.Q43143777
Enhanced fat consumption potentiates acrylamide-induced oxidative stress in epididymis and epididymal sperm and effect spermatogenesis in miceQ43160863
In vitro investigations of glycidamide-induced DNA lesions in mouse male germ cells and in mouse and human lymphocytesQ43212437
Simultaneous quantification of haemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile, acrylamide and glycidamide in human blood by isotope-dilution GC/NCI-MS/MS.Q43218344
Dietary acrylamide intake and estrogen and progesterone receptor-defined postmenopausal breast cancer risk.Q43233331
Estimation of safe dietary intake levels of acrylamide for humansQ43233565
P433issue6
P304page(s)4104
P577publication date2015-06-01
P1433published inEFSA JournalQ56298557
P1476titleScientific Opinion on acrylamide in food
P478volume13

Reverse relations

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